Autologous T cell depleted haematopoietic stem cell transplantation in children with severe juvenile idiopathic arthritis in the UK (2000-2007)

Molecular Immunology

Volumn 47, Issue 1, 2009, Pages 46-51

  Abinun, Mario ^a   Flood, Terence J ^a   Cant, Andrew J ^a   Veys, Paul ^b   Gennery, Andrew R ^c   Foster, Helen E ^c   Friswell, Mark ^a   Baildam, Eileen ^d   Davidson, Joyce ^e   Southwood, Taunton R ^f   Livermore, Polly ^g   Wedderburn, Lucy R ^g  

^a NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d ALDER HEY CHILDREN S HOSPITAL   (United Kingdom)

^e ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^f UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Autologous haematopoietic stem cell transplantation; Juvenile idiopathic arthritis; T cell depletion

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; ATLIZUMAB; CIDOFOVIR; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FLUDARABINE; FOSCARNET; GANCICLOVIR; IMMUNOGLOBULIN; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6 RECEPTOR INHIBITOR; LEFLUNOMIDE; METHOTREXATE; METHYLPREDNISOLONE; PREDNISOLONE; RITUXIMAB; THYMOCYTE ANTIBODY; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG;

ADENOVIRUS; ADENOVIRUS INFECTION; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; CHILD; CYTOMEGALOVIRUS INFECTION; DIARRHEA; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG FEVER; DRUG MEGADOSE; DRUG RESPONSE; DYSPNEA; HEMOPHAGOCYTIC SYNDROME; HUMAN; HYPOXIA; IMMUNE DEFICIENCY; IMMUNOMODULATION; INFECTION RISK; INFLAMMATION; JUVENILE RHEUMATOID ARTHRITIS; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; QUALITY OF LIFE; RELAPSE; REMISSION; REVIEW; SINGLE DRUG DOSE; T CELL DEPLETION; TACHYCARDIA; TREATMENT RESPONSE; UNITED KINGDOM; VIREMIA; VIRUS REACTIVATION;

ADOLESCENT; ARTHRITIS, JUVENILE RHEUMATOID; CHILD; FEMALE; FOLLOW-UP STUDIES; GREAT BRITAIN; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSION; LYMPHOCYTE DEPLETION; MALE; PATIENT SELECTION; RISK ASSESSMENT; TIME FACTORS; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME; VIRUS ACTIVATION;

ADENOVIRIDAE; CYTOMEGALOVIRUS;

EID: 69549155771     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.12.029     Document Type: Review

References (31)

1. Barron K.S., Wallace C., Woolfrey A., Laxer R.M., Hirsch R., Horwitz M., Siegel J., Filipovich L., Wulffraat N., Passo M., and Rider L.G. Autologous stem cell transplantation for pediatric rheumatic diseases. NIH Workshop Report. J. Rheumatol. 28 (2001) 2337-2358
2. Brinkman D.M.C., de Kleer I.M., ten Cate R., van Rossum M.A.J., Bekkering W.P., Fasth A., van Tol M.J.D., Kuis W., Wulffraat N.M., and Vossen J.M. Autologous stem cell transplantation in children with severe progressive systemic or polyarticular juvenile idiopathic arthritis. Long-term follow up of a prospective clinical trial. Arthritis Rheum. 56 (2007) 2410-2421
3. De Kleer I.M., Brinkman D.M.C., Ferster A., Abinun M., Quartier P., van der Net J., ten Cate R., Wedderburn L.R., Horneff G., Oppermann J., Zintl F., Foster H.E., Prieur A.M., Fasth A., van Rossum M.A.J., Kuis W., and Wulffraat N.M. Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity. Ann. Rheum. Dis. 63 (2004) 1318-1326
4. De Kleer I., Vastert B., Klein M., Teklenburg G., Arkesteijn G., Yung G.P., Albani S., Kuis W., Wulffraat N., and Prakken B. Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4CD25 immune regulatory network. Blood 107 (2006) 1696-1702
5. Donn R., Ellison S., Lamb R., Day T., Baildam E., and Ramanan A.V. Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 58 (2008) 869-874
6. Ferreira R.A., Vastert S.J., Abinun M., Foster H.E., Modesto C., Olivé T., Kuis W., and Wulffraat N.M. Hemophagocytosis during fludarabine-based SCT for systemic juvenile idiopathic arthritis. Bone Marrow Transplant. 38 (2006) 249-251
7. Foster, H.E., Davidson, J., Baildam, E., Abinun, M., Wedderburn, L.R., 2006. Autologous haematopoietic stem cell rescue for severe rheumatic disease in children. Rheumatology 45, 1570-1571. Guidance for BSPAR members. http://rheumatology.oxfordjournals.org/cgi/data/kel319a/DC1/1.
8. Gea-Banacloche J.C., and Weinberg G.A. Monoclonal antibody therapeutics and risk for infection. Pediatr. Infect. Dis. J. 26 (2007) 1049-1052
9. Griffith, L.M., Pavletic, S.Z., Tyndall, A., Bredeson, C.N., Bowen, J.D., Childs, R.W., Gratwohl, A., van Laar, J.M., Mayes, M.D., Martin, R., McSweeney, P.A., Muraro, P.A., Openshaw, H., Saccardi, R., Sandmaier, B.M., Forman, S.J., Nash, R.A., Workshop participants, 2005. Feasibility of allogeneic hematopoietic stem cell transplantation for autoimmune disease: position statement from a National Institute of Allergy and Infectious Diseases and National Cancer Institute-Sponsored International Workshop, Bethesda, MD, March 12 and 13, 2005. Biol. Blood Marrow Transplant. 11, 862-870.
10. Hazen M.M., Woodward A.L., Hofmann I., Degar B.A., Grom A., Filipovich A.H., and Binstadt B.A. Mutations of the hemophagocytic lymphohistiocytosis-associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis. Arthritis Rheum. 58 (2008) 567-570
11. Ilowite N.T. Update on biologics in juvenile idiopathic arthritis. Curr. Opin. Rheumatol. 20 (2008) 613-618
12. Kuis W., Wulffraat N.M., and Petty R.E. Autologous stem cell transplantation: an alternative for refractory juvenile chronic arthritis. Rheumatology 38 (1999) 737-738
13. Laxer R.M., and Harrison C. Bioethical issues in autologous stem cell transplantation in children and adults with arthritis. J. Rheumatol. 28 (2001) 2147-2150
14. Lovell D.J., Reiff A., Ilowite N.T., Wallace C.A., Chon Y., Lin S.L., Baumgartner S.W., Giannini E.H., and Pediatric Rheumatology Collaborative Study Group. Safety and efficacy of up to eight years of continuous etanercept therapy in patients with juvenile rheumatoid arthritis. Arthritis Rheum. 58 (2008) 1496-1504
15. Marmont A.M. Allogeneic haematopoietic stem cell transplantation for severe autoimmune diseases: great expectations but controversial evidence. Bone Marrow Transplant. 38 (2006) 1-4
16. Myers A., Clark J., and Foster H. Tuberculosis and treatment with infliximab. N. Engl. J. Med. 346 (2002) 623-626
17. Pavletic S.Z. Nonmyeloablative allogeneic hematopoietic stem cell transplantation for autoimmune disease. Arthritis Rheum. 50 (2004) 2387-2390
18. Quartier P., Prieur A.M., and Fischer A. Haemopoietic stem cell transplantation for juvenile chronic arthritis. Lancet 353 (1999) 1885-1886
19. Ravelli A., and Martini A. Juvenile idiopathic arthritis. Lancet 369 (2007) 767-778
20. Roord S.T.A., de Jager W., Boon L., Wulffraat N., Martens A., Prakken B., and van Wijk F. Autologous bone marrow transplantation in autoimmune arthritis restores immune homeostasis through CD4CD25Foxp3 regulatory T cells. Blood 111 (2008) 5233-5241
21. Sykes M., and Nikolic B. Treatment of severe autoimmune disease by stem cell transplantation. Nature 435 (2005) 620-627
22. Takken T., van den Beuken C., Wullfraat N.C., Helders P.J.M., and van der Net J. Exercise tolerance in children with juvenile idiopathic arthritis after autologous SCT. Bone Marrow Transplant. (2008) 10.1038/bmt.2008.171
23. Ten Kate R., Brinkman D.M., van Rossum M.A., Lankester A.C., Bredius R.G., Egeler M.R., van Tol M.J.D., and Vossen J.M. Macrophage activation syndrome after autologous stem cell transplantation for systemic juvenile idiopathic arthritis. Eur. J. Pediatr. 161 (2002) 685-686
24. Vieger A.M., Brinkman D., Quartier P., Prieur A.M., ten Cate R., Berings M., and Wulffraat N.M. Infection associated MAS in 3 patients receiving ASCT for refractory juvenile chronic arthritis. Bone Marrow Transplant. 25 Suppl. 1 (2000) 81
25. Wedderburn L.R., Abinun M., Palmer P., and Foster H.E. Autologous haematopietic stem cell transplantation in juvenile idiopathic arthritis. Arch. Dis. Child. 88 (2003) 201-205
26. Wulffraat N.M., and Kuis W. Treatment of refractory juvenile idiopathic arthritis. J. Rheumatol. 28 (2001) 929-931
27. Wulffraat N., van Royen A., Bierings M., Vossen J., and Kuis W. Autologous haemopietic stem cell transplantation in four patients with refractory juvenile chronic arthritis. Lancet 353 (1999) 550-553
28. Wulffraat N.M., Kuis W., and Petty R. Proposed guidelines for autologous stem cell transplantation in juvenile chronic arthritis (Addendum). Pediatric Rheumatology Workshop. Rheumatology (Oxford) 38 (1999) 777-778
29. Wulffraat N.M., BrinkmanD, Ferster A., Opperman J., ten Cate R., Weddreburn L., Foster H., Abinun M., Prieur A.M., Horneff G., Zintl F., de Kleer I., and Kuis W. Long-term follow-up of autologous stem cell transplantation for refractory juvenile idiopathic arthritis. Bone Marrow Transplant. 32 (2003) s61-s64
30. Wulffraat N.M., Vastert B., and Tyndall A. Treatment of refractory autoimmune diseases with autologous stem cell transplantation: focus on juvenile idiopathic arthritis. Bone Marrow Transplant. 35 (2005) s27-s29
31. Zhang K., Biroschak J., Glass D.N., Thompson S.D., Finkel T., Passo M.H., Binstadt B.A., Filipovich A., and Grom A.A. Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms. Arthritis Rheum. 58 (2008) 2892-2896