Direct inhibition of ERK1/2 phosphorylation as a possible mechanism for the antiproliferative action of 3,4-diOH-PCB3 in the MCF-7 cell line

Toxicology Letters

Volumn 190, Issue 2, 2009, Pages 187-192

  Ptak, Anna ^a   Gut, Patrycja ^a   Błachuta, Małgorzata ^a   Rak, Agnieszka ^a   Gregoraszczuk, Ewa Ł ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

cAMP PKA; ERK1 2; Hydroxylated metabolites; PCB3; Proliferation; SHBG

Indexed keywords

3',4' DIHYDROXY 4 MONOCHLOROBIPHENYL; 4 MONOCHLOROBIPHENYL; 4' HYDROXY 4 MONOCHLOROBIPHENYL; BROXURIDINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MEMBRANE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; POLYCHLORINATED BIPHENYL; SEX HORMONE BINDING GLOBULIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; EXPOSURE; HUMAN; HUMAN CELL; INHIBITION KINETICS; METABOLITE; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANTINEOPLASTIC AGENTS; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; POLYCHLORINATED BIPHENYLS; SECOND MESSENGER SYSTEMS; SEX HORMONE-BINDING GLOBULIN; SIGNAL TRANSDUCTION;

EID: 69649092024     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.07.013     Document Type: Article

References (33)

1. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., and Saltiel A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270 (1995) 27489-27494
2. Bulayeva N.N., and Watson C.S. Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways. Environ. Health Perspect. 112 (2004) 1481-1487
3. Déchaud H., Ravard C., Claustrat F., de la Perrière A.B., and Pugeat M. Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG). Steroids 64 (1999) 328-334
4. Falkenstein E., Tillmann H.C., Christ M., Feuring M., and Wehling M. Multiple actions of steroid hormones-a focus on rapid, nongenomic effects. Pharmacol. Rev. 52 (2000) 513-556
5. Filardo E., and Thomas J.P. GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. Trends Endocrinol. Metab. 16 (2005) 362-367
6. Fortunati N., Fissore F., Fazzari A., Berta L., Benedusi-Pagliano E., and Frairia R. Biological relevance of the interaction between sex steroid binding protein and its specific receptor of MCF-7 cells: effect on the estradiol-induced cell proliferation. J. Steroid Biochem. Mol. Biol. 45 (1993) 435-444
7. Fortunati N., Fissore F., Fazzari A., Becchis M., Comba A., Catalano M.G., Berta L., and Frairia R. Sex steroid binding protein exerts a negative control on estradiol action in MCF-7 cells (human breast cancer) through cyclic adenosine 3′,5′-monophosphate and protein kinase A. Endocrinology 137 (1996) 686-692
8. Fortunati N., Fissore F., Fazzari A., Piovano F., Catalano M.G., Becchis M., Berta L., and Frairia R. Estradiol induction of cAMP in breast cancer cells is mediated by foetal calf serum (FCS) and sex hormone-binding globulin (SHBG). J. Steroid Biochem. Mol. Biol. 70 (1999) 73-80
9. Gregoraszczuk E.L., Rak A., Ludewig G., and Gasińska A. Effects of estradiol, PCB3, and their hydroxylated metabolites on proliferation, cell cycle, and apoptosis of human breast cancer cells. Environ. Toxicol. Pharmacol. 25 (2008) 227-233
10. Houslay M.D., and Kolch W. Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling. Mol. Pharmacol. 58 (2000) 659-668
11. Hryb D.J., Khan M.S., Romas N.A., and Rosner W. The control of the interaction of sex hormone-binding globulin with its receptor by steroid hormones. J. Biol. Chem. 15 (1990) 6048-6054
12. Jury H.H., Zacharewski T.R., and Hammond G.L. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J. Steroid Biochem. Mol. Biol. 75 (2000) 167-176
13. Lee I.R., Dawson S.A., Wetherall J.D., and Hahnel R. Sex hormone-binding globulin secretion by human hepatocarcinoma cells is increased by both estrogens and androgens. Clin. Endocrinol. Metab. 64 (1987) 825-831
14. Loukovaara M., Carson M., and Adlercreutz H. Regulation of production and secretion of sex hormone-binding globulin in HepG2 cell cultures by hormones and growth factors. J. Clin. Endocrinol. Metab. 80 (1995) 160-164
15. Lowe W.L., Fu R., and Banko M. Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3′,5′-monophosphate in MCF-7 breast cancer cells. Endocrinology 138 (1997) 2219-2226
16. Martin M.E., Vranckx R., Benassayag C., and Nunez E.A. Modifications of the properties of human sex steroid-binding protein by nonesterified fatty acids. J. Biol. Chem. 261 (1986) 2954-2959
17. Martin M.E., Haourigui M., Pelissero C., Benassayag C., and Nunez E.A. Interactions between phytoestrogens and human sex steroid binding protein. Life Sci. 58 (1996) 429-436
18. Migliaccio A., Di Domenico M., Castoria G., de Falco A., Bontempo P., Nola E., and Auricchio F. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J. 15 (1996) 1292-1300
19. Norman A.W., Mizwicki M.T., and Norman D.P. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat. Rev. Drug Discov. 3 (2004) 27-41
20. Odlind V., Elamsson K., Englund D.E., Victor A., and Johansson E.D. Effects of oestradiol on sex hormone binding globulin. Acta Endocrinol. (Copenh.) 101 (1982) 248-253
21. Porto C.S., Musto N.A., Bardin C.W., and Gunsalus G.L. Binding of an extracellular steroid-binding globulin to membranes and soluble receptors from human breast cancer cells (MCF-7 cells). Endocrinology 130 (1992) 2931-2936
22. Ptak A., Ludewig G., Lehmler H.J., Wójtowicz A.K., Robertson L.W., and Gregoraszczuk E.L. Comparison of the actions of 4-chlorobiphenyl and its hydroxylated metabolites on estradiol secretion by ovarian follicles in primary cells in culture. Reprod. Toxicol. 20 (2005) 57-64
23. Ptak A., Ludewig G., and Gregoraszczuk E.Ł. A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary. J. Physiol. Pharmacol. 59 (2008) 577-588
24. Ptak, A., Ludewig, G., Rak, A., Nadolna, W., Bochenek, M., Gregoraszczuk, E., 2009. Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis. Environ. Int., doi:10.1016/j.envint.2009.06.012
25. Pugeat M.M., Dunn J.F., and Nisula B.C. Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J. Clin. Endocrinol. Metab. 53 (1981) 69-75
26. Radice S., Chiesara E., Fucile S., and Marabini L. Different effects of PCB101, PCB118, PCB138 and PCB153 alone or mixed in MCF-7 breast cancer cells. Food Chem. Toxicol. 46 (2008) 2561-2567
27. Ramamoorthy K., Gupta M.S., Sun G., McDougal A., and Safe S.H. 3,3′4,4′-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells. Carcinogenesis 20 (1999) 115-123
28. Revelli A., Massobrio M., and Tesarik J. Nongenomic actions of steroid hormones in reproductive tissues. Endocr. Rev. 19 (1998) 13-17
29. Ropero A.B., Alonso-Magdalena P., Ripoll C., Fuentes E., and Nadal A. Rapid endocrine disruption: environmental estrogen actions triggered outside the nucleus. J. Steroid Biochem. Mol. Biol. 102 (2006) 163-169
30. Stork P.J., and Schmitt J.M. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol. 12 (2002) 258-266
31. Thomas P., and Dong J. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. J. Steroid Biochem. Mol. Biol. 102 (2006) 175-179
32. Watson C.S., Bulayeva N.N., Wozniak A.L., and Alyea R.A. Xenoestrogens are potent activators of nongenomic estrogenic responses. Steroids 72 (2007) 124-134
33. Zivadinovic D., Gametchu B., and Watson C.S. Membrane estrogen receptor-alpha levels In MCF-7 breast cancer cells predict cAMP and proliferation responses. Breast Cancer Res. 7 (2005) 101-112