Diffusion-Weighted Imaging in Preclinical Leigh Syndrome

Pediatric Neurology

Volumn 41, Issue 4, 2009, Pages 309-311

  Kumakura, Akira ^a   Asada, Junko ^a   Okumura, Ryosuke ^a   Fujisawa, Ichiro ^b   Hata, Daisuke ^a  

^a Kitano Hospital   (Japan)

^b Kishiwada City Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; PHENOBARBITAL;

APNEA; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID LEVEL; CHILD; CLONIC SEIZURE; COMA; CONSCIOUSNESS DISORDER; DETERIORATION; DIFFUSION TENSOR IMAGING; FEEDING DISORDER; GLOBUS PALLIDUS; HUMAN; INTRAUTERINE GROWTH RETARDATION; LEIGH DISEASE; MALE; MISSENSE MUTATION; MYOCLONUS SEIZURE; PARIETAL LOBE; PONS; PREMATURITY; PRESCHOOL CHILD; PRIORITY JOURNAL; SUBSTANTIA NIGRA; TEGMENTUM; THALAMUS; WHITE MATTER;

APNEA; BRAIN; CHILD, PRESCHOOL; CONSCIOUSNESS DISORDERS; DIAGNOSIS, DIFFERENTIAL; DIFFUSION MAGNETIC RESONANCE IMAGING; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; EPILEPSIES, MYOCLONIC; HUMANS; INFANT; LEIGH DISEASE; MALE; PARENTS;

EID: 69849103748     PISSN: 08878994     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pediatrneurol.2009.04.028     Document Type: Article

References (10)

1. Cowan F.M., Pennock J.M., Hanrahan J.D., Manji K.P., and Edwards A.D. Early detection of cerebral infarction and hypoxic ischemic encephalopathy in neonates using diffusion-weighted magnetic resonance imaging. Neuropediatrics 25 (1994) 172-175
2. Takeoka M., Soman T.B., Yoshii A., et al. Diffusion-weighted images in neonatal cerebral hypoxic-ischemic injury. Pediatr Neurol 26 (2002) 274-281
3. Barkovich A.J. Toxic and metabolic brain disorders. In: Barkovich A.J. (Ed). Pediatric neuroimaging. 4th ed (2005), Lippincott, Williams and Wilkins, Philadelphia 141-155
4. Watanabe H., Nishikawa N., Inukai A., et al. An autopsy of case of Leigh disease: Pathology associated with increased signal intensity on diffusion-weighted magnetic resonance imaging. Neuropathology 22 (2002) A44
5. DiMauro S., and Schon E.A. mechanisms of disease: Mitochondrial respiratory-chain diseases. N Engl J Med 348 (2003) 2656-2668
6. Abe K., Yoshimura H., Tanaka H., Fujita N., Hikita T., and Sakoda S. Comparison of conventional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like events. Neuroradiology 46 (2004) 113-117
7. Sacher M., Fatterpekar G.M., Edelstein S., Sansaricq C., and Naidich T.P. MRI findings in an atypical case of Kearns-Sayre syndrome: A case report. Neuroradiology 47 (2005) 241-244
8. Ulmer S., Flemming K., Hahn A., Stephani U., and Jansen O. Detection of acute cytotoxic changes in progressive neuronal degeneration of childhood with liver disease (Alpers-Huttenlocher syndrome) using diffusion-weighted MRI and MR spectroscopy. J Comput Assist Tomogr 26 (2002) 641-646
9. Oguz K.K., Ozturk A., and Cila A. Diffusion-weighted MR imaging and MR spectroscopy in glutaric aciduria type 1. Neuroradiology 47 (2005) 229-234
10. Loeffen J., Smeitink J., Trijbels J., et al. Insolated complex I deficiency in children: Clinical, biochemical and genetic aspects. Hum Mutat 15 (2000) 123-134