Vardenafil protects against myocardial and endothelial injuries after cardiopulmonary bypass

European Journal of Cardio-thoracic Surgery

Volumn 36, Issue 4, 2009, Pages 657-664

  Szabó, Gábor ^a,b   Radovits, Tamás ^a,b   Veres, Gábor ^a,b   Krieger, Nelli ^a   Loganathan, Sivakkanan ^a   Sandner, Peter ^c   Karck, Matthias ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c BAYER PHARMA AG   (Germany)

Author keywords

Cardiopulmonary bypass; Contractility; Endothelium; Ischaemia reperfusion; Vardenafil

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; GUANOSINE PHOSPHATE; VARDENAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOG; DRUG EFFECT; ENDOTHELIUM INJURY; EXTRACORPOREAL CIRCULATION; HEART ARREST; HEART FUNCTION; HEART MUSCLE INJURY; HEMODYNAMIC PARAMETERS; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; VASODILATATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARDIOPULMONARY BYPASS; CARDIOTONIC AGENTS; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DISEASE MODELS, ANIMAL; DOGS; DRUG EVALUATION, PRECLINICAL; ENDOTHELIUM, VASCULAR; HEMODYNAMICS; IMIDAZOLES; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MYOCARDIAL REPERFUSION INJURY; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PREANESTHETIC MEDICATION; SULFONES; TRIAZINES; VENTRICULAR FUNCTION, LEFT; VENTRICULAR FUNCTION, RIGHT;

EID: 69849087378     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2009.03.065     Document Type: Article

References (25)

1. Shabsigh R. Therapy of ED: PDE-5 inhibitors. Endocrine 23 (2004) 135-141
2. Galiè N., Ghofrani H.A., Torbicki A., Barst R.J., Rubin L.J., Badesch D., Fleming T., Parpia T., Burgess G., Branzi A., Grimminger F., Kurzyna M., Simonneau G., and Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 353 (2005) 2148-2157
3. Senzaki H., Smith C.J., Juang G.J., Isoda T., Mayer S.P., Ohler A., Paolocci N., Tomaselli G.F., Hare J.M., and Kass D.A. Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure. FASEB J 15 (2001) 1718-1726
4. Abdallah Y., Gkatzoflia A., Pieper H., Zoga E., Walther S., Kasseckert S., Schäfer M., Schlüter K.D., Piper H.M., and Schäfer C. Mechanism of cGMP-mediated protection in a cellular model of myocardial reperfusion injury. Cardiovasc Res 66 (2005) 123-131
5. Ockaili R., Salloum F., Hawkins J., and Kukreja R.C. Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits. Am J Physiol Heart Circ Physiol 283 (2002) H1263-H1269
6. Salloum F.N., Ockaili R.A., Wittkamp M., Marwaha V.R., and Kukreja R.C. Vardenafil: a novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels in rabbits. J Mol Cell Cardiol 40 (2006) 405-411
7. Gori T., Sicuro S., Dragoni S., Donati G., Forconi S., and Parker J.D. Sildenafil prevents endothelial dysfunction induced by ischemia and reperfusion via opening of adenosine triphosphate-sensitive potassium channels: a human in vivo study. Circulation 111 (2005) 742-746
8. Dias-Junior C.A., Souza-Costa D.C., Zerbini T., da Rocha J.B., Gerlach R.F., and Tanus-Santos J.E. The effect of sildenafil on pulmonary embolism-induced oxidative stress and pulmonary hypertension. Anesth Analg 101 (2005) 115-120
9. Milani E., Nikfar S., Khorasani R., Zamani M.J., and Abdollahi M. Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats. Comp Biochem Physiol C Toxicol Pharmacol 140 (2005) 251-255
10. Kukreja R.C., Ockaili R., Salloum F., Yin C., Hawkins J., Das A., and Xi L. Cardioprotection with phosphodiesterase-5 inhibition--a novel preconditioning strategy. J Mol Cell Cardiol 36 (2004) 165-173
11. Wallace A., Lam H.W., Nose P.S., Bellows W., Mangano D.T., and The Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Changes in systolic and diastolic ventricular function with cold cardioplegic arrest in man. J Card Surg 9 (1994) 497-502
12. Boyle Jr. E.M., Pohlman T.H., Cornejo C.J., and Verrier E.D. Endothelial cell injury in cardiovascular surgery: ischemia-reperfusion. Ann Thorac Surg 62 (1996) 1868-1875
13. Wan S., LeClerc J.L., and Vincent J.L. Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest 112 (1997) 676-692
14. Ishikura F., Beppu S., Hamada T., Khandheria B.K., Seward J.B., and Nehra A. Effects of sildenafil citrate (Viagra) combined with nitrate on the heart. Circulation 102 (2000) 2516-2521
15. Szabó G., Bährle S., Stumpf N., Sonnenberg K., Szabó E.E., Pacher P., Csont T., Schulz R., Dengler T.J., Liaudet L., Jagtap P.G., Southan G.J., Vahl C.F., Hagl S., and Szabó C. Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation. Circ Res 90 (2002) 100-106
16. Vinten-Johansen J., Sato H., and Zhao Z.Q. The role of nitric oxide and NO-donor agents in myocardial protection from surgical ischemic-reperfusion injury. Int J Cardiol 50 (1995) 273-281
17. Zweier J.L., and Talukder M.A. The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res 70 (2006) 181-190
18. Lincoln T.M., Komalavilas P., and Cornwell T.L. Pleiotropic regulation of vascular smooth muscle tone by cyclic GMP-dependent protein kinase. Hypertension 23 (1994) 1141-1147
19. Wedgwood S., Steinhorn R.H., Bunderson M., Wilham J., Lakshminrusimha S., Brennan L.A., and Black S.M. Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol 289 (2005) L660-L666
20. Farrow K.N., Groh B.S., Schumacker P.T., Lakshminrusimha S., Czech L., Gugino S.F., Russell J.A., and Steinhorn R.H. Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells. Circ Res 102 (2008) 226-233
21. 2+-activated and ATP-sensitive K+ channels in sildenafil-induced late cardioprotection. J Mol Cell Cardiol 44 (2008) 105-113
22. Salloum F., Yin C., Xi L., and Kukreja R.C. Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart. Circ Res 92 (2003) 595-597
23. Mankad P.S., Amrani M., Rothery S., Severs N.J., and Yacoub M.H. Relative susceptibility of endothelium and myocardial cells to ischaemia-reperfusion injury. Acta Physiol Scand 161 (1997) 103-112
24. Kharbanda R.K., Peters M., Walton B., Kattenhorn M., Mullen M., Klein N., Vallance P., Deanfield J., and MacAllister R. Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation 103 (2001) 1624-1630
25. Broadhead M.W., Kharbanda R.K., Peters M.J., and MacAllister R.J. KATP channel activation induces ischemic preconditioning of the endothelium in humans in vivo. Circulation 110 (2004) 2077-2082