High-level rifampin resistance correlates with multiple mutations in the rpoB gene of pulmonary tuberculosis isolates from the Afghanistan border of Iran

Journal of Clinical Microbiology

Volumn 47, Issue 9, 2009, Pages 2744-2750

  Bahrmand, Ahmad Reza ^a,b   Titov, Leonid P ^c   Tasbiti, Alireza Hadizadeh ^b   Yari, Shamsi ^b   Graviss, Edward A ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

^c Research Institute for Epidemiology & Microbiology RIEM   (Belarus)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; ETHAMBUTOL; ETHIONAMIDE; ISONIAZID; KANAMYCIN; RIFAMPICIN; STREPTOMYCIN; TUBERCULOSTATIC AGENT;

AFGHANISTAN; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM CULTURE; BACTERIUM ISOLATE; CLINICAL ARTICLE; CODON; DNA EXTRACTION; DNA SEQUENCE; ENDEMIC DISEASE; GENE AMPLIFICATION; GENE MUTATION; HUMAN; IRAN; LUNG TUBERCULOSIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RPOB GENE; SPUTUM ANALYSIS;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; HUMANS; IRAN; MICROBIAL SENSITIVITY TESTS; MUTATION, MISSENSE; MYCOBACTERIUM TUBERCULOSIS; RIFAMPIN; SEQUENCE ANALYSIS, DNA; SPUTUM; TUBERCULOSIS, PULMONARY;

MYCOBACTERIUM TUBERCULOSIS;

EID: 69949110844     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.r00548-09     Document Type: Article

References (37)

1. Bakonyte, D., A. Baranauskaite, J. Cicenaite, A. Sosnovskaja, and P. Stakenas. 2005. Mutations in the rpoB gene of rifampin-resistant Mycobacterium tuberculosis clinical isolates from Lithuania. Int. J. Tuberc. Lung Dis. 9:936-938.
2. Barfai, Z., A. Somoskovi, C. Kodmon, N. Szabo, E. Puskas, L. Kosztolanyi, E. Frago, J. Mester, L. M. Parsons, and M. Salfinger. 2001. Molecular characterization of rifampin-resistant isolates of Mycobacterium tuberculosis from Hungary by DNA sequencing and the line probe assay. J. Clin. Microbiol. 39:3736-3739.
3. Billington, O. J., T. D. McHugh, and S. H. Gillespie. 1999. Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 43:1866-1869.
4. Bobadilla-del-Valle, M., A. Ponce-de-Leon, C. Arenas-Huertero, G. Vargas- Alarcon, M. Kato-Maeda, P. M. Small, P. Couary, G. M. Ruiz-Palacios, and J. Sifuentes-Osornio. 2001. rpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis identified by polymerase chain reaction single-stranded conformational polymorphism. Emerg. Infect. Dis. 7:1010-1013.
5. Fan, X. Y., Z. Y. Hu, F. H. Xu, Z. Q. Yan, S. Q. Guo, and Z. M. Li. 2003. Rapid detection of rpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis isolates in Shanghai by using the amplification refractory mutation system. J. Clin. Microbiol. 41:993-997.
6. Hirano, K., C. Abe, and M. Takahashi. 1999. Mutations in the rpoB gene of rifampin-resistant Mycobacterium tuberculosis strains isolated mostly in Asian countries and their rapid detection by line probe assay. J. Clin. Microbiol. 37:2663-2666.
7. Huang, H., Q. W. Jin, Y. Ma, X. Chen, and Y. Zhuangz. 2002. Characterization of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis isolated in China. Tuberculosis 82:79-83.
8. Isfahani, B. N., A. Tavakoli, M. Salehi, and M. Tazhibi. 2006. Detection of rifampin resistance patterns in Mycobacterium tuberculosis strains isolated in Iran by polymerase chain reaction-single-strand conformation polymorphism and direct sequencing methods. Mem. Inst. Oswaldo Cruz 101:597-602.
9. Kapur, V., L.-L. Li, S. Iordanescu, M. R. Hamrick, A. Wagner, B. N. Kreiswirth, and J. M. Musser. 1994. Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase β subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York and Texas. J. Clin. Microbiol. 32:1095-1098.
10. Kent, P. T., and G. P. Kubica. 1985. Public health mycobacteriology, a guide for the level III laboratory, p. 21-30. Publication no. (CDC) 86-216546. Centers for Disease Control, U.S. Department of Health and Human Services, Atlanta, GA.
11. Kim, B. J., S. K. Hong, K. H. Lee, Y. J. Yun, E. C. Kim, Y. G. Park, G. H. Bai, and Y. H. Kook. 2004. Differential identification of Mycobacterium tuberculosis complex and nontuberculous mycobacteria by duplex PCR assay using the RNA polymerase gene (rpoB). J. Clin. Microbiol. 42:1308-1312.
12. Lin, S. Y. G., W. Probert, M. Lo, and E. Desmond. 2004. Rapid detection of isoniazid and rifampin resistance mutations in Mycobacterium tuberculosis complex from cultures or smear-positive sputa by use of molecular beacons. J. Clin. Microbiol. 42:4204-4208.
13. Mani, C., N. Selvakumar, S. Narayanan, and P. R. Narayanan. 2001. Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis clinical isolates from India. J. Clin. Microbiol. 39:2987-2990.
14. Marin, M., D. G. de Viedma, M. J. Ruiz-Serrano, and E. Bouza. 2004. Rapid direct detection of multiple rifampin and isoniazid resistance mutations in Mycobacterium tuberculosis in respiratory samples by real-time PCR. Antimicrob. Agents Chemother. 48:4293-4300.
15. Matsiota-Bernard, P., G. Vrioni, and E. Marinis. 1998. Characterization of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Greece. J. Clin. Microbiol. 36:20-23.
16. McCammon, M. T., J. S. Gillette, D. P. Thomas, S. V. Ramaswamy, E. A. Graviss, B. N. Kreiswirth, J. Vijg, and T. N. Quitugua. 2005. Detection of rpoB mutation associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis. Antimicrob. Agents Chemother. 49:2200-2209.
17. Mikhailovich, V., S. Lapa, D. Gryadunov, A. Sobolev, B. Strizhkov, N. Chernyh, O. Skotnikova, O. Irtuganova, A. Moroz, V. Litvinov, M. Vladimirovskii, M. Perelman, L. Chernousova, V. Erokhin, A. Zasedatelev, and A. Mirzabekov. 2001. Identification of rifampin-resistant Mycobacterium tuberculosis strains by hybridization, PCR, and ligase detection reaction on oligonucleotide microchips. J. Clin. Microbiol. 39:2531-2540.
18. Mohammad, H. N., A. Sadeghian, M. Naderinasab, and M. Ziaee. 2006. Prevalence of primary drug resistant Mycobacterium tuberculosis in Mashhad, Iran. Indian J. Med. Res. 124:77-80.
19. Mokrousov, I. 2004. Multiple rpoB mutants of Mycobacterium tuberculosis and second-order selection. Emerg. Infect. Dis. 10:1337-1338.
20. Mokrousov, I., T. Otten, B. Vyshnevskiy, and O. Narvskaya. 2003. Allelespecific rpoB PCR assays for detection of rifampin-resistant Mycobacterium tuberculosis in sputum smears. Antimicrob. Agents Chemother. 47:2231-2235.
21. Musser, J. M. 1995. Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin. Microbiol. Rev. 8:496-514.
22. Ohno, H., H. Koga, S. Kohno, T. Tashiro, and K. Hara. 1996. Relationship between rifampin MICs for and rpoB mutations of Mycobacterium tuberculosis strains isolated in Japan. Antimicrob. Agents Chemother. 40:1053-1056.
23. Pozzi, G., M. Meloni, E. Iona, G. Orro, O. F. Thorensen, M. L. Ricci, M. R. Oggioni, L. Fattorini, and G. Orefici. 1999. rpoB mutations in multidrug resistant strains of Mycobacterium tuberculosis isolated in Italy. J. Clin. Microbiol. 37:1197-1199.
24. Qian, L., C. Abe, T. P. Lin, M. Yu, S. Cho, S. Wang, and J. T. Douglas. 2002. rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from east Asian countries. J. Clin. Microbiol. 40:1091-1093.
25. Ruiz, M., M. J. Torres, A. C. Llanos, A. Arroyo, and J. C. Palomares. 2004. Direct detection of rifampin- and isoniazid-resistant Mycobacterium tuberculosis in auramine-rhodamine-positive sputum specimens by real-time PCR. J. Clin. Microbiol. 42:1585-1589.
26. Sajduda, A., A. Brzostek, M. Popławska, E. Augustynowicz- Kopeć, Z. Zwolska, S. Niemann, J. Dziadek, and D. Hillemann. 2004. Molecular characterization of rifampin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Poland. J. Clin. Microbiol. 42:2425-2431.
27. Spindola de Miranda, S., A. L. Kritski, I. Filliol, C. Mabilat, and D. E. Panteix. 2001. Mutation in the rpoB gene of rifampin-resistant Mycobacterium tuberculosis strains isolated in Brazil and France. Mem. Inst. Oswaldo Cruz 96:247-250.
28. Telenti, A., P. Imboden, F. Marchesi, D. Lowrie, S. Cole, M. J. Colston, L. Matter, K. Schopfer, and T. Bodmer. 1993. Detection of rifampin-resistance mutations in Mycobacterium tuberculosis. Lancet 341:647-650. (Pubitemid 23083244)
29. Telenti, A., N. Honore, C. Brenasconi, J. March, H. E. Takiff, and S. T. Cole. 1997. Genotyping assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level. J. Clin. Microbiol. 35:719-723.
30. Titov, L. P., S. B. Zaker, V. Slizen, L. K. Surkova, M. Taghikhani, and A. R. Bahrmand. 2006. Molecular characterization of rpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis isolates from tuberculosis patients in Belarus. Biotechnol. J. 24:1447-1452.
31. Valim, A. R., M. L. Rosetti, M. O. Ribeiro, and A. Zaha. 2000. Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from Brazil. J. Clin. Microbiol. 38:3119-3122.
32. van der Zanden, A. G. M., E. M. Te Koppele-Vije, N. Vijaya Bhanu, D. van Soolingen, and L. M. Schouls. 2003. Use of DNA extracts from Ziehl-Neelsen-stained slides for molecular detection of rifampin resistance and spoligotyping of Mycobacterium tuberculosis. J. Clin. Microbiol. 41:1101-1108.
33. Williams, D. L., I. Spring, I. Collins, L. P. Miller, L. B. Heifets, P. R. J. Gangadharam, and T. P. Gillis. 1998. Contribution of rpoB mutations to development of rifampin cross-resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 42:1853-1857.
34. Williams, D. L., C. Wanguespack, K. Eisanach, J. T. Crawford, F. Porteals, M. Salfinger, C. M. Nolan, C. Abe, V. Sticht-Groh, and T. P. Gillis. 1994. Characterization of rifampin resistance in pathogenic Mycobacteria. Antimicrob. Agents Chemother. 38:2380-2386.
35. World Health Organization. 2002. An expanded DOTS framework for effective tuberculosis control. Document WHO/CDS/TB.297. World Health Organization, Geneva, Switzerland.
36. Yun, Y. J., K. H. Lee, L. Haihua, Y. J. Ryu, B. J. Kim, Y. H. Lee, G. H. Baek, H. J. Kim, M. S. Chung, M. C. Lee, S. H. Lee, I. H. Choi, T. J. Cho, B. S. Chang, and Y. H. Kook. 2005. Detection and identification of Mycobacterium tuberculosis in joint biopsy specimens by rpoB PCR cloning and sequencing. J. Clin. Microbiol. 43:174-178.
37. Zaker, S. B., L. P. Titov, A. R. Bahrmand, and M. Tagikhani. 2006. Mutability of stability genes to isoniazid and rifampin in M. tuberculosis of patients. Dokl. Natl. Acad. Sci. Belarus 50:84-89.