Evaluation of treatment with cysteamine eyedrops for cystinosis with confocal microscopy

Cornea

Volumn 28, Issue 8, 2009, Pages 938-940

  Tavares, Rui ^a   Coelho, Dalila ^a   Macário, Maria Carmo ^a   Torres, Alexandra ^a   Quadrado, Maria João ^a   Murta, Joaquim ^a  

^a CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

Author keywords

Confocal microscopy; Cysteamine eyedrops; Cystinosis

Indexed keywords

CYSTINE; MERCAPTAMINE;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BASAL CELL; BLEPHAROSPASM; CASE REPORT; CONFOCAL MICROSCOPY; CORNEA DISEASE; CORNEA EPITHELIUM; CORNEA STROMA; CRYSTAL; CRYSTAL STRUCTURE; CYSTINOSIS; DENSITY; DRUG EFFICACY; FEMALE; HUMAN; PATIENT COMPLIANCE; PHOTOPHOBIA; PRIORITY JOURNAL; SLIT LAMP; TREATMENT DURATION; TREATMENT OUTCOME; VISUAL ACUITY;

CORNEAL DISEASES; CRYSTALLIZATION; CRYSTALLOGRAPHY; CYSTEAMINE; CYSTINE; CYSTINOSIS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MEDICAL RECORDS; MICROSCOPY, CONFOCAL; OPHTHALMIC SOLUTIONS; PHOTOPHOBIA; TREATMENT OUTCOME; VISUAL ACUITY; YOUNG ADULT;

EID: 69749090041     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICO.0b013e318199eb5b     Document Type: Article

References (14)

1. Sutphin JE. Basic and Clinical Science Course, Section 8. 2005-2006, External Disease and Cornea, San Francisco: American Academy of Ophthalmology; 2004.
2. Gahl WA, Thoene JG, Schneider JA. Cystinosis: a disorder of lysosomal membrane transport. In: Scriver CR, Beaudet AL, Sly WS, et al, eds. The Metabolic & Molecular Bases of Inherited Disease, 8th ed, vol III. New York: McGraw Hill; 2001:5085-5108.
3. Victor G, Campos PJG, Alves MR, et al. Microscopia confocal in vivo na cistinose - Relato de caso. Arq Brá s Oftalmol. 2004;67:553-557.
4. Iwata F, Kuel EM, Reed GF, et al. A randomized clinical trial of topical cysteamine disulfide (cystamine) versus free thiol (cysteamine) in the treatment of corneal cystine crystals in cystinosis. Mol Genet Metab. 2000;71:100-120. (Pubitemid 28460221)
5. Tsilou ET, Rubin BI, Reed GF, et al. Age-related prevalence of anterior segment complications in patients with infantile nephropathic cystinosis. Cornea. 2002;21:173-176.
6. Gahl WA, Thoene JG, Schneider JA. Cystinosis: a disorder of lysosomal membrane transport. In: Scriver CR, Beaudet AL, Sly WS, et al, eds. The Metabolic & Molecular Bases of Inherited Disease, 8th ed, vol III. New York: McGraw Hill; 2001:5094-5097.
7. Pisoni RL, Thoene JG, Christensen HN. Detection and characterization of carrier-mediated cationic amino acid transport in lysosomes of normal and cystinotic human fibroblasts. J Biol Chem. 1985;260:4791.
8. Gahl WA, Kuehl EM, Iwata F, et al. Corneal crystals in nephropathic cystinosis: natural history and treatment with cysteamine eyedrops. Mol Genet Metab. 2000;71:100-120. (Pubitemid 30749533)
9. Tsilou ET, Thompson D, Lindblad AS, et al. A multicentre randomised double masked clinical trial of a new formulation of topical cysteamine for the treatment of corneal cystine crystals in cystinosis. Br J Ophthalmol. 2003;87:28-31. (Pubitemid 36071774)
10. De Nicola R, Labbé A, Amar N, et al. Microscopie confocale et pathologies de la surface oculaire: corrélations anatomo-cliniques. J Fr Ophtalmol. 2005;28:691-698. (Pubitemid 41480582)
11. Leduc C, Dupas B, Ott-Benoist AC, et al. Intérêt du microscope confocal cornéen in vivo HRT2 pour l'étude de l'epithélium cornéo-conjonctival. J Fr Ophthalmol. 2004;27978-27986
12. Ficher-Tartaglia D, Kahni-Simonius J. Gotas oftálmicas de cloridrato de cisteamina - elaboracxão, análise e estabilidade. Kranzenhauspharmazie. 1994;15:10.
13. Kaiser-Kupfer MI, Fujikawa L, Kuwabara T, et al. Removal of corneal crystals by topical cysteamine in nephropathic cystinosis. N Engl J Med. 1987;316:775-779. (Pubitemid 17046086)
14. Kahn AO, Latimer B. Successful use of topical cysteamine formulated from the oral preparation in a child with keratopathy secondary to cystinosis. Am J Ophthalmol. 2004;138:674-675. (Pubitemid 39420511)