Anti-gastritic effects of magnolol and honokiol from the stem bark of magnolia obovata

Biomolecules and Therapeutics

Volumn 16, Issue 3, 2008, Pages 270-276

  Cho, So Yean ^a   Lee, Je Hyuk ^a   Bae, Ki Hwan ^b   Kim, Yeong Shik ^c   Jeong, Choon Sik ^a  

^a Duksung Women's University   (South Korea)

^b Chungnam National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Gastritis; Helicobacter pylori; Honokiol; Magnolia Bark (MB); Magnolol

Indexed keywords

CIMETIDINE; HONOKIOL; HYDROTALCITE; MAGNOLIA EXTRACT; MAGNOLOL; SUCRALFATE; SYRINGIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BARK; CANCER CELL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; GASTRITIS; GROWTH INHIBITION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IC 50; MAGNOLIACEAE; MALE; NONHUMAN; PLANT STEM; PYLORUS; RAT; STOMACH ACID SECRETION; STOMACH CANCER; STOMACH MUCUS; STOMACH PH; STOMACH SECRETION;

HELICOBACTER PYLORI; MAGNOLIA; MAGNOLIA OBOVATA; RATTUS;

EID: 69749086461     PISSN: 19769148     EISSN: None     Source Type: Journal    
DOI: 10.4062/biomolther.2008.16.3.270     Document Type: Article

References (28)

1. Bae, E.A., Han M.J. and Kim, D.H. (1999) In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites. Planta Med. 65, 442-443. (Pubitemid 29299836)
2. Chang, C.P., Hsu, Y.C. and Lin, M.T. (2003) Magnolol protects against cerebral ischaemic injury of rat heatstroke. Clin. Exp. Pharmacol. Physiol. 376, 387-392. (Pubitemid 36713997)
3. Gerrits, M.M., van Vliet, A.H.M., Kuipers, E.J. and Kusters, J.G. (2006) Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications. Lancet Infect. Dis. 6, 699-709. (Pubitemid 44601991)
4. Gyires, K. (2005) Gastric mucosal protection: from prostaglandins to gene-therapy. Curr. Med. Chem. 12, 203-215. (Pubitemid 40089834)
5. Ikeda, K., Sakai, Y. and Nagase, H. (2003) Inhibitory effect of magnolol on tumor metastasis in mice. Phytother. Res. 17, 933-937. (Pubitemid 37152762)
6. Kim, Y.S., Jung, D.H., Kim, N.H., Lee, Y.M. and Kim, J.S. (2007) Effect of magnolol on TGF-β1 and fibronectin expression in human retinal pigment epithelial cells under diabetic conditions. Eur. J. Pharmacol. 562, 12-19. (Pubitemid 46466755)
7. Kinoshita, M., Noto, T. and Tamaki, H. (1995) Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric lesions and gastric mucosal resistance to ulcerogenic agents in rats. Biol. Pharm. Bull. 18, 223-226.
8. Kitagawa, H., Takeda, F. and Kohei, H. (1986) A simple method for estimation of gastric mucus and effects of antiulcerogenic agents on the decrease in mucus during water-immersion stress in rats. Arzneimittelforschung 36, 1240-1244. (Pubitemid 16035241)
9. Kusters, J.G., van Vliet, A.H. and Kuipers, E.J. (2006) Pathogenesis of Helicobacter pylori infection. Clin. Microbiol. Rev. 19, 449-490.
10. La Casa, C., Villegas, I., Alarcón de la Lastra, C., Motilva, V. and Martín Calero, M.J. (2000) Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J. Ethnopharmacol. 71, 45-53.
11. Lo, Y.C., Teng, C.M., Chen, C.F., Chen, C.C. and Hong, C.Y. (1994) Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem. Pharmacol. 47, 549-553.
12. Matysiak-Budnik, T. and Megraud, F. (2006) Helicobacter pylori infection and gastric cancer. Eur. J. Cancer 42, 708-716.
13. McQuaid, K.R. and Isenberg, J.I. (1992) Medical therapy of peptic ulcer disease. Surg. Clin. North Am. 72, 285-316.
14. Mizui, T. and Dodeuchi, M. (1983) Effect of polyamines on acidified ethanol-induced gastric lesion in rats. Jpn. J. Pharmacol. 33, 939-945.
15. Nakazawa, T., Yasuda, T. and Ohsawa, T. (2003) Metabolites of orally administrated Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice. J. Pharmacol. 55, 1583-1591. (Pubitemid 37441366)
16. Neugut, A.I., Hayek, M. and Howe, G. (1996) Epidemiology of gastric cancer. Semin. Oncol. 3, 281-291. (Pubitemid 26187728)
17. Nostro, A., Cellini, L., Di Bartolomeo, S., Di Campli, E., Grande, R., Cannatelli, M. A., Marzio, L. and Alonzo, V. (2005) Antibacterial effect of plant extracts against Helicobacter pylori. Phytother. Res. 19, 198-202. (Pubitemid 40827641)
18. Pisegna, J. R. (2002) Pharmacology of acid suppression in the hospital setting: focus on proton pump inhibition. Crit. Care Med. 30, S356-S361.
19. Pyo, M.K., Lee, Y. and Yun-Choi, H.S. (2002) Anti-platelet effect of the constituents isolated from the bark and fruits of Magnolia ovata. Arch. Pharm. Res. 25, 325-328. (Pubitemid 43093313)
20. Seiki, M., Ukei, S., Tanaka, Y. and Soeda, M. (1990) Studies of anti-ulcer effects of a new compound, zinc L-carnosine (Z-103). Nippon Yakurigaku Zasshi 95, 257-269.
21. Shay, H., Komarov, S.A., Fels, S.S. and Meranze, D. (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol. 4, 43-61.
22. Shoji, Y., Takashi, N., Akihide, K., Toshihiro, N. and Itsuo, N. (1991) Isolation and characterization of phenolic compounds from Magnoliae Cortex produced in China. Chem. Pharm. Bull. 39, 2024-2036.
23. Tanaka, K., Hasegawa, J., Asamitsu, K. and Okamoto, T. (2007) Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor βB. Eur. J. Pharmacol. 565, 212-219. (Pubitemid 46782762)
24. Tarnawski, A., Tanoue, K., Santos, A.M. and Sarfeh, I.J. (1995) Cellular and molecular mechanisms of gastric ulcer healings. Scand. J. Gastroenterol. Suppl. 210, 9-14. (Pubitemid 26001725)
25. Valerie, S., Hartmut, F., Ulrich, P. and Rodney, S. (2001) Coniferyl alcohol metabolism in conifers - I. Glucosidic turnover of cinnamyl aldehydes by UDPG: coniferyl alcohol glucosyltransferase from pine cambium. Phytochemistry 64, 1401-1404.
26. van de Loosdrecht, A.A., Nennie, E., Ossenkoppele, G.J., Beelen, R.H. and Langenhuijsen, M.M. (1991) Cell mediated cytotoxicity against U937 cells by human monocytes and macrophages in a modified colorimetric MTT assay. A methodological study. J. Immunol. Method. 141, 15-22.
27. Welage, L.S. (2003) Pharmacologic properties of proton pump inhibitors. Pharmacotherapy 23, 74S-80S.
28. Woo, T.W., Chang, M.S., Chung, Y.K., Kim, K.B., Sohn, S.K., Kim, S.G. and Choi, W.S. (1998) Inhibitory action of YJA20379, a new proton pump inhibitor on Helicobacter pylori growth and urease. Arch. Pharm. Res. 21, 6-11.