Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences

Journal of Translational Medicine

Volumn 7, Issue , 2009, Pages

  Mizrahi, Aya ^a   Czerniak, Abraham ^b   Levy, Tally ^c   Amiur, Smadar ^a   Gallula, Jennifer ^a   Matouk, Imad ^a   Abu lail, Rasha ^a   Sorin, Vladimir ^c   Birman, Tatiana ^a   de Groot, Nathan ^a   Hochberg, Abraham ^a   Ohana, Patricia ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c WOLFSON MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CA 125 ANTIGEN; DIPHTHERIA TOXIN; PLASMID VECTOR; RNA H19; UNTRANSLATED RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES FLUID; CANCER CELL DESTRUCTION; CANCER GENE THERAPY; CANCER INHIBITION; CANCER MODEL; CELL KILLING; CONTROLLED STUDY; FEMALE; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENE VECTOR; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; IN VITRO GENE TRANSFER; MOUSE; NONHUMAN; OVARY CANCER; REGULATORY SEQUENCE; RNA PROBE; ANIMAL; ASCITES; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER; GENETICS; METABOLISM; METHODOLOGY; NUDE MOUSE; OVARY TUMOR; PATHOLOGY; PLASMID; TUMOR CELL LINE;

ANIMALS; ASCITES; CELL LINE, TUMOR; DIPHTHERIA TOXIN; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TARGETING; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; MICE; MICE, NUDE; OVARIAN NEOPLASMS; PLASMIDS; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, UNTRANSLATED;

EID: 69849100347     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-7-69     Document Type: Article

References (32)

1. NCI National Cancer Institute http://www.cancer.gov/cancertopics/types/ ovarian
2. Cannistra SA Cancer of the ovary N Engl J Med 2004, 351:2519-2529. 10.1056/NEJMra041842 15590954
3. McGonigle KF Dudzinski MR Endometrioid carcinoma of the ovary presenting with an enlarged inguinal lymph node without evidence of abdominal carcinomatosis Gynecol Oncol 1992, 45:225-228. 10.1016/ 0090-8258(92)90291-P 1592293
4. Berkenblit A Cannistra SA Advances in the management of epithelial ovarian cancer J Reprod Med 2005, 50:426-38. 16050567
5. Louis MH Dutoit S Denoux Y Erbacher P Deslandes E Behr JP Gauduchon P Poulain L Intraperitoneal linear polyethylenimine (L-PEI)-mediated gene delivery to ovarian carcinoma nodes in mice Cancer Gene Ther 2006, 13:367-74. 10.1038/sj.cgt.7700893 16167064
6. Jandu N Richardson M Singh G Hirte H Hatton MW Human ovarian cancer ascites fluid contains a mixture of incompletely degraded soluble products of fibrin that collectively possess an antiangiogenic property Int J Gynecol Cancer 2006, 16:1536-44. 10.1111/j.1525-1438.2006.00624.x 16884362
7. Ruan H Su H Hu L Lamborn KR Kan YW Deen DF A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy Neoplasia 2001, 3:255-263. 10.1038/sj.neo.7900157 1505593 11494119
8. Gu J Fang B Telomerase promoter-driven cancer gene therapy Cancer Biol Ther 2003, 2:S64-S70. 14508082
9. Erdmann VA Barciszewska MZ Szymanski M Hochberg A de Groot N Barciszewski J The non-coding RNAs as riboregulators Nucl Acids Res 2001, 29:189-193. 10.1093/nar/29.1.189 29806 11125087
10. Ariel I Lustig O Schneider T Pizov G Sappir M De-Groot N Hochberg A The imprinted H19 gene as a tumor marker in bladder carcinoma Urology 1995, 45:335-338. 10.1016/0090-4295(95)80030-1 7855987
11. Ariel I Miao HQ Ji XR Schneider T Roll D de Groot N Hochberg A Ayesh S Imprinted H19 oncofetal RNA is a candidate tumour marker for hepatocellular carcinoma Mol Pathol 1998, 51:21-25. 10.1136/mp.51.1.21 395603 9624415
12. Ayesh S Matouk I Schneider T Ohana P Laster M Al-Sharef W De-Groot N Hochberg A The possible physiological role of H19 RNA Mol Carcinog 2002, 35:63-74. 10.1002/mc.10075 12325036
13. Matouk IJ DeGroot N Mezan S Ayesh S Abu-lail R Hochberg A Galun E The H19 non-coding RNA is essential for human tumor growth PLoS ONE 2007, 2:e845. 10.1371/journal.pone.0000845 1959184 17786216
14. Leighton PA Ingram RS Eggenschwiler J Efstratiadis A Tilghman SM Disruption of imprinting caused by deletion of the H19 gene in mice Nature 1995, 375:34-39. 10.1038/375034a0 7536897
15. Ariel I Sughayer M Fellig Y Pizov G Ayesh S Podeh D Libdeh BA Levy C Birman T Tykocinski ML de Groot N Hochberg A The imprinted H19 gene is a marker of early recurrence in human bladder carcinoma Mol Pathol 2000, 53:320-3. 10.1136/mp.53.6.320 1186987 11193051
16. Lustig-Yariv O Schulze E Komitowski D Erdmann V Schneider T de Groot N Hochberg A The expression of the imprinted genes H19 and IGF-2 in choriocarcinoma cell lines. Is H19 a tumor suppressor gene? Oncogene 1997, 5:169-77. 10.1038/sj.onc.1201175
17. Cui H Onyango P Brandenburg S Wu Y Hsieh CL Feinberg AP, Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2 Cancer Res 2002, 62:6442-6. 12438232
18. Kaplan R Luettich K Heguy A Hackett NR Harvey BG Crystal RG Monoallelic up-regulation of the imprinted H19 gene in airway epithelium of phenotypically normal cigarette smokers Cancer Res 2003, 63:1475-82. 12670893
19. Tanos V Prus D Ayash S Weinstein D Tykocinski ML De-Groot N Hochberg A Ariel I Expression of the imprinted H19 oncofetal RNA in epithelial ovarian cancer Eru J Obstet Gynecol Reprod Biol 1999, 85:7-11. 10.1016/ S0301-2115(98)00275-9
20. Breitman ML Clapoff S Rossant J Tsui LC Glode LM Maxwell IH Bernstein A Genetic ablation: Targeted expression of a toxin gene causes microphthalmia in transgenic mice Science 1987, 238:1563-1565. 10.1126/ science.3685993 3685993
21. Pastan I Chaudhary V FitzGerald DJ Recombinant toxins as novel therapeutic agents Annu Rev Biochem 1992, 61:331-354. 10.1146/ annurev.bi.61.070192.001555 1497314
22. Ohana P Schachter P Ayesh B Mizrahi A Birman T Schneider T Matouk I Ayesh S Kuppen PJ de Groot N Czerniak A Hochberg A Regulatory sequences of H19 and IGF2 genes in DNA-based therapy of colorectal rat liver metastases J Gene Med 2005, 7:366-74. 10.1002/jgm.670 15521051
23. Ohana P Gofrit O Ayesh S Al-Sharef W Mizrahi A Birman T Schneider T Matouk I de Groot N Tavdy E Sidi A Hochberg A Regulatory sequences of the H19 gene in DNA based therapy of bladder cancer Gene Ther and Mol Biol 2004, 8:181-191.
24. Sidi A Ohana P Shalva B Shalev M Ransom J Lamm D Hochberg A Leibovitch I Phase I/II Marker Lesion Study of Intravesical BC-819 DNA Plasmid in H19 Overexpressing Superficial Bladder Cancer Refractory to Bacillus Calmette Guerin Am J of Urol 2008, 180:2379-2383. 10.1016/ j.juro.2008.08.006
25. Ohana P Kopf E Bibi O Ayesh S Schneider T Laster M Tykocinski M de Groot N Hochberg A The expression of the H19 gene and its function in human bladder carcinoma cell lines FEBS Lett 1999, 454:81-84. 10.1016/ S0014-5793(99)00780-2 10413100
26. Ayesh B Matouk I Ohana P Sughayer MA Birman T Ayesh S Schneider T de Groot N Hochberg A Inhibition of tumor growth by DT-A expressed under the control of IGF2 P3 and P4 promoter sequences Mol Ther 2003, 7:535-541. 10.1016/S1525-0016(03)00056-X 12727117
27. Wu L Johnson M Sato M Transcriptioanlly targeted gene therapy to detect and treat cancer Trends in Mol Med 2003, 9:421-429. 10.1016/ j.molmed.2003.08.005
28. Ohana P Bibi O Matouk I Levy C Birman T Ariel I Schneider T Ayesh S Giladi H Laster M de Groot N Hochberg A The use of H19 regulatory sequences for targeted gene therapy in cancer Int J Cancer 2001, 98:645-650. 10.1002/ijc.10243
29. Maxwell IH Glode LM Maxwell F Expression of diphtheria toxin A-chain in mature B-cells: A potential approach to therapy of B-lymphoid malignancy Leuk Lymphoma 1992, 7:457-462. 10.3109/10428199209049802 1493446
30. Elkin M Ayesh S Schneider T de Groot N Hochberg A Ariel I The dynamics of the imprinted H19 gene expression in the mouse model of bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl) nitrosamine Carcinogenesis 2099, 19:2095-1998. 10.1093/carcin/19.12.2095
31. Elkin M Shevelev A Schulze E Tykocinsky M Cooper M Ariel I Pode D Kopf E de Groot N Hochberg A The expression of the H19 and IGF-2 genes in human bladder carcinoma FEBS Lett 1995, 374:57-61. 10.1016/ 0014-5793(95)01074-O 7589512
32. Mislick KA Baldeschwieler JD Evidence for the role of proteogylcans in cation-mediated gene transfer Proc Natl Acad Sci USA 1996, 93:12349-12354. 10.1073/pnas.93.22.12349 37994 8901584