Sex steroids during bone growth: A comparative study between mouse models for hypogonadal and senile osteoporosis

Osteoporosis International

Volumn 20, Issue 10, 2009, Pages 1749-1757

  Ophoff, J ^a   Venken, K ^a   Callewaert, F ^a   Boonen, S ^a   Bouillon, R ^a   Vanderschueren, D ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Longitudinal follow up; Orchidectomy; Puberty; SAMP6; Sex steroids

Indexed keywords

ANDROSTANOLONE; ESTRADIOL; SEX HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; BONE FRAGILITY; BONE GROWTH; BONE MASS; BONE MINERAL; BONE TURNOVER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; HYPOGONADAL OSTEOPOROSIS; HYPOGONADISM; MALE; MOUSE; NONHUMAN; ORCHIECTOMY; OSSIFICATION; OSTEOPOROSIS; PERIOSTEUM; PRIORITY JOURNAL; SENILE OSTEOPOROSIS; TRABECULAR BONE;

ABSORPTIOMETRY, PHOTON; AGING; AMINO ACIDS; ANIMALS; BONE DEVELOPMENT; DIHYDROTESTOSTERONE; DISEASE MODELS, ANIMAL; ESTRADIOL; GONADAL STEROID HORMONES; HORMONE REPLACEMENT THERAPY; HYPOGONADISM; MALE; MICE; ORCHIECTOMY; OSTEOCALCIN; OSTEOPOROSIS; PHENOTYPE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 69949171997     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-009-0851-z     Document Type: Article

References (38)

1. LJ Melton 3rd EA Chrischilles C Cooper, et al. 1992 Perspective. How many women have osteoporosis? J Bone Miner Res 7 1005 1010
2. JR Center TV Nguyen D Schneider, et al. 1999 Mortality after all major types of osteoporotic fracture in men and women: an observational study Lancet 353 878 882
3. L Forsen AJ Sogaard HE Meyer, et al. 1999 Survival after hip fracture: short- and long-term excess mortality according to age and gender Osteoporos Int 10 73 78
4. S Khosla S Amin E Orwoll 2008 Osteoporosis in men Endocr Rev 29 441 464
5. I Van Pottelbergh S Goemaere H Zmierczak, et al. 2003 Deficient acquisition of bone during maturation underlies idiopathic osteoporosis in men: evidence from a three-generation family study J Bone Miner Res 18 303 311
6. T Takeda M Hosokawa S Takeshita, et al. 1981 A new murine model of accelerated senescence Mech Ageing Dev 17 183 194
7. T Takeda M Hosokawa K Higuchi 1997 Senescence-accelerated mouse (SAM): a novel murine model of senescence Exp Gerontol 32 105 109
8. MJ Silva MD Brodt SL Ettner 2002 Long bones from the senescence accelerated mouse SAMP6 have increased size but reduced whole-bone strength and resistance to fracture J Bone Miner Res 17 1597 1603
9. MJ Silva MD Brodt Z Fan, et al. 2004 Nanoindentation and whole-bone bending estimates of material properties in bones from the senescence accelerated mouse SAMP6 J Biomech 37 1639 1646
10. MJ Silva MD Brodt B Wopenka, et al. 2006 Decreased collagen organization and content are associated with reduced strength of demineralized and intact bone in the SAMP6 mouse J Bone Miner Res 21 78 88
11. MJ Silva MD Brodt M Ko, et al. 2005 Impaired marrow osteogenesis is associated with reduced endocortical bone formation but does not impair periosteal bone formation in long bones of SAMP6 mice J Bone Miner Res 20 419 427
12. RS Weinstein RL Jilka AM Parfitt, et al. 1997 The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage Endocrinology 138 4013 4021
13. RL Jilka RS Weinstein K Takahashi, et al. 1996 Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence J Clin Invest 97 1732 1740
14. ES Orwoll RF Klein 1995 Osteoporosis in men Endocr Rev 16 87 116
15. K Venken K De Gendt S Boonen, et al. 2006 Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model J Bone Miner Res 21 576 585
16. BT Kim L Mosekilde Y Duan, et al. 2003 The structural and hormonal basis of sex differences in peak appendicular bone strength in rats J Bone Miner Res 18 150 155
17. T Notomi Y Okazaki N Okimoto, et al. 2002 Effects of tower climbing exercise on bone mass, strength, and turnover in orchidectomized growing rats J Appl Physiol 93 1152 1158
18. D Vanderschueren L Vandenput S Boonen, et al. 2004 Androgens and bone Endocr Rev 25 389 425
19. D Vanderschueren L Vandenput S Boonen, et al. 2000 An aged rat model of partial androgen deficiency: prevention of both loss of bone and lean body mass by low-dose androgen replacement Endocrinology 141 1642 1647
20. L Vandenput JV Swinnen S Boonen, et al. 2004 Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model J Bone Miner Res 19 1462 1470
21. L Vandenput AG Ederveen RG Erben, et al. 2001 Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-alpha knockout mice Biochem Biophys Res Commun 285 70 76
22. AM Parfitt MK Drezner FH Glorieux, et al. 1987 Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee J Bone Miner Res 2 595 610
23. J Verhaeghe E Van Herck R Van Bree, et al. 1989 Osteocalcin during the reproductive cycle in normal and diabetic rats J Endocrinol 120 143 151
24. D Vanderschueren I Jans E van Herck, et al. 1994 Time-related increase of biochemical markers of bone turnover in androgen-deficient male rats Bone Miner 26 123 131
25. BL Riggs S Khosla LJ Melton 3rd 1999 The assembly of the adult skeleton during growth and maturation: implications for senile osteoporosis J Clin Invest 104 671 672
26. MJ Silva MD Brodt BA Uthgenannt 2004 Morphological and mechanical properties of caudal vertebrae in the SAMP6 mouse model of senile osteoporosis Bone 35 425 431
27. H Chen S Shoumura S Emura 2004 Ultrastructural changes in bones of the senescence-accelerated mouse (SAMP6): a murine model for senile osteoporosis Histol Histopathol 19 677 685 (Pubitemid 38855047)
28. S Filardi RM Zebaze Y Duan, et al. 2004 Femoral neck fragility in women has its structural and biomechanical basis established by periosteal modeling during growth and endocortical remodeling during aging Osteoporos Int 15 103 107
29. A Tabensky Y Duan J Edmonds, et al. 2001 The contribution of reduced peak accrual of bone and age-related bone loss to osteoporosis at the spine and hip: insights from the daughters of women with vertebral or hip fractures J Bone Miner Res 16 1101 1107
30. HZ Ke DT Crawford H Qi, et al. 2001 Long-term effects of aging and orchidectomy on bone and body composition in rapidly growing male rats J Musculoskelet Neuronal Interact 1 215 224
31. NS Reim B Breig K Stahr, et al. 2008 Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling J Bone Miner Res 23 694 704
32. L Pederson M Kremer J Judd, et al. 1999 Androgens regulate bone resorption activity of isolated osteoclasts in vitro Proc Natl Acad Sci U S A 96 505 510
33. BZ Leder KM LeBlanc DA Schoenfeld, et al. 2003 Differential effects of androgens and estrogens on bone turnover in normal men J Clin Endocrinol Metab 88 204 210
34. A Samuels MJ Perry AE Goodship, et al. 2000 Is high-dose estrogen-induced osteogenesis in the mouse mediated by an estrogen receptor? Bone 27 41 46
35. SD Bain MC Bailey DL Celino, et al. 1993 High-dose estrogen inhibits bone resorption and stimulates bone formation in the ovariectomized mouse J Bone Miner Res 8 435 442
36. L Katznelson JS Finkelstein DA Schoenfeld, et al. 1996 Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism J Clin Endocrinol Metab 81 4358 4365
37. PA Heine JA Taylor GA Iwamoto, et al. 2000 Increased adipose tissue in male and female estrogen receptor-alpha knockout mice Proc Natl Acad Sci U S A 97 12729 12734
38. ME Jones AW Thorburn KL Britt, et al. 2001 Aromatase-deficient (ArKO) mice accumulate excess adipose tissue J Steroid Biochem Mol Biol 79 3 9