Globulixanthone F, a new polyoxygenated xanthone with an isoprenoid group and two antimicrobial biflavonoids from the stem bark of Symphonia globulifera

Natural Product Communications

Volumn 4, Issue 6, 2009, Pages 803-808

  Mkounga, Pierre ^a   Fomum, Zacharias T ^a   Meyer, Michèle ^b   Bodo, Bernard ^b   Nkengfack, Augustin E ^a  

^a UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

Antimicrobial activity; Biflavonoids; Globulixanthone F; Guttiferae; Symphonia globulifera; Synthesis of xanthone

Indexed keywords

1 HYDROXY 7 METHOXY 3 O A, A DIMETHYLALLYLXANTHONE; 1,3 DIHYDROXY 7 METHOXY 4 (3,3 DIMETHYLALLYL)XANTHONE; 3 (1,1 DIMETHYLPROP 2 YNYLOXY) 1 HYDROXY 7 METHOXYXANTHONE; BIFLAVONOID; BIFLAVONOID GB2; GENTAMICIN; GENTISEIN; GLOBULIXANTHONE F; ISOGENTISEIN; ISOPRENOID; MANNIFLAVANONE GB3; MBARRAXANTHONE; PLANT EXTRACT; STREPTOMYCIN SULFATE; SYMPHONIA GLOBULIFERA EXTRACT; UGAXANTHONE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE; ANTIINFECTIVE AGENT; FLAVONOID;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BARK; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HETERONUCLEAR MULTIPLE BOND CORRELATION; LISTONELLA ANGUILLARUM; MEDICINAL PLANT; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PLANT STEM; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; SYMPHONIA GLOBULIFERA; BACTERIUM; CHEMISTRY; DRUG EFFECT; GUTTIFERAE; MICROBIOLOGICAL EXAMINATION; MOLECULAR BIOLOGY;

CLUSIACEAE; SYMPHONIA GLOBULIFERA;

ANTI-INFECTIVE AGENTS; BACTERIA; CLUSIACEAE; FLAVONOIDS; MICROBIAL SENSITIVITY TESTS; MOLECULAR BIOLOGY; PLANT BARK; XANTHONES;

EID: 69849088423     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0900400613     Document Type: Article

References (15)

1. Aubreville A. (1950) Flore Soudano-Guinéenne A.O.F. Cameroun-A.E.F., Société d'Edition Géographique Maritime et Coloniales Paris, 148-150.
2. Nkengfack AE, Mkounga P, Fomum ZT, Meyer M, Bodo B. (2002) Globulixanthones A and B, two new cytotoxic xanthones with isoprenoid groups from the root bark of Symphonia globulifera. Journal of Natural Products, 65, 734-736.
3. Nkengfack AE, Mkounga P, Fomum ZT, Meyer M, Bodo B. (2002) Globulixanthones C, D and E, three prenylated xanthones with antimicrobial properties from the root bark of Symphonia globulifera. Phytochemistry, 61, 181-187. (Pubitemid 34976885)
4. Locksley HD, Moore I, Scheimann F. (1966) Extractives from Guttiferae. Part IV. Isolation and structure of ugaxanthone and mbarraxanthone from Symphonia globulifera L. F. Journal of Chemical Society, 2265-2269.
5. Atkinson JE, Gupta P, Lewis JR. (1969) Some phenolic constituents of Gentiana lutea. Tetrahedron, 24, 1507-1511.
6. Jackson B, Locksley HD, Scheinmann F. (1971) Extractives from Guttiferae. Part XXII. The isolation and structure of four novel biflavones from the heartwoods of Garcina buchanani Baker and Garcina eugenifolia. Journal of Chemical Society, 3791-3804.
7. Chrichton EG, Waterman PG. (1979) Mannifavanone, a new 3,8-linked flavanone dimer from the stem bark of Garcina mannii.. Phytochemistry, 18, 1555-1557.
8. Peres V, Nagem TJ. (1997) Trioxygenated naturally occurring xanthones Phytochemistry, 44, 191-214. (Pubitemid 27087916)
9. Nagem TJ, De Oliviera FF, Peres V. (2000) Tetraoxygenated naturally occurring xanthones. Phytochemistry, 55, 683-710.
10. Kamdem AF, Mulholland D, Wansi JD, Mbaze LM, Pwo R, Mpondo TN, Fomum ZT, Konig W, Nkengfack AE. (2006) Afzeliixanthones A and B, two prenylated xanthones from Garcinia afzelii Engl. (Guttiferae).Chemical & Pharmaceutical Bulletin, 54, 448-451.
11. 13C NMR spectra study of polyhydroxyxanthones. Tetrahedron 34, 2035-2038.
12. Mikriyannis A, Fesik S. (1982) Methoxy group conformation of phenyl methyl ethers in solution. Journal of the American Chemical Society, 104, 6462-6463.
13. Mikriyannis A, Knittel JJ. (1979) The conformational analysis of aromatic methoxy groups from carbon-13 chemical shifts and spin-lattice relaxation time Tetrahedron Letters, 30, 2753-2756.
14. Boonsong K, Chak S, Kanyawim K, Suwaporn L, Komkrit H, Nipa J, Supa H, Ngampong K. (2005) Inhibitory effects of 2-substituted-1-naphthol derivatives on cyclooxygenase I and II. Bioorganic and Medicinal Chemistry, 13, 2167-2175.
15. Mitscher LA. (1977) Separation and purification of antibiotics. Elsevier, Amsterdam, 463.