3.3 Trovafloxacin: A case study of idiosyncratic or iatrogenic liver toxicity-molecular mechanisms and lessons for pharmacotoxicity

Human and Experimental Toxicology

Volumn 28, Issue 2-3, 2009, Pages 119-121

  Borlak, J ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GREPAFLOXACIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; REGULATOR PROTEIN; TEMAFLOXACIN; TROVAFLOXACIN;

CARDIOTOXICITY; CONFERENCE PAPER; DNA FOOTPRINTING; DNA MICROARRAY; GENE EXPRESSION; HUMAN; LIVER CELL; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG-INDUCED LIVER INJURY; FLUOROQUINOLONES; GENE EXPRESSION REGULATION; GENES; HEPATOCYTES; HUMANS; IATROGENIC DISEASE; NAPHTHYRIDINES;

EID: 69949092077     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327109105767     Document Type: Conference Paper

References (5)

1. Thum T, Borlak J. Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes. Arch Toxicol 2008 ; 82: 89-101.
2. Waring JF, Liguori MJ, Luyendyk JP, Maddox JF, Ganey PE, Stachlewitz RF. Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils. J Pharmacol Exp Ther 2006 ; 316: 1080-1087.
3. Liguori MJ, Anderson MG, Bukofzer S, McKim J, Pregenzer JF, Retief J. Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin. Hepatology 2005 ; 41: 177-186.
4. Meier T, Reymann S,Niehof M,Borlak J; . Unraveling trovafloxacins molecular basis of hepatotoxicity (submitted).
5. http://www.emea.europa.eu/pdfs/human/swp/15011506en.pdf