A new endpoint definition improved clinical relevance and statistical power in a vaccine trial

Journal of Clinical Epidemiology

Volumn 62, Issue 10, 2009, Pages 1054-1061

  Pédrono, Gaëlle ^a   Thiébaut, Rodolphe ^a,b   Alioum, Ahmadou ^a,b   Lesprit, Philippe ^c   Fritzell, Bernard ^d   Lévy, Yves ^c   Chêne, Geneviève ^a,b,e  

^a Centre of Clinical Investigation Clinical Epidemiology   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c HENRI MONDOR HOSPITAL   (France)

^d International Scientific and Clinical Affairs   (France)

^e BORDEAUX UNIVERSITY HOSPITAL   (France)

Author keywords

endpoint; HIV infection; proportional odds model; random effect; statistical power; Vaccine

Indexed keywords

PNEUMO23; PNEUMOCOCCUS VACCINE; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CONTROLLED STUDY; DRUG DESIGN; DRUG RESEARCH; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOGENICITY; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; SEROTYPE; SIMULATION; STATISTICAL ANALYSIS; STATISTICAL MODEL; STREPTOCOCCUS PNEUMONIAE; SYSTEMATIC REVIEW;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIBODIES, BACTERIAL; DATA INTERPRETATION, STATISTICAL; HUMANS; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; RESEARCH DESIGN; STREPTOCOCCUS PNEUMONIAE; TREATMENT OUTCOME;

EID: 69949099323     PISSN: 08954356     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2008.10.014     Document Type: Article

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