Review of Adjuvant Radiochemotherapy for Resected Pancreatic Cancer and Results From Mayo Clinic for the 5th JUCTS Symposium

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 2, 2009, Pages 364-368

  Miller, Robert C ^a   Iott, Matthew J ^a   Corsini, Michele M ^a  

^a MAYO CLINIC   (United States)

Author keywords

Adjuvant; Carcinoma; Pancreas; Radiotherapy

Indexed keywords

5-FLUOROURACIL; ADJUVANT; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ADJUVANT TREATMENT; CARCINOMA; CLINICAL TRIAL; HISTOLOGIC GRADE; INTRAOPERATIVE RADIOTHERAPY; LITERATURE REVIEWS; MULTI VARIATE ANALYSIS; OVERALL SURVIVAL; PANCREAS; PANCREATIC CANCERS; POSITIVE LYMPH NODES; POSITIVE SURGICAL MARGIN; PROGNOSTIC FACTORS; RADIOCHEMOTHERAPY; UNIVARIATE; UNIVARIATE ANALYSIS;

CHEMOTHERAPY; DECISION MAKING; MULTIVARIANT ANALYSIS; RISK ANALYSIS; TRANSPLANTATION (SURGICAL); TUMORS;

RADIOTHERAPY;

FLUOROURACIL;

ARTICLE; CANCER ADJUVANT THERAPY; CANCER RADIOCHEMOTHERAPY; CANCER SURGERY; CLINICAL TRIAL; FOLLOW UP; HUMAN; LYMPH NODE METASTASIS; OVERALL SURVIVAL; PANCREAS CANCER; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE FRACTIONATION; RISK FACTOR; TREATMENT OUTCOME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTINEOPLASTIC AGENTS; CHEMOTHERAPY, ADJUVANT; CLINICAL TRIALS, PHASE III AS TOPIC; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; MINNESOTA; PANCREATIC NEOPLASMS; PROGNOSIS; RADIATION ONCOLOGY; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES;

EID: 69549138196     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.11.069     Document Type: Article

References (15)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2008. CA Cancer J Clin 58 (2008) 71-96
2. Lim J., Chien M., and Earle C. Prognostic factors following curative resection for pancreatic adenocarcinoma: A population-based, linked database analysis of 396 patients. Ann Surg 237 (2003) 74-85
3. Trede M., Schwall G., and Saeger H. Survival after pancreatoduodenectomy: 118 consecutive resections without an operative mortality. Ann Surg 211 (1990) 447-458
4. Geer R., and Brennan M. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Ann Surg 165 (1993) 68-72
5. Crist D., Sitzmann J., and Cameron J. Improved hospital morbidity, mortality, and survival after the Whipple procedure. Ann Surg 206 (1988) 358-365
6. Kalser M.H., and Ellenberg S.S. Pancreatic cancer: Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120 (1985) 899-903
7. Klinkenbijl J.H., Jeekel J., Sahmoud T., et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: Phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 230 (1999) 776-782 discussion 782-774
8. Neoptolemos J.P., Dunn J.A., Stocken D.D., et al. Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: A randomised controlled trial. Lancet 358 (2001) 1576-1585
9. Neoptolemos J.P., Stocken D.D., Friess H., et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350 (2004) 1200-1210
10. Corsini M.M., Miller R.C., Haddock M.G., et al. Adjuvant radiotherapy and chemotherapy for pancreatic carcinoma: The Mayo Clinic experience (1975-2005). J Clin Oncol 26 (2008) 3511-3516
11. Gunderson L., Martenson J., Smalley S., et al. Upper gastrointestinal cancers: Rationale, results, and techniques of treatment. Front Radiat Ther Oncol 28 (1994) 121-139
12. Gastrointestinal Tumor Study Group. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 59 (1987) 2006-2010
13. Garofalo M.C., Regine W.F., and Tan M.T. On statistical reanalysis, the EORTC trial is a positive trial for adjuvant chemoradiation in pancreatic cancer. Ann Surg 244 (2006) 332-333 author reply 333
14. Regine W.F., Winter K.A., Abrams R.A., et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: A randomized controlled trial. JAMA 299 (2008) 1019-1026
15. Oettle H., Post S., Neuhaus P., et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial. JAMA 297 (2007) 267-277