The use of thyroid function tests in the diagnosis of hypopituitarism: Definition and evaluation of the TSH Index

Clinical Endocrinology

Volumn 71, Issue 4, 2009, Pages 529-534

  Jostel, Andreas ^a   Ryder, W David J ^a   Shalet, Stephen M ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; HYDROCORTISONE; THYROTROPIN; THYROXINE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENDOCRINE FUNCTION TEST; FEMALE; FREE THYROXINE INDEX; GROWTH HORMONE BLOOD LEVEL; HORMONE ACTION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOPHYSIS FUNCTION; HYPOPITUITARISM; MAJOR CLINICAL STUDY; MALE; NEGATIVE FEEDBACK; PRIORITY JOURNAL; THYROID FUNCTION TEST; THYROTROPIN BLOOD LEVEL; THYROTROPIN RELEASE;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; HYPOPITUITARISM; MALE; MIDDLE AGED; REFERENCE VALUES; THYROID FUNCTION TESTS; THYROTROPHS; THYROTROPIN; THYROXINE;

EID: 69949164471     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2009.03534.x     Document Type: Article

References (17)

1. Littley, M.D., Shalet, S.M., Beardwell, C.G. et al 1989) Hypopituitarism following external radiotherapy for pituitary tumours in adults. Quarterly Journal of Medicine, 70, 145 160.
2. Shimon, I., Cohen, O., Lubetsky, A. et al 2002) Thyrotropin suppression by thyroid hormone replacement is correlated with thyroxine level normalization in central hypothyroidism. Thyroid, 12, 823 827.
3. Spencer, C.A., LoPresti, J.S., Patel, A. et al 1990) Applications of a new chemiluminometric thyrotropin assay to subnormal measurement. Journal of Clinical Endocrinology and Metabolism, 70, 453 460.
4. Ercan-Fang, S., Schwartz, H.L., Mariash, C.N. et al 2000) Quantitative assessment of pituitary resistance to thyroid hormone from plots of the logarithm of thyrotropin versus serum free thyroxine index. Journal of Clinical Endocrinology and Metabolism, 85, 2299 2303.
5. Andersen, S., Pedersen, K.M., Bruun, N.H. et al 2002) Narrow individual variations in serum T(4) and T(3) in normal subjects: a clue to the understanding of subclinical thyroid disease. Journal of Clinical Endocrinology and Metabolism, 87, 1068 1072.
6. R Development Core Team (2007) R: a Language and Environment for Statistical Computing : Vienna, Austria. http://www.R-project.org.
7. Pinheiro, J.C. Bates, D.M. (2000) Mixed-Effects Models in S and S-PLUS. Springer-Verlag, New York.
8. Collett, D. (1991) Modelling Binary Data. Chapman & Hall, London.
9. Hastie, T.J. Tibshirani, R.J. (1990) Generalised Additive Models. Chapman & Hall, London.
10. Meier, C.A., Maisey, M.N., Lowry, A. et al 1993) Interindividual differences in the pituitary-thyroid axis influence the interpretation of thyroid function tests. Clinical Endocrinology, 39, 101 107.
11. Leow, M.K. (2007) A mathematical model of pituitary-thyroid interaction to provide an insight into the nature of the thyrotropin-thyroid hormone relationship. Journal of Theoretical Biology, 248, 275 287.
12. Koltowska-Haggstrom, M., Mattsson, A.F., Monson, J.P. et al 2006) Does long-term GH replacement therapy in hypopituitary adults with GH deficiency normalise quality of life? European Journal of Endocrinology, 155, 109 119.
13. Price, D.A., Wilton, P., Jonsson, P. et al 1996) Efficacy and safety of growth hormone treatment in children with prior craniopharyngioma: an analysis of the Pharmacia and Upjohn International Growth Database (KIGS) from 1988 to 1998. Hormone Research, 49, 91 97.
14. Persani, L., Ferretti, E., Borgato, S. et al 2000) Circulating thyrotropin bioactivity in sporadic central hypothyroidism. Journal of Clinical Endocrinology and Metabolism, 85, 3631 3635.
15. Jostel, A., Blower, M.G. Shalet, S.M. (2006) Highly preserved correlation between free thyroxine and thyrotropin concentrations in patients with established panhypopituitarism [P2-762]. In: ENDO 2006 Program and Abstracts Book. Endocrine Society Press, Chevy Chase, MD, USA.
16. Jostel, A., Ryder, W.D.J. Shalet, S.M. (2007) The concept of 'thyroid intercepts' and its application in the diagnosis of central hypothyroidism and pituitary dysfunction [P2-561]. In: ENDO 2007 Program and Abstracts Book. Endocrine Society Press, Chevy Chase, MD, USA.
17. Jostel, A., Ryder, W.D.J., Shalet, S.M. et al 2008) The TSH Index: definition and clinical evaluation [P2-751]. In: ENDO 2008 Program and Abstracts Book. Endocrine Society Press, Chevy Chase, MD, USA.