Gap junctions mediate the spread of ischemia-reperfusion injury

Circulation Journal

Volumn 73, Issue 9, 2009, Pages 1591-1592

  Minamino, Tohru ^a,b  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CARBENOXOLONE; CONNEXIN 43; GAP JUNCTION PROTEIN;

CELL MEMBRANE; EDITORIAL; EXCITATION; GAP JUNCTION; HEART; HEART ARRHYTHMIA; HEART CONTRACTION; HEART DISEASE; HEART ELECTROPHYSIOLOGY; HEART INFARCTION; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RHYTHM; HUMAN; ISCHEMIA REPERFUSION INJURY; NONHUMAN; OLIGOMERIZATION; PATHOLOGY; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ANIMALS; CELL COMMUNICATION; CONNEXIN 43; GAP JUNCTIONS; HUMANS; ISCHEMIC CONTRACTURE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NECROSIS; PHOSPHORYLATION; PROTEIN TRANSPORT; TIME FACTORS; UP-REGULATION;

EID: 69549119810     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-09-0342     Document Type: Editorial

References (11)

1. Severs NJ, Coppen SR, Dupont E, Yeh HJ, Ko YS, Matsushita T. Gap junction alterations in human cardiac disease. Cardiovasc Res 2004; 62: 368-377. (Pubitemid 38496549)
2. Severs NJ, Bruce AF, Dupont E, Rothery S. Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res 2008; 80: 9-19.
3. Solan JL, Lampe PD. Connexin43 phosphorylation: Structural changes and biological effects. Biochem J 2009; 419: 261-272.
4. Lerner DL, Yamada KA, Schuessler RB, Saffitz JE. Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice. Circulation 2000; 101: 547-552.
5. Kanno S, Kovacs A, Yamada KA, Saffitz JE. Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice. J Am Coll Cardiol 2003; 41: 681-686. (Pubitemid 36223337)
6. Shintani-Ishida K, Unuma K, Yoshida K. Ischemia enhances translocation of connexin43 and gap junction intercellular communication, thereby propagating contraction band necrosis after reperfusion. Circ J 2009; 73: 1661-1668.
7. Garcia-Dorado D, Rodriguez-Sinovas A, Ruiz-Meana M. Gap junction-mediated spread of cell injury and death during myocardial ischemia-reperfusion. Cardiovasc Res 2004; 61: 386-401. (Pubitemid 38210146)
8. Miyazaki S, Fujiwara H, Onodera T, Kihara Y, Matsuda M, Wu DJ, et al. Quantitative analysis of contraction band and coagulation necrosis after ischemia and reperfusion in the porcine heart. Circulation 1987; 75: 1074-1082. (Pubitemid 17068539)
9. Matsuda M, Fujiwara H, Onodera T, Tanaka M, Wu DJ, Fujiwara T, et al. Quantitative analysis of infarct size, contraction band necrosis, and coagulation necrosis in human autopsied hearts with acute myocardial infarction after treatment with selective intracoronary thrombolysis. Circulation 1987; 76: 981-989. (Pubitemid 17157278)
10. Garcia-Dorado D, Inserte J, Ruiz-Meana M, Gonzalez MA, Solares J, Julia M, et al. Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion. Circulation 1997; 96: 3579-3586. (Pubitemid 27513436)
11. Yip HK, Chang LT, Wu CJ, Sheu JJ, Youssef AA, Pei SN, et al. Autologous bone marrow-derived mononuclear cell therapy prevents the damage of viable myocardium and improves rat heart function following acute anterior myocardial infarction. Circ J 2008; 72: 1336-1345.