Half-life of antiseptics is the key: Evidence from theory, experimentation and practice

Round Table Series - Royal Society of Medicine

Volumn , Issue 85, 2007, Pages 1-19

  Hill, Robert L R ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANTIINFECTIVE AGENT; CHLORHEXIDINE;

ANTIBIOTIC RESISTANCE; BACTERIAL INFECTION; BACTERIAL TRANSMISSION; CONFERENCE PAPER; DISINFECTION; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; EVIDENCE BASED MEDICINE; EXPERIMENTAL STUDY; HAND INFECTION; HAND WASHING; HUMAN; HYGIENE; IN VIVO STUDY; MEDICAL PRACTICE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROORGANISM; NONHUMAN; PATIENT COMPLIANCE; PROFESSIONAL PRACTICE;

EID: 69549112822     PISSN: 02683091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (41)

1. Department of Health. Getting Ahead of the Curve - A Strategy for Combating Infectious Diseases (Including Other Aspects of Health Protection). London: Department of Health, 2002.
2. Stone S, Teare L, Cookson B. Guiding hands of our teachers. Lancet 2001; 357: 479-480
3. Pittet D, Hugonnet S, Harbath S et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Lancet 2000; 356: 1307-1312 (Pubitemid 30831854)
4. Tear EI, Cookson B, French GL et al. UK hand washing initiative. J Hosp Infect 1999; 43: 1-3.
5. Stein AD, Makarawo TP, Ahmad MFR. A survey of doctors' and nurses' knowledge, attitudes and compliance with infection control guidelines in Birmingham teaching hospitals. J Hosp Infect 2003; 54: 68-73.
6. Hill RLR. Prevention of transmission of antibiotic-resistant pathogens by fingers: role and determination of antiseptic half-life. In: Hill RLR, ed. Progressing Antiseptic Development to Reduce Transmission of Antibiotic-Resistant Pathogens. London: RSM Press, 2006: 47-56.
7. Reybrouck G. Hand washing and hand disinfection. J Hosp infect 1983; 8: 5-23.
8. Hill RLR. Half-life of hand washing agents Is the key - a simulation model of infection control. Abstract presented at the Fifth Conference of the Hospital Infection Society, Edinburgh, UK, 15-18 September 2002.
9. Lowbury EJL, Lilly H, Bull JP. Disinfection of hands: removal of transient organisms. BMJ 1964; ii: 531-536
10. Xlabadie J-C, Kampf G, Lejeune B et al. Recommendations for surgical hand disinfection - requirements, implementation and need for research. A proposal by representatives of the SFHH, DGHM and DGKH for a European discussion. J Hosp Infect 2002; 51: 312-315 (Pubitemid 38001884)
11. Casewell MW, Law MM, Desai N. A laboratory model for testing agents for hygienic hand disinfection: hand washing and chlorhexidine for the removal of Klebsiella. J Hosp Infect 1988; 12: 163-175 (Pubitemid 18269470)
12. Wade JJ, Casewell MW. The evaluation of residual antimicrobial activity on hands and its clinical relevance. J Hosp Infect 1991; 18 (suppl B): 23-28
13. Wise R. Pharmacology and pharmacokinetics. In: Reeves DS, Wise R, Andrews JM et al, eds. Clinical Antimicrobial Assays. Oxford: Oxford University Press, 1999: 11-25.
14. Boyce JM, Pittet D. Guideline for hand hygiene In health-care settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. MMWR 2002; 51: 1-44. (Pubitemid 36009085)
15. Food and Drug Administration. Tentative final monograph for healthcare antiseptic drug products; proposed rule. Fed Regist 1994; 59: 31441-31452
16. European Committee for Standardization. Chemical Disinfectants and Antiseptics - Hygienic Handrub - Test Method and Requirements (Phase2/Step2) [European Standard EN 1500]. Brussels: Central Secretariat, 1997.
17. Rotter ML, Hirschl AM, Koller W. Effect of chlorhexidine-containing detergent, non-medicated soap or isopropanol and the influence of neutralizer on bacterial pathogenicity. J Hosp Infect 1988; 11: 220-225 (Pubitemid 18129441)
18. Marples RR, Towers AG. A laboratory model for the investigation of contact transfer of microorganisms. J Hyg (Lond) 1979; 82: 237-248
19. Pittet D, Dharan S, Touveneau S, Sauvan V, Perneger TV. Bacterial contamination of the hands of hospital staff during routine patient care. Arch Intern Med 1999; 159: 821-826 (Pubitemid 29200308)
20. Hill RLR. The half-life of hand washing agents on fingertips is potentially important for the amelioration of non-compliant hand hygiene. J Infect 2003; 46: P16-265.
21. Boyce JM. Antiseptic technology: access, affordability, and acceptance. Emerg Infect Dis 2001; 7: 1-7.
22. Bootsma MC, Diekmann O, Bonten MJ. Controlling methicillin-resistant Staphylococcus aureus: quantifying the effects of interventions and rapid diagnostic testing. Proc Natl Acad Sci USA 2006; 103: 5620-5625
23. Casewell MW, Phillips I. Hands as a route of transmission for Klebsiella species. BMJ 1977; 2: 1315-1317 (Pubitemid 8233316)
24. Cooper BS, Stone SP, Kibbler CC et al. Systematic review of isolation policies in the hospital management of methicillin-resistant Staphylococcus aureus: a review of the literature with epidemiological and economic modelling. Health Technol Assess 2003; 7: 1-194.
25. Doebbeling BN, Stanley GL, Sheetz CT et al. Comparative efficacy of alternative hand-washing agents in reducing nosocomial infections in intensive care units. N Engl J Med 1992; 327: 88-93.
26. Ward TT, Winn RE, Hartstein AI, Sewell DL. Observations relating to an inter-hospital of methicillin-resistant Staphylococcus aureus: role of antimicrobial therapy in infection control. Infect Control 1981; 2: 453-459
27. Hill RLR, Duckworth GD, Casewell MW. Elimination of nasal carriage of methicillin-resistant Staphylococcus aureus with mupirocin during a hospital outbreak. J Antimicrob Chemother 1988; 22: 377-384 (Pubitemid 18227119)
28. Duckworth GJ, Lothian JL, Williams JD. Methicillin-resistant Staphylococcus aureus: report of an outbreak in a London teaching hospital. J Hosp Infect 1988; 11: 1-15. (Pubitemid 18117963)
29. Kermack WO, McKendrick AG. A contribution to the mathematical theory of epidemics. Proc R Soc Lond A 1927; 115: 700-722
30. Casewell MW, Hill RLR. Pseudomonic acid and control of methicillin-resistant staphylococci. Lancet 1983; ii: 1312.
31. Casewell MW, Hill RLR. The laboratory assessment of the anti-staphylococcal activity of mupirocin (pseudomonic acid). In: Wilkinson DS, Price JD, eds. Mupirocin: A Novel Topical Antibiotic. London: RSM Press, 1984: 57-64.
32. Casewell MW, Hill RLR. In-vitro activity of mupirocin ('pseudomonic acid') against clinical isolates of Staphylococcus aureus. J Antimicrob Chemother 1985; 5: 523-531 (Pubitemid 15093192)
33. Casewell MW, Hill RLR. Elimination of nasal carriage of Staphylococcus aureus with mupirocin ('pseudomonic acid') - a controlled trial. J Antimicrob Chemother 1986; 17: 365-372
34. Pittet D, Hugonnet S, Harbarth S et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Lancet 2000; 356: 1307-1312 (Pubitemid 30831854)
35. Johnson PDR, Martin R, Burrell LJ et al. Efficacy of an alcohol/chlorhexidine hand hygiene program in a hospital with high rates of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection. Med J Aust 2005; 183: 509-514 (Pubitemid 41723325)
36. Kramer A, Rudolf P, Kampf G, Pittet D. Limited efficacy of alcohol-based hand gels. Lancet 2002; 359: 1489-1490 (Pubitemid 34457771)
37. Holland KT, Bojar RA. Development and testing strategies for antiseptics. In: Hill RLR, ed. Progressing Antiseptic Development to Reduce Transmission of Antibiotic-Resistant Pathogens. London: RSM Press, 2006: 39-46.
38. Hill RLR. The bioavailability of mupirocin in nasal secretions in vitro. J Clin Path 2002; 55: 223-235
39. Hill RLR, Casewell MW. The in-vitro activity of povidone-iodine cream against Staphylococcus aureus and its bioavailability in nasal secretions. J Hosp Infect 2000; 45: 198-205.
40. Bush LW, Benson LM, White JH. Pig skin as test substrate for evaluating topical antimicrobial activity. J Clin Microbiol 1986; 24: 343-348
41. Messager S, Goddard P, Dettmear PW, Maillard JY. Comparison of two in-vlvo and two ex-vivo tests to assess the antibacterial activity of several antiseptics. J Hosp Infect 2004; 58: 115-121 (Pubitemid 39317882)