Increased serum levels of the brain damage marker S100B after apnea in trained breath-hold divers: A study including respiratory and cardiovascular observations

Journal of Applied Physiology

Volumn 107, Issue 3, 2009, Pages 809-815

  Andersson, Johan P A ^a   Linér, Mats H ^a   Jönsson, Henrik ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Glucose; Hemoglobin; Hypoxia; Ionized calcium; Lactate

Indexed keywords

CARBON DIOXIDE; OXYGEN; PROTEIN S100B;

ADULT; APNEA; ARTERIAL GAS; ARTICLE; ASPHYXIA; BLOOD BRAIN BARRIER; BLOOD PRESSURE; BLOOD SAMPLING; BRAIN DAMAGE; BREATH HOLDING; BREATHING; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; DISEASE MARKER; DIVER; DIVING; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERVENTILATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY FUNCTION; SPORT;

ADULT; APNEA; BLOOD GAS ANALYSIS; BLOOD PRESSURE; BRAIN INJURIES; CARBON DIOXIDE; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; DIVING; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERVENTILATION; MALE; NERVE GROWTH FACTORS; OXYGEN CONSUMPTION; RESPIRATORY MECHANICS; S100 PROTEINS; YOUNG ADULT;

EID: 69749096910     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.91434.2008     Document Type: Article

References (51)

1. AIDA. World records. Association Internationale pour le Développement de l'Apnée (International Association for the Development of Apnea). http://www.aida-international.org/ [October 6, 2008].
2. Andersson J, Schagatay E. Effects of lung volume and involuntary breathing movements on the human diving response. Eur J Appl Physiol 77: 19-24, 1998. (Pubitemid 28089996)
3. Bakovic D, Valic Z, Eterovic D, Vukovic I, Obad A, Marinovic-Terzic I, Dujic Z. Spleen volume and blood flow response to repeated breathhold apneas. J Appl Physiol 95: 1460-1466, 2003. (Pubitemid 37169289)
4. Binks AP, Vovk A, Ferrigno M, Banzett RB. The air hunger response of four elite breath-hold divers. Respir Physiol Neurobiol 159: 171-177, 2007. (Pubitemid 47562910)
5. Böttiger BW, Möbes S, Glätzer R, Bauer H, Gries A, Bärtsch P, Motsch J, Martin E. Astroglial protein S-100 is an early and sensitive marker of hypoxic brain damage and outcome after cardiac arrest in humans. Circulation 103: 2694-2698, 2001. (Pubitemid 32538784)
6. Braga CW, Martinez D, Wofchuk S, Portela LV, Souza DO. S100B and NSE serum levels in obstructive sleep apnea syndrome. Sleep Med 7: 431-435, 2006. (Pubitemid 44103489)
7. Dietrich MO, Tort AB, Schaf DV, Farina M, Goncalves CA, Souza DO, Portela LV. Increase in serum S100B protein level after a swimming race. Can J Appl Physiol 28: 710-716, 2003. (Pubitemid 37421464)
8. Donato R. Intracellular and extracellular roles of S100 proteins. Microsc Res Tech 60: 540-551, 2003.
9. Espersen K, Frandsen H, Lorentzen T, Kanstrup IL, Christensen NJ. The human spleen as an erythrocyte reservoir in diving-related interventions. J Appl Physiol 92: 2071-2079, 2002. (Pubitemid 34666436)
10. Fanconi A, Rose GA. The ionized, complexed, and protein-bound fractions of calcium in plasma; an investigation of patients with various diseases which affect calcium metabolism, with an additional study of the role of calcium ions in the prevention of tetany. Q J Med 27: 463-494, 1958.
11. Feiner JR, Bickler PE, Severinghaus JW. Hypoxic ventilatory response predicts the extent of maximal breath-holds in man. Respir Physiol 100: 213-222, 1995.
12. Ferretti G, Costa M, Ferrigno M, Grassi B, Marconi C, Lundgren CEG, Cerretelli P. Alveolar gas composition and exchange during deep breath-hold diving and dry breath holds in elite divers. J Appl Physiol 70: 794-802, 1991.
13. Fitz-Clarke JR. Adverse events in competitive breath-hold diving. Undersea Hyperb Med 33: 55-62, 2006.
14. Gale SD, Hopkins RO. Effects of hypoxia on the brain: neuroimaging and neuropsychological findings following carbon monoxide poisoning and obstructive sleep apnea. J Int Neuropsychol Soc 10: 60-71, 2004.
15. Halter JB, Beard JC, Porte D Jr. Islet function and stress hyperglycemia: plasma glucose and epinephrine interaction. Am J Physiol Endocrinol Metab 247: E47-E52, 1984.
16. Hanin I. The Gulf War, stress and a leaky blood-brain barrier. Nat Med 2: 1307-1308, 1996. (Pubitemid 26401728)
17. Jönsson H, Johnsson P, Birch-Iensen M, Alling C, Westaby S, Blomquist S. S100B as a predictor of size and outcome of stroke after cardiac surgery. Ann Thorac Surg 71: 1433-1437, 2001. (Pubitemid 32452520)
18. Jordan W, Hagedohm J, Wiltfang J, Laier-Groeneveld G, Tumani H, Rodenbeck A, Rüther E, Hajak G. Biochemical markers of cerebrovascular injury in sleep apnoea syndrome. Eur Respir J 20: 158-164, 2002. (Pubitemid 34822938)
19. Journeay WS, Reardon FD, Kenny GP. Cardiovascular responses to apneic facial immersion during altered cardiac filling. J Appl Physiol 94: 2249-2254, 2003.
20. Kapural M, Krizanac-Bengez L, Barnett G, Perl J, Masaryk T, Apollo D, Rasmussen P, Mayberg MR, Janigro D. Serum S-100beta as a possible marker of blood-brain barrier disruption. Brain Res 940: 102-104, 2002. (Pubitemid 34521759)
21. Leuenberger UA, Hardy JC, Herr MD, Gray KS, Sinoway LI. Hypoxia augments apnea-induced peripheral vasoconstriction in humans. J Appl Physiol 90: 1516-1522, 2001.
22. Lin YC, Shida KK, Hong SK. Effects of hypercapnia, hypoxia, and rebreathing on heart rate response during apnea. J Appl Physiol 54: 166-171, 1983.
23. Lindholm P. Loss of motor control and/or loss of consciousness during breath-hold competitions. Int J Sports Med 28: 295-299, 2007. (Pubitemid 46640295)
24. Lindholm P, Lundgren CEG. Alveolar gas composition before and after maximal breath-holds in competitive divers. Undersea Hyperb Med 33: 463-467, 2006.
25. Lindholm P, Nyren S. Studies on inspiratory and expiratory glossopharyngeal breathing in breath-hold divers employing magnetic resonance imaging and spirometry. Eur J Appl Physiol 94: 646-651, 2005. (Pubitemid 41136066)
26. Louis M, Punjabi NM. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers. J Appl Physiol 106: 1538-1544, 2009.
27. Lundgren CEG. The science of breath-hold diving: past, present and future. Breath-Hold Diving. Proceedings of the Undersea and Hyperbaric Medicine/Divers Alert Network 2006 June 20-21 Workshop, edited by Lindholm P, Pollock NW, Lundgren CEG. Durham, NC: Divers Alert Network, 2006, p. 2-15.
28. Macefield G, Burke D. Paraesthesiae and tetany induced by voluntary hyperventilation. Increased excitability of human cutaneous and motor axons. Brain 114: 527-540, 1991.
29. Marchi N, Cavaglia M, Fazio V, Bhudia S, Hallene K, Janigro D. Peripheral markers of blood-brain barrier damage. Clin Chim Acta 342: 1-12, 2004. (Pubitemid 38352910)
30. Moore BW. A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 19: 739-744, 1965.
31. Moosavi SH, Golestanian E, Binks AP, Lansing RW, Brown R, Banzett RB. Hypoxic and hypercapnic drives to breathe generate equivalent levels of air hunger in man. J Appl Physiol 94: 141-154, 2002. (Pubitemid 36014306)
32. Muth CM, Radermacher P, Pittner A, Steinacker J, Schabana R, Hamich S, Paulat K, Calzia E. Arterial blood gases during diving in elite apnea divers. Int J Sports Med 24: 104-107, 2003. (Pubitemid 36403445)
33. Novalija J, Lindholm P, Loring SH, Diaz E, Fox JA, Ferrigno M. Cardiovascular aspects of glossopharyngeal insufflation and exsufflation. Undersea Hyperb Med 34: 415-423, 2007.
34. Otto M, Holthusen S, Bahn E, Söhnchen N, Wiltfang J, Geese R, Fischer A, Reimers CD. Boxing and running lead to a rise in serum levels of S-100B protein. Int J Sports Med 21: 551-555, 2000. (Pubitemid 32002965)
35. 2 on apnea performance in trained breath-hold divers. Eur J Appl Physiol 97: 158-164, 2006.
36. Palada I, Bakovic D, Valic Z, Obad A, Ivancev V, Eterovic D, Shoemaker JK, Dujic Z. Restoration of hemodynamics in apnea struggle phase in association with involuntary breathing movements. Respir Physiol Neurobiol 161: 174-181, 2008. (Pubitemid 351551592)
37. Palada I, Eterovic D, Obad A, Bakovic D, Valic Z, Ivancev V, Lojpur M, Shoemaker JK, Dujic Z. Spleen and cardiovascular function during short apneas in divers. J Appl Physiol 103: 1958-1963, 2007.
38. Perini R, Tironi A, Gheza A, Butti F, Moia C, Ferretti G. Heart rate and blood pressure time courses during prolonged dry apnoea in breathhold divers. Eur J Appl Physiol 104: 1-7, 2008.
39. Potkin R, Cheng V, Siegel R. Effects of glossopharyngeal insufflation on cardiac function: an echocardiographic study in elite breath-hold divers. J Appl Physiol 103: 823-827, 2007. (Pubitemid 47358863)
40. Potkin RT, Uszler JM. Brain function imaging in asymptomatic elite breath-hold divers. In: Breath-Hold Diving. Proceedings of the Undersea and Hyperbaric Medicine/Divers Alert Network 2006 June 20-21 Workshop, edited by Lindholm P, Pollock NW, Lundgren CEG. Durham, NC: Divers Alert Network, 2006, p. 135-136.
41. Richardson M, de Bruijn R, Holmberg HC, Björklund G, Haughey H, Schagatay E. Increase of hemoglobin concentration after maximal apneas in divers, skiers, and untrained humans. Can J Appl Physiol 30: 276-281, 2005. (Pubitemid 40880707)
42. Ridgway L, McFarland K. Apnea diving: long-term neurocognitive sequelae of repeated hypoxemia. Clin Neuropsychol 20: 160-176, 2006.
43. Rosén H, Rosengren L, Herlitz J, Blomstrand C. Increased serum levels of the S-100 protein are associated with hypoxic brain damage after cardiac arrest. Stroke 29: 473-477, 1998. (Pubitemid 28086694)
44. Rothermundt M, Peters M, Prehn JHM, Arolt V. S100B in brain damage and neurodegeneration. Microsc Res Tech 60: 614-632, 2003.
45. Scaccianoce S, Del Bianco P, Pannitteri G, Passarelli F. Relationship between stress and circulating levels of S100B protein. Brain Res 1004: 208-211, 2004. (Pubitemid 38368078)
46. Schagatay E, Andersson JPA, Hallén M, Pålsson B. Selected contribution: role of spleen emptying in prolonging apneas in humans. J Appl Physiol 90: 1623-1629, 2001. (Pubitemid 32220954)
47. Schagatay E, Andersson JPA, Nielsen B. Hematological response and diving response during apnea and apnea with face immersion. Eur J Appl Physiol 101: 125-132, 2007. (Pubitemid 47323293)
48. Schagatay E, Haughey H, Reimers J. Speed of spleen volume changes evoked by serial apneas. Eur J Appl Physiol 93: 447-452, 2005. (Pubitemid 40074305)
49. 2+ in bloodstream and brain. Can J Physiol Pharmacol 65: 1078-1085, 1987.
50. Stålnacke BM, Ohlsson A, Tegner Y, Sojka P. Serum concentrations of two biochemical markers of brain tissue damage S-100B and neurone specific enolase are increased in elite female soccer players after a competitive game. Br J Sports Med 40: 313-316, 2006.
51. Watson P, Shirreffs SM, Maughan RJ. Blood-brain barrier integrity may be threatened by exercise in a warm environment. Am J Physiol Regul Integr Comp Physiol 288: R1689-R1694, 2005. (Pubitemid 40720719)