Design and synthesis of carbon-11-labeled dual aromatase-steroid sulfatase inhibitors as new potential PET agents for imaging of aromatase and steroid sulfatase expression in breast cancer

Steroids

Volumn 74, Issue 12, 2009, Pages 896-905

  Wang, Min ^a   Mickens, Jarrett ^a   Gao, Mingzhang ^a   Miller, Kathy D ^a   Sledge, George W ^a   Hutchins, Gary D ^a   Zheng, Qi Huang ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aromatase; Cancer imaging; Positron emission tomography; Radiotracers; Steroid sulfatase; Sulfamate derivatives

Indexed keywords

4 [[(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL] 2 METHOXYPHENYL SULFAMATE CARBON 11; 5 [[(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL] 2 METHOXYPHENYL SULFAMATE CARBON 11; AROMATASE INHIBITOR; CARBON 11; STERYL SULFATASE; TRACER; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION;

AROMATASE; AROMATASE INHIBITORS; BREAST NEOPLASMS; CARBON RADIOISOTOPES; DRUG DESIGN; GENE EXPRESSION REGULATION, NEOPLASTIC; ISOTOPE LABELING; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; STERYL-SULFATASE; SULFONIC ACIDS;

EID: 69949163646     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2009.06.006     Document Type: Article

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