Immunohistochemical expression of S100A6 in cellular neurothekeoma: Clinicopathologic and immunohistochemical analysis of 31 cases

American Journal of Dermatopathology

Volumn 31, Issue 5, 2009, Pages 419-422

  Plaza, Jose Antonio ^a,b   Torres Cabala, Carlos ^c   Evans, Harry ^c   Diwan, A Hafeez ^c   Prieto, Victor G ^c  

^a Departments of Pathology   (Japan)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Cellular neurothekeoma; Neurothekeoma; S100A6 neurothekeoma

Indexed keywords

CALCYCLIN; CYTOKERATIN; EPITHELIAL MEMBRANE ANTIGEN; FORMALDEHYDE; HMB 45 ANTIGEN; KERATIN; MELAN A; PARAFFIN; PROTEIN S 100; SMOOTH MUSCLE ACTIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; S100A6 PROTEIN, HUMAN; TUMOR MARKER;

ADOLESCENT; ADULT; ARTICLE; AXILLA; CELL LABELING; CELL PROLIFERATION; CHEEK; CHILD; CLINICAL ARTICLE; EYEBROW; FEMALE; FINGER; FOREARM; HAND TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEG; MALE; MOUTH TUMOR; NEUROTHEKEOMA; NOSE TUMOR; PATHOLOGY; PELVIS TUMOR; PENIS TUMOR; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCALP TUMOR; SCHOOL CHILD; SHOULDER; SKIN CELL; SPINDLE CELL; THIGH; THORAX TUMOR; TISSUE SECTION; TOE; WRIST; BIOSYNTHESIS; DIFFERENTIAL DIAGNOSIS; IMMUNOPHENOTYPING; MELANOMA; METABOLISM; MIDDLE AGED;

ADOLESCENT; ADULT; CELL CYCLE PROTEINS; CHILD; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MALE; MELANOMA; MIDDLE AGED; NEUROTHEKEOMA; S100 PROTEINS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 69849108109     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e3181a13afc     Document Type: Article

References (23)

1. Harkin JC RR, editor. Solitary benign nerve sheath tumors. Washington, DC: Armed Forces Institute of Pathology; 1969.
2. Gallager RL, Helwig EB. Neurothekeoma-a benign cutaneous tumor of neural origin. Am J Clin Pathol. 1980;74:759-764.
3. Argenyi ZB, LeBoit PE, Santa Cruz D, et al. Nerve sheath myxoma (neurothekeoma) of the skin: light microscopic and immunohistochemical reappraisal of the cellular variant. J Cutan Pathol. 1993;20:294-303.
4. Argenyi ZB, Kutzner H, Seaba MM. Ultrastructural spectrum of cutaneous nerve sheath myxoma/cellular neurothekeoma. J Cutan Pathol. 1995;22:137-145.
5. Barnhill RL, Mihm MC Jr. Cellular neurothekeoma. A distinctive variant of neurothekeoma mimicking nevomelanocytic tumors. Am J Surg Pathol. 1990;14:113-120.
6. Ribe A, McNutt NS. S100A6 protein expression is different in Spitz nevi and melanomas. Mod Pathol. 2003;16:505-511.
7. Ilg EC, Schafer BW, Heizmann CW. Expression pattern of S100 calcium-binding proteins in human tumors. Int J Cancer. 1996;68:325-332.
8. Donato R. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochim Biophys Acta. 1999;1450:191-231.
9. Fullen DR, Lowe L, Su LD. Antibody to S100a6 protein is a sensitive immunohistochemical marker for neurothekeoma. J Cutan Pathol. 2003; 30:118-122.
10. Rosati LA, Fratamico FC, Eusebi V. Cellular neurothekeoma. Appl Pathol. 1986;4:186-191.
11. Calonje E, Wilson-Jones E, Smith NP, et al.'Cellular neurothekeoma': an epithelioid variant of pilar leiomyoma? Morphological and immunohis-tochemical analysis of a series. Histopathology. 1992;20:397-404.
12. Busam KJ, Mentzel T, Colpaert C, et al. Atypical or worrisome features in cellular neurothekeoma: a study of 10 cases. Am J Surg Pathol. 1998;22: 1067-1072.
13. Husain S, Silvers DN, Halperin AJ, et al. Histologic spectrum of neurothekeoma and the value of immunoperoxidase staining for S-100 protein in distinguishing it from melanoma. Am J Dermatopathol. 1994; 16:496-503.
14. Hornick JL, Fletcher CD. Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol. 2007;31:329-340.
15. Fetsch JF, Laskin WB, Hallman JR, et al. Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol. 2007;31:1103-1114.
16. Wang AR, May D, Bourne P, et al. PGP9.5: a marker for cellular neurothekeoma. Am J Surg Pathol. 1999;23:1401-1407.
17. Banerjee SS, Agbamu DA, Eyden BP, et al. Clinicopathological characteristics of peripheral primitive neuroectodermal tumour of skin and subcutaneous tissue. Histopathology. 1997;31:355-366.
18. Sachdev R, Sundram UN. Frequent positive staining with NKI/C3 in normal and neoplastic tissues limits its usefulness in the diagnosis of cellular neurothekeoma. Am J Clin Pathol. 2006;126:554-563.
19. Page RN, King R, Mihm MC Jr, et al. Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma. Mod Pathol. 2004;17: 230-234.
20. Campbell LK, Thomas JR, Lamps LW, et al. Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms. Mod Pathol. 2003;16:963-969.
21. Fullen DR, Reed JA, Finnerty B, et al. S100A6 expression in fibrohistiocytic lesions. J Cutan Pathol. 2001;28:229-234.
22. Calabretta B, Battini R, Kaczmarek L, et al. Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein. J Biol Chem. 1986;261:12628-12632.
23. Ribe A, McNutt NS. S100A protein expression in the distinction between lentigo maligna and pigmented actinic keratosis. Am J Dermatopathol. 2003;25:93-99.