Enantioselective analysis of praziquantel and trans-4-hydroxypraziquantel in human plasma by chiral LC-MS/MS: Application to pharmacokinetics

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 27, 2009, Pages 3083-3088

  Lima, Renata Monteiro ^a   Ferreira, Maria Augusta Drago ^b   Ponte, Teresa Maria de Jesus ^b   Marques, Maria Paula ^a   Takayanagui, Osvaldo Massaiti ^a   Garcia, Hector Hugo ^c   Coelho, Eduardo Barbosa ^a   Bonato, Pierina Sueli ^a   Lanchote, Vera Lucia ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^c INSTITUTO NACIONAL DE CIENCIAS NEUROLÓGICAS   (Peru)

Author keywords

Enantiomers; Metabolism; Pharmacokinetics; Praziquantel

Indexed keywords

AS EXTRACTION; CHIRAL LC; CHIRALPAK AD; CLINICAL STUDY; ENANTIOSELECTIVE; ENANTIOSELECTIVE ANALYSIS; HUMAN PLASMAS; INTERNAL STANDARDS; ISO-PROPANOLS; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; MOBILE PHASE; PLASMA SAMPLES; PRAZIQUANTEL; QUANTITATION LIMITS; SINGLE-DOSE;

BIOCHEMISTRY; CHIRALITY; ENANTIOMERS; ENANTIOSELECTIVITY; HEXANE; LIQUIDS; METABOLISM; PHARMACOKINETICS; PLASMA (HUMAN); PLASMAS;

SOLVENT EXTRACTION;

2 PROPANOL; 4 HYDROXYPRAZIQUANTEL; DIAZEPAM; DICHLOROMETHANE; DRUG METABOLITE; HEXANE; PRAZIQUANTEL; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

ANALYTICAL EQUIPMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; ENANTIOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; SINGLE DRUG DOSE; SOLVENT EXTRACTION; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANS ISOMER;

CHROMATOGRAPHY, LIQUID; HUMANS; LINEAR MODELS; PRAZIQUANTEL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

EID: 69749119496     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.07.036     Document Type: Article

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