Depiction of hypervascular hepatocellular carcinoma with 64-MDCT: Comparison of moderate- and high-concentration contrast material with and without saline flush

American Journal of Roentgenology

Volumn 193, Issue 3, 2009, Pages 738-744

  Matoba, Munetaka ^a   Kitadate, Masataka ^a   Kondou, Tamaki ^a   Yokota, Hajime ^a   Tonami, Hisao ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Contrast medium; CT; Hepatocellular carcinoma; Liver

Indexed keywords

IOHEXOL; IOPAMIDOL; SODIUM CHLORIDE;

ADULT; AGED; AORTA; ARTICLE; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER PARENCHYMA; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PORTAL VEIN; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TUMOR VASCULARIZATION;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CARCINOMA, HEPATOCELLULAR; CHI-SQUARE DISTRIBUTION; CONTRAST MEDIA; FEMALE; HUMANS; IOHEXOL; IOPAMIDOL; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SODIUM CHLORIDE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 69949091305     PISSN: 0361803X     EISSN: None     Source Type: Journal    
DOI: 10.2214/AJR.08.2028     Document Type: Article

References (31)

1. Bae KT. Peak contrast enhancement in CT and MR angiography: when does it occur and why? Pharmacokinetic study in a porcine model. Radiology 2003; 227:809-816
2. Hwang GJ, Kim MJ, Yoo HS, Lee JT. Nodular hepatocellular carcinomas: detection with arterial-, portal-, and delayed-phase images at spiral CT. Radiology 1997; 202:383-388
3. Mitsuzaki K, Yamashita Y, Ogata I, Nishiharu T, Urata J, Takahashi M. Multiple-phase helical CT of the liver for detecting small hepatomas in patients with liver cirrhosis: contrast-injection protocol and optimal timing. AJR 1996; 167:753-757 (Pubitemid 26279730)
4. Bae KT, Heiken JP, Brink JA. Aortic and hepatic peak enhancement at CT: effect of contrast medium injection rate - pharmacokinetic analysis and experimental porcine model. Radiology 1998; 206:455-464 (Pubitemid 28112962)
5. Yamashita Y, Komohara Y, Takahashi M, et al. Abdominal helical CT: evaluation of optimal doses of intravenous contrast material - a prospective randomized study. Radiology 2000; 216:718-723 (Pubitemid 30660843)
6. Awai K, Takada K, Onishi H, Hori S. Aortic and hepatic enhancement and tumor-to-liver contrast: analysis of the effect of different concentrations of contrast material at multi-detector row helical CT. Radiology 2002; 224:757-763 (Pubitemid 34919809)
7. Furuta A, Ito K, Fujita T, Koike S, Shimizu A, Matunaga N. Hepatic enhancement in muiltiphasic contrast-enhanced MDCT: comparison of high- and low-iodine-concentration contrast medium in same patients with chronic liver disease. AJR 2004; 183:157-162 (Pubitemid 38789030)
8. Yagyu Y, Awai K, Inoue M, et al. MDCT of hypervascular hepatocellular carcinoma: a prospective study using contrast materials with different iodine concentrations. AJR 2005; 184:1535-1540 (Pubitemid 43821832)
9. Heiken JP, Brink JA, McClennan BL, Sagel SS, Crowe TM, Gaines MV. Dynamic incremental CT: effect of volume and concentration of contrast material and patient weight on hepatic enhancement. Radiology 1995; 195:353-357
10. Brink JA, Heiken JP, Forman HP, Sagel SS, Molina PL, Brown PC. Hepatic spiral CT: reduction of dose intravenous contrast material. Radiology 1995; 197:83-88
11. Awai K, Hiraishi K, Hori S, et al. Effect of contrast material injection duration and rate on aortic peak time and peak enhancement at dynamic CT involved injection protocol with dose tailored to patient weight. Radiology 2004; 230:142-150 (Pubitemid 37549795)
12. Han JK, Kim AY, Lee KY, et al. Factors influencing vascular and hepatic enhancement at CT: experimental study on injection protocol using a canine model. J Comput Assist Tomogr 2000; 24:400-406
13. Awai K, Inoue M, Yagyu Y, et al. Moderate versus high concentration of contrast material for aortic and hepatic enhancement and tumor-to-liver contrast at multi-detector row CT. Radiology 2004; 233:682-688
14. Suzuki H, Oshima H, Shiraki N, Ikeya C, Shibamoto Y. Comparison of two contrast materials with different iodine concentrations in enhancing the density of the aorta, portal vein and liver at multi-detector row CT: a randomized study. Eur Radiol 2004; 14:2099-2104 (Pubitemid 39481184)
15. Dorio PJ, Lee FT Jr, Henseler KP, et al. Using a saline chaser to decrease contrast media in abdominal CT. AJR 2003; 180:929-934
16. Orlandini F, Boini S, Duchamps SI, Batch T, Zhu X, Blum A. Assessment of the use of a saline chaser to reduce the volume of contrast medium in abdominal CT. AJR 2006; 187:511-515 (Pubitemid 44148296)
17. Itoh S, Ikeda M, Achiwa M, Ota T, Satake H, Ishigaki T. Multiphase contrast-enhanced CT of the with a multislice CT scanner. Eur Radiol 2003; 13:1085-1094
18. Haage P, Schmitz-Rode T, Hubner D, Piroth W, Gunther RW. Reduction of contrast material dose and artifacts by a saline flush using a double power injector in helical CT of the thorax. AJR 2000; 174:1049-1053 (Pubitemid 30180001)
19. Hirano T, Ogura K, Kumagai A, et al. Contrast injection protocols using dual head injector. Jpn J Radiol Technol 2003; 59:247-248
20. Bae KT, Heilen JP, Brink JA. Aortic and hepatic contrast medium enhancement at CT. Part 1. Prediction with a computer model. Radiology 1998; 207:647-655 (Pubitemid 28279895)
21. Murakami T, Kim T, Takamura M, et al. Hypervascular hepatocellular carcinoma: detection with double arterial phase multi-detector row helical CT. Radiology 2001; 218:763-767 (Pubitemid 32172560)
22. Kim T, Murakami T, Hori M, et al. Small hypervascular hepatocellular carcinoma revealed by double arterial phase CT performed with single breath-hold scanning and automatic bolus tracking. AJR 2002; 178:899-904 (Pubitemid 34250226)
23. Foley WD, Mallisee TA, Hohenwalter MD, Wilson CR, Quiroz FA, Taylor AJ. Multiphase hepatic CT with a multirow detector CT scanner. AJR 2000; 175:679-685
24. Ichikawa T, Kitamura T, Nakajima H, et al. Hypervascular hepatocellular carcinoma: can double arterial phase imaging with multidetector CT improve tumor depiction in the cirrhotic liver? AJR 2002; 179:751-758 (Pubitemid 34919593)
25. Yanaga Y, Awai K, Nakayama Y, et al. Optimal dose and injection duration (injection rate) of contrast material for depiction of hypervascular hepatocellular carcinomas by multidetector CT. Radiat Med 2007; 25:278-288 (Pubitemid 351928041)
26. Baron RL, Oliver JH, Dodd GD III, et al. Hepatocellular carcinoma: evaluation with biphasic, contrast-enhanced, helical CT. Radiology 1996; 199: 505-511 (Pubitemid 26122003)
27. Hollett MD, Jeffrey RB Jr, Nino-Murcia M, et al. Dual-phase helical CT of the liver: value of arterial phase scans in the detection of small (≤ 1.5 cm) malignant hepatic neoplasms. AJR 1995; 164:879-884
28. Kuszyk BS, Bluemke DA, Urban BA, et al. Portal-phase contrast-enhanced helical CT for the detection of malignant hepatic tumors: sensitivity based on comparison with intraoperative and pathologic findings. AJR 1996; 166:91-95
29. Sultana S, Awai K, Nakayama Y, et al. Hypervascular hepatocellular carcinoma: bolus tracking with a 40-detector CT scanner to time arterial phase imaging. Radiology 2007; 243:140-147 (Pubitemid 46579704)
30. Matoba M, Kondou T, Yokota H, Higashi K, Tonami H. Usefulness of a saline flush for intravenous 3-dimensional computed tomography portography using multidetector-row helical computed tomography. J Comput Assist Tomogr 2005; 29:780-785 (Pubitemid 41689541)
31. Tatsugami F, Matsuki M, Kani H, et al. Effect of saline pushing after contrast material injection in abdominal; multidetector computed tomography with the use of different iodine concentrations. Acta Radiol 2006; 47:192-197 (Pubitemid 43328795)