Endothelial Progenitor Cells as a Therapeutic Option in Peripheral Arterial Disease

European Journal of Vascular and Endovascular Surgery

Volumn 38, Issue 4, 2009, Pages 475-481

  Devanesan, A J ^a   Laughlan, K A ^a   Girn, H R S ^a   Homer Vanniasinkam, S ^a  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

Ischaemia; Peripheral arterial disease; Progenitor cells; Stem cell therapy

Indexed keywords

ARTERY DISEASE; BONE MARROW CELL; CARDIOVASCULAR RISK; CELL FUNCTION; CELL SURVIVAL; CEREBROVASCULAR DISEASE; CLINICAL TRIAL; COCHRANE LIBRARY; ENDOTHELIUM CELL; HEART MUSCLE ISCHEMIA; HEMATOPOIETIC STEM CELL; HUMAN; LIMB ISCHEMIA; MEDICAL ETHICS; MEDLINE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEM CELL TRANSPLANTATION; TREATMENT RESPONSE;

ANIMALS; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CEREBROVASCULAR DISORDERS; ENDOTHELIAL CELLS; EXTREMITIES; HUMANS; ISCHEMIA; MYOCARDIAL ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; PERIPHERAL VASCULAR DISEASES; RISK FACTORS; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME;

EID: 69949103628     PISSN: 10785884     EISSN: 15322165     Source Type: Journal    
DOI: 10.1016/j.ejvs.2009.05.019     Document Type: Review

References (49)

1. Asahara T., Murohara T., Sullivan A., Silver M., van der Zee R., Li T., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275 (1997) 964-967
2. Ingram D.A., Mead L.E., Tanaka H., Meade V., Fenoglio A., Mortell K., et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 104 (2004) 2752-2760
3. Urayama K., Guilini C., Turkeri G., Takir S., Kurose H., Messaddeq N., et al. Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation. Arterioscler Thromb Vasc Biol 28 5 (2008) 841-849
4. Tepper O.M., Galiano R.D., Capla J.M., Kalka C., Gagne P.J., Jacobowitz G.R., et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion and incorporation into vascular structures. Circulation 106 (2002) 2781-2786
5. Chen J.Z., Zhang F.R., Tao Q.M., Wang X.X., and Zhu J.H. Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia. Clin Sci (Lond) 107 (2004) 273-280
6. Kondo T., Hayashi M., Takeshita K., Numaguchi Y., Kobayashi K., Iino S., et al. Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers. Arterioscler Thromb Vasc Biol 24 (2004) 1442-1447
7. Scheubel R.J., Zorn H., Silber R.E., Kuss O., Morawietz H., Holtz J., et al. Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J Am Coll Cardiol 42 (2003) 2073-2080
8. Vasa M., Fichtlscherer S., Aicher A., Adler K., Urbich C., Martin H., et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 89 (2001) 1-7
9. Zuk P.A., Zhu M., Mizuno H., Huang J., Futrell J.W., Katz A.J., et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7 (2001) 211-228
10. Aicher A., Zeiher A.M., and Dimmeler S. Mobilizing endothelial progenitor cells. Hypertension 45 (2005) 321-325
11. Rehman J., Li J., Orschell C.M., and March K.L. Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 107 (2003) 1164-1169
12. Porat Y., Porozov S., Belkin D., Shimoni D., Fisher Y., Belleli A., et al. Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages. Br J Haematol 135 5 (2006) 703-714
13. Couffinhal T., Silver M., Kearney M., Sullivan A., Witzenbichler B., Magner M., et al. Impaired collateral vessel development associated with reduced expression of vascular endothelial growth factor in ApoE-/- mice. Circulation 99 24 (1999) 3188-3198
14. Auerbach R., Lewis R., Shinners B., Kubai L., and Akhtar N. Angiogenesis assays: a critical overview. Clin Chem 49 1 (2003) 32-40
15. Smythe J., Fox A., Fisher N., Frith E., Harris A.L., and Watt S.M. Measuring angiogenic cytokines, circulating endothelial cells, and endothelial progenitor cells in peripheral blood and cord blood: VEGF and CXCL12 correlate with the number of circulating endothelial progenitor cells in peripheral blood. Tissue Eng Part C Methods 14 1 (2008) 59-67
16. Shao H., Tan Y., Eton D., Yang Z., Uberti M.G., Li S., et al. Statin and stromal-derived factor-1 additively promote angiogenesis by enhancement of progenitor cells incorporation into new vessels. Stem Cells 26 5 (2008) 1376-1384
17. Humpert P.M., Djuric Z., Zeuge U., Oikonomou D., Seregin Y., Laine K., et al. Insulin stimulates the clonogenic potential of angiogenic endothelial progenitor cells by IGF-1 receptor-dependent signaling. Mol Med 14 5-6 (2008) 301-308
18. Ishizawa K., Kubo H., Yamada M., Kobayashi S., Suzuki T., Mizuno S., et al. Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells. Biochem Biophys Res Commun 324 1 (2004) 276-280
19. Napoli C., Balestrieri A., and Ignarro L.J. Therapeutic approaches in vascular repair induced by adult bone marrow cells and circulating progenitor endothelial cells. Curr Pharm Des 13 31 (2007) 3245-3251
20. Murasawa S., Llevadot J., Silver M., Isner J.M., Losordo D.W., and Asahara T. Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells. Circulation 106 (2002) 1133-1139
21. Ishida A., Ohya Y., Sakuda H., Ohshiro K., Higashiuesato Y., Nakaema M., et al. Autologous peripheral blood mononuclear cell implantation for patients with peripheral arterial disease improves limb ischemia. Circ J 69 10 (2005) 1260-1265
22. Ballard V.L.T., and Edelberg J.M. Stem cells and the regeneration of the aging cardiovascular system. Circ Res 100 (2007) 1116-1127
23. Werner N., and Nickenig G. Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy?. Arterioscler Thromb Vasc Biol 26 2 (2006) 257-266
24. Loomans C.J.M., de Koning E.J.P., Staal F.J.T., Rookmaaker M.B., Verseyden C., de Boer H.C., et al. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 53 1 (2004) 195-199
25. Imanshi T., Hano T., Matsuo Y., and Nishio I. Oxidized low density lipoprotein inhibits vascular endothelial growth factor induced endothelial progenitor cell differentiation. Clin Exp Pharmacol Physiol 30 (2004) 665-670
26. Vasa M., Fichtlscherer S., Klaudia A., Aicher A., Martin H., Zeiher A.M., et al. Increase in circulating EPC by statin therapy in patients with stable coronary artery disease. Circulation 103 (2001) 2885-2890
27. Laufs U., Urhausen A., Werner N., Scharhag J., Heitz A., Kissner G., et al. Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects. Eur J Cardiovasc Prev Rehabil 12 (2005) 407-414
28. Hill J.M., Zalos G., Halcox J.P., Schenke W.H., Waclawiw M.A., Quyyumi A.A., et al. Circulating endothelial progenitor cells, vascular function and cardiovascular risk. New Eng J Med 348 7 (2003) 593-600
29. Assmus B., Schächinger V., Teupe C., Britten M., Lehmann R., Döbert N., et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 106 (2002) 1913-1918
30. Assmus B., Leistner D., Fischer-Rasokat U., Honold J., Schächinger V., Dimmeler S., et al. Abstract 1894: 5 years follow-up indicate safety and sustained improvement of cardiac function in the TOPCARE-AMI trial. Circulation 118 (2008) S400-S401
31. Wollert K.C., Meyer G., Lotz J., Lichtenberg S.R., Lippolt P., Breidenbach C., et al. Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST randomized controlled clinical trial. Lancet 364 (2004) 141-148
32. Schächinger V., Tonn T., Dimmeler S., and Zeiher A.M. Bone marrow derived progenitor cell therapy in need of proof of concept: design of the REPAIR-AMI trial. Nat Clin Pract Cardiovasc Med 3 Suppl. 1 (2006) S23-S28
33. Fuchs S., Kornowski R., Weisz G., Satler L., Smits P., Okubagzi P., et al. Safety and feasibility of transendocardial autologous bone marrow transplantation in patients with advanced heart disease. Am J Cardiol 97 (2006) 823-829
34. Perin E.C., Dohmann H.F.R., Borojevic R., Silva S.A., Sousa A.L.S., Silva G.V., et al. Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation 110 (2004) 11213-11218
35. Heeschen C., Lehmann R., Honold J., Assmus B., Aicher A., Walter D.H., et al. Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation 109 (2004) 1615-1622
36. Assmus B., Fischer-Rasokat U., Honold J., Seeger F.H., Fichtlscherer S., Tonn T., et al. Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure. Results of the TOPCARE-CHD registry. Circ Res 100 (2007) 1234-1241
37. Rafii S., and Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularisation and regeneration. Nat Med 9 6 (2003) 702-712
38. Tateishi-Yuyama E., Matsubara H., Murohara T., Ikeda U., Shintani S., Masaki H., et al. Therapeutic angiogenesis for patients with limb ischemia by autologous transplantation of bone marrow cells: a pilot study and randomized controlled trial. Lancet 360 (2002) 427-435
39. Matoba S., Tatsumi T., Murohara T., Imaizumi T., Katsuda Y., Ito M., et al. Long term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (therapeutic angiogenesis by cell transplantation TACT trial) in patients with chronic limb ischaemia. Am Heart J 156 5 (2008) 1010-1018
40. Higashi Y., Kimura M., Hara K., Noma K., Jitsuiki D., Nakagawa K., et al. Autologous bone marrow mononuclear cell implantation improves endothelial dependant vasodilatation in patients with limb ischemia. Circulation 109 (2004) 1215-1218
41. Saigawa T., Kato K., Ozawa T., Toba K., Makiyama Y., Minagawa S., et al. Clinical application of bone marrow implantation in patients with atherosclerosis obliterans, and the association between efficacy and the number of implanted bone marrow cells. Circ J 68 (2004) 1189-1193
42. Lenk K., Adams V., Lurz P., Erbs S., Linke A., Gielen S., et al. Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemia. Eur Heart J 26 18 (2005) 1903-1909
43. Kawamura A., Horie T., Tsuda I., Abe Y., Tamada M., Egawa H., et al. Clinical study of therapeutic angiogenesis by autologous peripheral blood stem cell (PBSC) transplantation in 92 patients with critically ischemic limbs. J Artif Organs 9 4 (2006) 226-233
44. Miyamoto K., Nishigami K., Nagaya N., Akutsu K., Chiku M., Kamei M., et al. Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans. Circulation 114 24 (2006) 2679-2684
45. Flugelman M.Y., Virmani R., Correa R., Yu Z.X., Farb A., Leon M.B., et al. Smooth muscle cell abundance and fibroblast growth factors in coronary lesions of patients with nonfatal unstable angina. A clue to the mechanism of transformation from the stable to the unstable clinical state. Circulation 88 (1993) 2493-2500
46. 2 vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat. Free Radic Biol Med 28 (2000) 91-101
47. Zhang Z.G., Zhang L., Jiang Q., and Chopp M. Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ Res 90 (2002) 284-288
48. Yip H.K., Chang L.T., Chang W.N., Lu C.H., Liou C.W., Lan M.Y., et al. Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke. Stroke 39 1 (2008) 69-74
49. Xiao J., Nan Z., Motooka Y., and Low W.C. Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury. Stem Cells Dev 14 6 (2005) 722-733