Nanoscale aggregation of cellular β2-adrenergic receptors measured by plasmonic interactions of functionalized nanoparticles

ACS Nano

Volumn 3, Issue 8, 2009, Pages 2329-2339

  Kennedy, David C ^a   Tay, Li Lin ^a   Lyn, Rodney K ^a   Rouleau, Yanouchka ^a   Hulse, John ^a   Pezacki, John Paul ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Aggregation; Cell receptors; Multimodal imaging; Plasmonic nanoparticles; Surface enhanced Raman scattering

Indexed keywords

AGGREGATION; CELL RECEPTORS; MULTIMODAL IMAGING; PLASMONIC NANOPARTICLES; SURFACE-ENHANCED RAMAN SCATTERING;

AGGLOMERATION; ENZYME INHIBITION; HIGH RESOLUTION ELECTRON MICROSCOPY; LABELS; MAMMALS; NANOPARTICLES; NANOSTRUCTURED MATERIALS; PLASMONS; RAMAN SCATTERING; SCANNING; SCANNING ELECTRON MICROSCOPY; SCATTERING; SIGNALING; SILVER;

CELL MEMBRANES;

BETA 2 ADRENERGIC RECEPTOR; METAL NANOPARTICLE; SILVER;

ANIMAL; ARTICLE; CELL LINE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; FLUORESCENCE MICROSCOPY; METABOLISM; METHODOLOGY; MOUSE; MUSCLE CELL; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; CELL LINE; CELL MEMBRANE; METAL NANOPARTICLES; MICE; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUSCLE CELLS; RECEPTORS, ADRENERGIC, BETA-2; SILVER; SPECTRUM ANALYSIS, RAMAN;

EID: 69549124383     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn900488u     Document Type: Article

References (47)

1. v1.2. Science 2001, 293, 98-101.
2. Hall, R. A.; Lefkowitz, R. J. Regulation of G-Protein-Coupled Receptor Signaling by Scaffold Proteins. Circ. Res. 2002, 91, 672-680.
3. Razani, B.; Woodman, S. E.; Lisanti, M. P. Caveolae: From Cell Biology to Animal Physiology. Pharmacol. Rev. 2002, 54, 431-467.
4. Rybin, V. O.; Xu, X. H.; Lisanti, M. P.; Steinberg, S. F. Differential Targeting of Beta-Adrenergic Receptor Subtypes and Adenylyl Cyclase to Cardiomyocyte CaveolaeOA Mechanism to Functionally Regulate the cAMP Signaling Pathway. J. Biol. Chem. 2000, 275, 41447-41457.
5. Coulon, V.; Audet, M.; Homburger, V.; Bockaert, J.; Fagni, L.; Bouvier, M.; Perroy, J. Subcellular Imaging of Dynamic Protein Interactions by Bioluminescence Resonance Energy Transfer. Biophys. J. 2008, 94, 1001-1009.
6. 2-Adrenergic Receptors is Defined by Differential Interactions with PDE4. EMBO J. 2008, 27, 384-393.
7. Ianoul, A.; Grant, D. D.; Rouleau, Y.; Bani-Yaghoub, M.; Johnston, L. J.; Pezacki, J. P. Imaging Nanometer Domains of β-Adrenergic Receptor Complexes on the Surface of Cardiac Myocytes. Nat. Chem. Biol. 2005, 1, 196-202.
8. Bouvier, M. Oligomerization of G-Protein-Coupled Transmitter Receptors. Nat. Rev. Neurosci. 2001, 2, 274-286.
9. Rockman, H. A.; Koch, W. J.; Lefkowitz, R. J. Seven- Transmembrane- Spanning Receptors and Heart Function. Nature 2002, 415, 206-212.
10. Dorsch, S.; Klotz, K. N.; Engelhardt, S.; Lohse, M. J.; Bunemann, M. Analysis of Receptor Oligomerization by FRAP Microscopy. Nat. Methods 2009, 6, 225-230.
11. 2- Adrenergic G Protein-Coupled Receptor. Science 2007, 318, 1258-1265.
12. 2 Adrenergic G-Protein-Coupled Receptor. Nature 2007, 450, 383-387.
13. 2-Adrenergic Receptor Function. Science 2007, 318, 1266-1273.
14. 2 Adrenergic Receptor in Living Cells. Biochem. Biophys. Res. Commun. 2006, 343, 1191-1196.
15. 2-Adrenergic Receptor Dimerization in Living Cells Using Bioluminescence Resonance Energy Rransfer (BRET). Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 3684-3689.
16. 2-Adrenergic Receptor Dimers and Oligomers. Biol. Chem. 2003, 384, 117-123.
17. 2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting. J. Biol. Chem. 2004, 279, 33390-33397.
18. 3-Adrenergic Receptors Generates a β- Adrenergic Signaling Unit with Distinct Functional Properties. J. Biol. Chem. 2004, 279, 28756-28765.
19. Vobornik, D.; Rouleau, Y.; Haley, J.; Bani-Yaghoub, M.; Taylor, R.; Johnston, L. J.; Pezacki, J. P. Nanoscale Organization of Beta2-Adrenergic Receptor-Venus Fusion Protein Domains on the Surface of Mammalian Cells. Biochem. Biophys. Res. Commun. 2009, 382, 85-90.
20. Cao, Y. W. C.; Jin, R. C.; Mirkin, C. A. Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA Detection. Science 2002, 297, 1536-1540.
21. Durr, N. J.; Larson, T.; Smith, D. K.; Korgel, B. A.; Sokolov, K.; Ben-Yakar, A. Two-Photon Luminescence Imaging of Cancer Cells Using Molecularly Targeted Gold Nanorods. Nano Lett. 2007, 7, 941-945. (Pubitemid 46717737)
22. Hurst, S. J.; Hill, H. D.; Mirkin, C. A. "Three-Dimensional Hybridization" with Polyvalent DNA-Gold Nanoparticle Conjugates. J. Am. Chem. Soc. 2008, 130, 12192-12200.
23. Kneipp, J.; Kneipp, H.; Kneipp, K. SERS: A Single-Molecule and Nanoscale Tool for Bioanalytics. Chem. Soc. Rev. 2008, 37, 1052-1060.
24. Kneipp, K.; Kneipp, H.; Kneipp, J. Surface-Enhanced Raman Scattering in Local Optical Fields of Silver and Gold NanoaggregatessOFrom Single-Molecule Raman Spectroscopy to Ultrasensitive Probing in Live Cells. Acc. Chem. Res. 2006, 39, 443-450.
25. Qian, X. M.; Nie, S. M. Single-Molecule and Single- Nanoparticle SERSOFrom Fundamental Mechanisms to Biomedical Applications. Chem. Soc. Rev. 2008, 37, 912-920.
26. Roca, M.; Haes, A. J. Probing Cells with Noble Metal Nanoparticle Aggregates. Nanomedicine 2008, 3, 555-565.
27. Hu, Q.; Tay, L. L.; Noestheden, M.; Pezacki, J. P. Mammalian Cell Surface Imaging with Nitrile-Functionalized Nanoprobes: Biophysical Characterization of Aggregation and Polarization Anisotropy in SERS Imaging. J. Am. Chem. Soc. 2007, 129, 14-15.
28. Huang, X.; El-Sayed, I. H.; Qian, W.; El-Sayed, M. A. Cancer Cells Assemble and Align Gold Nanorods Conjugated to Antibodies to Produce Highly Enhanced, Sharp, and Polarized Surface Raman Spectra: A Potential Cancer Diagnostic Marker. Nano Lett. 2007, 7, 1591-1597.
29. Suydam, I. T.; Snow, C. D.; Pande, V. S.; Boxer, S. G. Electric Fields at the Active Site of an Enzyme: Direct Comparison of Experiment with Theory. Science 2006, 313, 200-204.
30. Noestheden, M.; Hu, Q.; Tay, L. L.; Tonary, A. M.; Stolow, A.; MacKenzie, R.; Tanha, J.; Pezacki, J. P. Synthesis and Characterization of CN-Modified Protein Analogues as Potential Vibrational Contrast Agents. Bioorg. Chem. 2007, 35, 284-293.
31. Szafranski, C. A.; Tanner, W.; Laibinis, P. E.; Garrell, R. L. Surface-Enhanced Raman Spectroscopy of Aromatic Thiols and Disulfides on Gold Electrodes. Langmuir 1998, 14, 3570-3579.
32. Friedrich, M. G.; Kirste, V. U.; Zhu, J.; Gennis, R. B.; Knoll, W.; Naumann, R. L. Activity of Membrane Proteins Immobilized on Surfaces as a Function of Packing Density. J. Phys. Chem. B 2008, 112, 3193-3201.
33. Zheng, M.; Li, Z.; Huang, X. Ethylene Glycol Monolayer Protected Nanoparticles: Synthesis, Characterization, and Interactions with Biological Molecules. Langmuir 2004, 20, 4226-4235.
34. Socrates, G., Infrared and Raman Characteristics Group Frequencies, Tables and Charts, 3rd ed.; John Wiley and Sons Ltd.: Toronto, 2005.
35. Anker, J. N.; Hall, W. P.; Lyandres, O.; Shah, N. C.; Zhao, J.; Van Duyne, R. P. Biosensing with Plasmonic Nanosensors. Nat. Mater. 2008, 7, 442-453.
36. McFarland, A. D.; Young, M. A.; Dieringer, J. A.; Van Duyne, R. P. Wavelength-Scanned Surface-Enhanced Raman Excitation Spectroscopy. J. Phys. Chem. B 2005, 109, 11279-11285.
37. Willets, K. A.; Van Duyne, R. P. Localized Surface Plasmon Resonance Spectroscopy and Sensing. Annu. Rev. Phys. Chem. 2007, 58, 267-297.
38. 2-Adrenergic Receptor Subtypes Optimizes β-Adrenergic Modulation of Cardiac Contractility. Circ. Res. 2005, 97, 244-251.
39. Qian, X.; Peng, X. H.; Ansari, D. O.; Yin-Goen, Q.; Chen, G. Z.; Shin, D. M.; Yang, L.; Young, A. N.; Wang, M. D.; Nie, S. In Vivo Tumor Targeting and Spectroscopic Detection with Surface-Enhanced Raman Nanoparticle Tags. Nat. Biotechnol. 2008, 26, 83-90.
40. Xu, H.; Bjerneld, E. J.; Kall, M.; Borjesson, L. Spectroscopy of Single Hemoglobin Molecules by Surface Enhanced Raman Scattering. Phys. Rev. Lett. 1999, 83, 4357-4360.
41. Day, P. W.; Rasmussen, S. G.; Parnot, C.; Fung, J. J.; Masood, A.; Kobilka, T. S.; Yao, X. J.; Choi, H. J.; Weis, W. I.; Rohrer, D. K.; Kobilka, B. K. A Monoclonal Antibody for G Protein- Coupled Receptor Crystallography. Nat. Methods 2007, 4, 927-929.
42. Yang, E. V.; Sood, A. K.; Chen, M.; Li, Y.; Eubank, T. D.; Marsh, C. B.; Jewell, S.; Flavahan, N. A.; Morrison, C.; Yeh, P. E.; Lemeshow, S.; Glaser, R. Norepinephrine Up- Regulates the Expression of Vascular Endothelial Growth Factor, Matrix Metalloproteinase (MMP)-2, and MMP-9 in Nasopharyngeal Carcinoma Tumor Cells. Cancer Res. 2006, 66, 10357-10364.
43. Yguerabide, J.; Yguerabide, E. E. Light-Scattering Submicroscopic Particles as Highly Fluorescent Analogs and Their Use as Tracer Labels in Clinical and Biological Applications. Anal. Biochem. 1998, 262, 157-176. (Pubitemid 28452775)
44. Liu, G. L.; Yin, Y.; Kunchakarra, S.; Mukherjee, B.; Gerion, D.; Jett, S. D.; Bear, D. G.; Gray, J. W.; Alivisatos, A. P.; Lee, L. P.; Chen, F. F. A Nanoplasmonic Molecular Ruler for Measuring Nuclease Activity and DNA Footprinting. Nat. Nanotechnol. 2006, 1, 47-52.
45. Sonnichsen, C.; Reinhard, B. M.; Liphardt, J.; Alivisatos, A. P. A Molecular Ruler Based on Plasmon Coupling of Single Gold and Silver Nanoparticles. Nat. Biotechnol. 2005, 23, 741-745.
46. Wang, H.; Huff, T. B.; Zweifel, D. A.; He, W.; Low, P. S.; Wei, A.; Cheng, J. X. In Vitro and In Vivo Two-Photon Luminescence Imaging of Single Gold Nanorods. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 15752-15756.
47. Moskovits, M. Surface-Enhanced Spectroscopy. Rev. Mod. Phys. 1985, 57, 783-826.