Expression of EBV latent antigens, mammalian target of rapamycin, and tumor suppression genes in EBV-positive smooth muscle tumors: Clinical and therapeutic implications

Clinical Cancer Research

Volumn 15, Issue 17, 2009, Pages 5350-5358

  Ong, Kong Wee ^a   Teo, Marissa ^a   Lee, Victor ^b   Ong, Danny ^a   Lee, Ann ^a   Chieh, Suai Tan ^c   Vathsala, A ^b   Toh, Han Chong ^a  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^c SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; DEATH ASSOCIATED PROTEIN KINASE; EPSTEIN BARR VIRUS ANTIGEN; GLUTATHIONE TRANSFERASE P1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; PROTEIN KINASE B; PROTEIN P14; RAPAMYCIN; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RETINOIC ACID RECEPTOR BETA; S6 KINASE; VASCULOTROPIN;

ADULT; ANTIGEN EXPRESSION; ARTERY DISEASE; ARTICLE; CANCER SURGERY; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG WITHDRAWAL; FEMALE; GENE EXPRESSION; GRAFT RECIPIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LIVER TUMOR; MALE; METHYLATION; MUSCLE TUMOR; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOUTHERN BLOTTING; TUMOR REGRESSION; TUMOR SUPPRESSOR GENE;

ADULT; ANTIGENS, VIRAL; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; GLUTATHIONE S-TRANSFERASE PI; HERPESVIRUS 4, HUMAN; HUMANS; KIDNEY TRANSPLANTATION; MALE; METHYLATION; MIDDLE AGED; PROMOTER REGIONS, GENETIC; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, RETINOIC ACID; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SMOOTH MUSCLE TUMOR; TUMOR SUPPRESSOR PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 69949091379     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-2979     Document Type: Article

References (48)

1. Sprangers B, Smets S, Sagaert X, et al. Post-transplant Epstein-Barr virus-associated myogenic tumors: case report and review of the literature. Am J Transplant 2008;8:253-258
2. Klein E, Kis LL, Klein G. Epstein-Barr virus infection in humans: from harmless to life endangering virus-lymphocyte interactions. Oncogene 2007;26:1297-1305 (Pubitemid 46328467)
3. Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000;103:253-262
4. Stallone G, Schena A, Infante B, et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 2005;352:1317-1323 (Pubitemid 40411498)
5. Toh HC, Teo M, Ong KW, et al. Complete remission of an EBV positive smooth muscle tumour treated with sirolimus. Lancet Oncol 2006;7:955-957
6. Lo KW, Huang DP. Genetic and epigenetic changes in nasopharyngeal carcinoma. Semin Cancer Biol 2002;12:451-462
7. Kwong J, Lo KW, To KF, Teo PM, Johnson PJ, Huang DP. Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin Cancer Res 2002;8:131-137 (Pubitemid 34101468)
8. Deyrup AT, Lee V, Hill CE, et al. Epstein-Barr Virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol 2006;30:75-82. (Pubitemid 43740212)
9. Luo B, Wang Y, Wang XF, et al. Expression of Epstein-Barr Virus genes in EBV-associated gastric carcinomas. World J Gastroenterol 2005;11:629-633 (Pubitemid 40220748)
10. Conacher M, Callard R, McAulay K, et al. Epstein-Barr virus can establish infection in the absence of a classical Memory B-cell population. J Virol 2005;79:11128-11134 (Pubitemid 41170653)
11. Sample J, Young L, Martin B, et al. Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes. J Virol 1990;64:4084-4092 (Pubitemid 20279813)
12. Deyrup AT. Epstein-Barr virus-associated epithelial and mesenchymal neoplasms. Hum Pathol 2008;39:473-483
13. Lorenzo F, Fraser R, Gaboury L, Mulder D. Epstein-Barr virus-associated pulmonary leiomyosarcoma arising twenty-nine years after renal transplantation. J Thorac Cardiovasc Surg 2003;126:877-879 (Pubitemid 37151987)
14. Lee ES, Locker J, Nalesnik M, et al. The association of Epstein-Barr virus with smooth muscle tumours occurring after organ transplantation. N Engl J Med 1995;332:19-25.
15. Brichard B, Smets F, Sokal E, et al. Unusual evolution of an Epstein-Barr virus-associated leiomyosarcoma occurring after liver transplantation. Pediatr Transplant 2001;5:365-369 (Pubitemid 32834805)
16. To KF, Lai FMM, Wang AY, et al. Posttransplant Epstein-Barr virus-associated myogenic tumors involving bone. Cancer 2000;9:467-472
17. Kingma DW, Shad A, Tsokos M, et al. Epstein-Barr virus (EBV)-associated smooth muscle tumor arising in a post-transplant patient treated successfully for two PT-EBV-associated large-cell lymphomas. Am J Surg Pathol 1996;20:1511-1519 (Pubitemid 26411720)
18. Boman F, Gultekin H, Dickman PS. Latent Epstein-Barr virus infection demonstrated in low-grade leiomyosarcomas of adults with acquired immunodeficiency syndrome, but not in adjacent Kaposi's lesion or smooth muscle tumors in immunocompetent patients. Arch Pathol Lab Med 1997;121:834-838 (Pubitemid 27357577)
19. Rogatsch H, Bonatti H, Menet A, Larcher C, Feichtinger H, Dirnhofer S. Epstein-Barr Virus-associated multicentric leiomyosarcoma in an adult patient after heart transplantation. Case report and review of the literature. Am J Surg Pathol 2000;24:614-621 (Pubitemid 30180757)
20. Suankratay C, Shuangshoti S, Mutirangura A, et al. Epstein-Barr virus infection-associated smooth-muscle tumors in patients with AIDS. HIV/AIDS 2005;40:1521-1528 (Pubitemid 40628643)
21. Creager AJ, Maia DM, Funkhouser WK. Epstein-Barr Virus-associated renal smooth muscle neoplasm. Report of a case with review of the literature. Arch Pathol Lab Med 1998;122:277-281
22. McClain KL, Leach CT, Jenson HB, et al. Association of Epstein-Barr virus with leiomyosarcomas in children with AIDS. N Engl J Med 1995;332:12-18
23. Busson P, Ganem G, Flores P, et al. Establishment and characterization of three transplantable EBV-containing nasopharyngeal carcinomas. Int J Cancer 1988;42:599-606 (Pubitemid 18264074)
24. Borza CM, Hutt-Fletcher LM. Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus. Nature Med 2002;8:594-599 (Pubitemid 34633437)
25. Lo YMD, Chan LYS, Lo KW, et al. Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer Res 1999;59:1188-1191 (Pubitemid 29136244)
26. Jenson HB, Montalvo EA, McClain KL, et al. Characterization of natural Epstein-Barr virus infection and replication in smooth muscle cells from a leiomyosarcoma. J Med Virol 1999;57:36-46.
27. Young L, Alfieri C, Hennessey K, et al. Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. N Engl J Med 1989;321:1080-1085 (Pubitemid 19256661)
28. Haque T, Wilkie GM, Taylor C, et al. Treatment of Epstein-Barr-virus- positive post-transplantation lymphoproliferative disease with partly HLA-matched allogeneic cytotoxic T cells. Lancet 2002;360:436-442 (Pubitemid 34880139)
29. Griffin BE. Epstein-Barr virus (EBV) and human disease: facts, opinions and problems. Mutat Res 2000;462:395-405.
30. Morrison JA, Klingelhutz AJ, Raab-Traub N. Epstein-Barr virus latent membrane protein 2A activates β-catenin signaling in epithelial cells. J Virol 2003;77:12276-12284 (Pubitemid 37339880)
31. Brown EJ, Albers MW, Shin TB, Keith CT, Lane WS, Schreiber SL. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 1994;369:756-758 (Pubitemid 24225367)
32. Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994;78:35-43. (Pubitemid 24228298)
33. Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol 2005;17:596-603.
34. Hara K, Maruki Y, Long X, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002;110:177-189 (Pubitemid 34876546)
35. Sarbassov DD, Ali SM, Kim DH, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004;14:1296-1302
36. Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A 2001;98:10314-10319 (Pubitemid 32803017)
37. Kim DH, Sarbassov DD, Ali SM, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002;110:163-175
38. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-1101
39. Hernando E, Charytonowicz E, Dudas ME, et al. The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat Med 2007;13:748-753 (Pubitemid 46889749)
40. Moody CA, Scott RS, Amirghahari N, et al. Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A. J Virol 2005;79:5499-5506 (Pubitemid 40548218)
41. 6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 2000;60:2368-2371
42. Kang GH, Lee S, Kim WH, et al. Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 2002;160:787-794 (Pubitemid 34224568)
43. Man C, Rosa J, Lee LT, et al. Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells. Oncogene 2007;26:3069-3080 (Pubitemid 46733640)
44. Deiss LP, Feinstein E, Berissi H, Cohen O, Kinchi A. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the γ interferon-induced cell death. Genes Dev 1995;9:15-30.
45. Sanchez-Cespedes M, Esteller M, Wu L, et al. Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res 2000;60:892-895 (Pubitemid 30129522)
46. Blomhoff R, Green MH, Green JB, Berg T, Norum KR. Vitamin A metabolism: new perspectives on absorption, transport, and storage. Physiol Rev 1991;71:951-990
47. Kwong J, Lo KW, Chow LS, et al. Epigenetic silencing of cellular retinol-binding proteins in nasopharyngeal carcinoma. Neoplasia 2005;7:67-74. (Pubitemid 40209472)
48. Chan AT, Robertson KD, Flinn IW, et al. Azacitadine induces demethylation of the Epstein-Barr virus genome in tumors. J Clin Oncol 2004;22:1373-1381