Early pregnancy loss in celiac women: The role of genetic markers of thrombophilia

Digestive and Liver Disease

Volumn 41, Issue 10, 2009, Pages 717-720

  Ciacci, C ^a   Tortora, R ^a   Scudiero, O ^a,b   Di Fiore, R ^a   Salvatore, F ^a,b,c   Castaldo, G ^a,b,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^c Scuola Europea di Medicina Molecolare SEMM   (Italy)

Author keywords

Abortion; Celiac disease; Pregnancy loss; Thrombophilia

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5 LEIDEN; FIBRINOGEN; FIBRINOGEN B BETA CHAIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTHROMBIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; GENE FREQUENCY; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HUMAN; PREGNANCY OUTCOME; PRIORITY JOURNAL; SPONTANEOUS ABORTION; THROMBOPHILIA;

ABORTION, SPONTANEOUS; ADULT; CASE-CONTROL STUDIES; CELIAC DISEASE; FEMALE; GENETIC MARKERS; GENOTYPE; HUMANS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; THROMBOPHILIA;

EID: 69749118250     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2009.02.050     Document Type: Article

References (25)

1. Green P.H., and Cellier C. Celiac disease. N Engl J Med 357 (2007) 1731-1743
2. Corazza G.R., Frisoni M., Treggiani E.A., et al. Subclinical celiac sprue: increasing occurence and clues to its diagnosis. J Clin Gastroenterol 16 (1993) 16-21
3. Sategna-Guidetti C., Volta U., Ciacci C., et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol 96 (2001) 751-757
4. Lubrano E., Ciacci C., Ames P.R.J., Mazzacca G., Oriente P., and Scarpa R. The artritis of coeliac disease. Prevalence and pattern in 200 adult patients. Br J Rheumatol 35 (1996) 1314-1318
5. Vitoria J.C., Castano L., Rica I., Bilbao J.R., Arrieta A., and Garcia-Masdevall M.D. Association of insulin-dependent diabetes mellitus and celiac disease: a study based on serologic markers. J Pediatr Gastroenterol Nutr 27 (1998) 47-52
6. Ciacci C., Cirillo M., Auriemma G., Di Dato G., Sabbatini F., and Mazzacca G. Celiac disease and pregnancy outcome. Am J Gastroenterol 91 (1996) 718-722
7. Meloni G.F., Dessole S., Vargiu N., Tomasi P.A., and Musumeci S. The prevalence of coelic disease in infertility. Hum Reprod 14 (1999) 2759-2761
8. Faussett M.B., and Branch D.W. Autoimmunity and pregnancy loss. Semin Reprod Med 18 (2000) 379-392
9. Matalon S.T., Blank M., Omoy A., and Shoenfeld Y. The association between anti-thyroid antibodies and pregnancy loss. Am J Reprod Immunol 45 (2001) 72-77
10. Vossen C.Y., Preston F.E., Conard J., et al. Hereditary thrombophilia and fetal loss: a prospective follow-up study. Thromb Haemost 2 (2004) 592-596
11. Kovalevsky G., Gracia C.R., Berlin J.A., Sammel M.D., and Barnhart K.T. Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. Arch Intern Med 164 (2004) 558-563
12. Ridker P.M., Miletich J.P., Buring J.E., et al. Factor V Leiden mutation as a risk factor for recurrent pregnancy loss. Ann Intern Med 128 (1998) 1000-1003
13. Martinelli I., Taioli E., Cetin J., et al. Mutations in coagulation factors in women with unexplained late fetal loss. New Engl J Med 343 (2000) 1015-1018
14. Dossenbach-Glaninger A., van Trotsenburg M., Dossenbach M., et al. Plasminogen activator inhibitor 1 4G/5G polymorphism and coagulation factor XIII Val34Leu polymorphism: impaired fibrinolysis and early pregnancy loss. Clin Chem 49 (2003) 1081-1086
15. Rey E., Kahn S.R., David M., and Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 361 (2003) 901-908
16. Many A., and Kupferminc M.J. Thrombophilias and adverse pregnancy outcome. Haematologica 88 (2003) 729-731
17. Younis J.S., Brenner B., Ohel G., Tal J., Lanir N., and Ben-Ami M. Activated protein C resistence and factor V Leiden mutation can be associated with first-as well as second-trimester recurrent pregnancy loss. Am J Reprod Immunol 43 (2000) 31-35
18. Dilley A., Bonito C., Hooper W.C., et al. Mutations in the factor V, prothrombin and MTHFR genes are not risk factors for recurrent fetal loss. J Matern Fetal Neonatal Med 11 (2002) 176-182
19. Infante-Rivard C., Rivard G.E., Yotov W.V., and Theoret Y. Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. N Engl J Med 347 (2002) 19-25
20. Roque H., Paidas M.J., Funai E.F., Kuczynski E., and Lockwood C.J. Maternal thrombophilias are not associated with early pregnancy loss. Thromb Haemost 91 (2004) 290-295
21. Meroni P.L., Di Simone N., Testoni C., D'Asta M., Acaia B., and Caruso A. Antiphospholipid antibodies as cause of pregnancy loss. Lupus 13 (2004) 649-652
22. Marsh M.N. Gluten, major histocompatibility complex, and the small intestine. Gastroenterology 102 (1992) 330-334
23. Gris J.C., Ripart-Neveu S., Maugard C., et al. Respective evaluation of the prevalence of haemostasis abnormalities in unexplained primary early recurrent miscarriages. The NOHA Study. Thromb Haemost 77 (1997) 1096-1103
24. Camilleri R.S., Peebles D., Portmann C., Everington T., and Cohen H. -455G/A beta-fibrinogen gene polymorphism, factor V Leiden, prothrombin G20210A mutation and MTHFR C677T, and placental vascular complications. Blood Coagul Fibrinolysis 15 (2004) 139-147
25. De La Rochebrochard E., and Thonneau P. Paternal age and maternal age are risk factors for miscarriage: results of a multicentre European study. Hum Reprod 17 (2002) 1649-1656