Muscle relaxant and neurotoxic activities of intrathecal baclofen in rats

Pharmacological Research

Volumn 60, Issue 5, 2009, Pages 392-396

  Kuroiwa, Miho ^a   Kitano, Yutaka ^a   Takasuna, Kiyoshi ^a   Manabe, Sunao ^a   Saito, Takao ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Baclofen; Decerebrate rigidity; Electroencephalogram; Intrathecal; Muscle relaxant; Spasticity

Indexed keywords

BACLOFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; HIPPOCAMPUS; MALE; MUSCLE RELAXATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR CORTEX; SPASTICITY;

ANIMALS; BACLOFEN; DECEREBRATE STATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; HUMANS; INJECTIONS, INTRAVENOUS; INJECTIONS, SPINAL; MALE; MUSCLE RELAXANTS, CENTRAL; RATS; RATS, WISTAR;

EID: 69549111033     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.06.010     Document Type: Article

References (41)

1. B receptors: first of the functional metabotropic heterodimers. J Pharmacol Exp Ther 292 (2000) 2-7
2. B receptors: structure and function. Pharmacol Rev 54 (2002) 247-264
3. Malcangio M., and Bowery N.G. GABA and its receptors in the spinal cord. Trends Pharmacol Sci 17 (1996) 457-462
4. McDowell F.H. Treatment of spasticity. Drugs 22 (1981) 401-408
5. Penn R.D., and Kroin J.S. Intrathecal baclofen alleviates spinal cord spasticity. Lancet 323 (1984) 1078
6. Penn R.D., and Kroin J.S. Continuous intrathecal baclofen for severe spasticity. Lancet 326 (1985) 125-127
7. Penn R.D., Savoy S.M., Corcos D., Latash M., Gottlieb G., Parke B., et al. Intrathecal baclofen for severe spinal spasticity. N Engl J Med 320 (1989) 1517-1521
8. Penn R.D. Intrathecal baclofen for spasticity of spinal origin: seven years of experience. J Neurosurg 77 (1992) 236-240
9. Coffey R.J., Cahill D., Steers W., Park T.S., Ordia J., Meythaler J., et al. Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study. J Neurosurg 78 (1993) 226-232
10. Guillaume D., Van Havenbergh A., Vloeberghs M., Vidal J., and Roeste G. A clinical study of intrathecal baclofen using a programmable pump for intractable spasticity. Arch Phys Med Rehabil 86 (2005) 2165-2171
11. Meythaler J.M., Guin-Renfroe S., Law C., Grabb P., and Hadley M.N. Continuously infused intrathecal baclofen over 12 months for spastic hypertonia in adolescents and adults with cerebral palsy. Arch Phys Med Rehabil 82 (2001) 155-161
12. Sadiq S.A., and Wang G.C. Long-term intrathecal baclofen therapy in ambulatory patients with spasticity. J Neurol 253 (2006) 563-569
13. Yamamoto H., Kuki M., and Ozaki M. The absorption, distribution, metabolism and elimination of β-(p-chlorophenyl)-GABA (baclofen) (1) Absorption and fate of baclofen in rats. Oyo Yakuri 14 (1977) 97-108
14. Fukuda H., Ito T., Hashimoto S., and Kudo Y. Rigidity in rats due to anemic decerebration and the effect of chlorpromazine. Jpn J Pharmacol 24 (1974) 810-813
15. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 2nd ed. (1986), Academic Press Inc., Sydney
16. Bishop B. Spasticity: its physiology and management. Part I. Neurophysiology of spasticity: classical concepts. Phys Ther 57 (1977) 371-376
17. Davis R.A., and Davis L. Decerebrate rigidity in animals. Neurosurgery 9 (1981) 79-89
18. Goto M., Kondo M., and Fukuda H. Effects of barbiturates on the decerebrate rigidity in rats. J Pharmacobiodyn 5 (1982) 643-652
19. Goto M., Ono H., Matsumoto K., Kondo M., and Fukuda H. Effects of zopiclone and benzodiazepines on spinal reflexes, anemic decerebrate rigidity and benzodiazepine binding. Jpn J Pharmacol 33 (1983) 1241-1246
20. Morikawa K., Oshita M., Yamazaki M., Ohara N., Mizutani F., Kato H., et al. Pharmacological studies of the new centrally acting muscle relaxant 4′-ethyl-2-methyl-3-pyrrolidinopropiophenone hydrochloride. Arzneimittelforschung 37 (1987) 331-336
21. Ochiai T., and Ishida R. Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant (II) Effects on the spinal reflex potential and the rigidity. Jpn J Pharmacol 32 (1982) 427-438
22. Ono H., Matsumoto K., Kato K., Kato F., Miyamoto M., Mori T., et al. Effects of tizanidine, a centrally acting muscle relaxant, on motor systems. Gen Pharmacol 17 (1986) 137-142
23. Ono H., Saito K., Kondo M., Morishita S., Kato K., Hasebe Y., et al. Effects of the new centrally acting muscle relaxant 7-chloro-N,N 3-trimethylbenzo[b]furan-2-carboxamide on motor and central nervous systems in rats. Arzneimittelforschung 40 (1990) 730-735
24. Otsu T., Kawabata H., Horikomi K., Tanada H., Sakai K., Matsubara A., et al. Pharmacological properties of the new centrally acting muscle relaxant (R)-(+)-3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl]isoxazole hydrochloride. Arzneimittelforschung 47 (1997) 706-709
25. Sakitama K., Ozawa Y., Aoto N., Nakamura K., and Ishikawa M. Pharmacological properties of NK433, a new centrally acting muscle relaxant. Eur J Pharmacol 273 (1995) 47-56
26. Togari A., Kudo Y., and Fukuda H. Effects of barbiturates on the decerebrate rigidity in rats. J Pharmacobiodyn 1 (1978) 332-337
27. ® Ciba 34 647-Ba). J Int Med Res 2 (1974) 36-47
28. Fukuda H. Effects of diazepam and baclofen on the anemic decerebrate rigidity in rats. Nippon Yakurigaku Zasshi 75 (1979) 535-542
29. Ito T., Hori M., Furukawa K., Karasawa T., and Kadokawa T. Pharmacological studies of 1-(2,3-dimethyl-4-methoxyphenyl)-2-methyl-3-(1-pyrrolidinyl)-1-propanone hydrochloride (AD-2239), a centrally acting muscle relaxant. Arch Int Pharmacodyn Ther 275 (1985) 105-122
30. Kawajiri S., Kojima H., and Akashi A. A comparison of the effects of baclofen and some other muscle relaxants on α-rigidity in rats. Nippon Yakurigaku Zasshi 83 (1984) 263-268
31. Klockgether T., Schwarz M., Wüllner U., Turski L., and Sontag K.H. Myorelaxant effect after intrathecal injection of antispastic drugs in rats. Neurosci Lett 97 (1989) 221-226
32. Kakinohana O., Hefferan M.P., Nakamura S., Kakinohana M., Galik J., Tomori Z., et al. Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study. Neuroscience 141 (2006) 1569-1583
33. Yokoi I., Akiyama K., Kabuto H., Fukuyama K., Nishijima Y., and Mori A. Peripheral acting muscle relaxants alter the effects of baclofen on the electrocorticograms in the rat. J Neural Transm Gen Sect 87 (1992) 37-47
34. Lembeck F., and Beubler E. Convulsions induced by hyperbaric oxygen: inhibition by phenobarbital, diazepam and baclofen. Naunyn Schmiedebergs Arch Pharmacol 297 (1977) 47-51
35. Meldrum B. GABAergic agents as anticonvulsants in baboons with photosensitive epilepsy. Neurosci Lett 47 (1984) 345-349
36. Van Rijn C.M., Van Berlo M.J., Feenstra M.G., Schoofs M.L., and Hommes O.R. R(-)-baclofen: focal epilepsy after intracortical administration in the rat. Epilepsy Res 1 (1987) 321-327
37. Darbari F.P., Melvin J.J., Piatt Jr. J.H., Adirim T.A., and Kothare S.V. Intrathecal baclofen overdose followed by withdrawal: clinical and EEG features. Pediatr Neurol 33 (2005) 373-377
38. Hormes J.T., Benarroch E.E., Rodriguez M., and Klass D.W. Periodic sharp waves in baclofen-induced encephalopathy. Arch Neurol 45 (1998) 814-815
39. Paulson G.W. Overdose of Lioresal. Neurology 26 (1976) 1105-1106
40. Wainapel S.F., Lee L., and Riley T.L. Reversible electroencephalogram changes associated with administration of baclofen in a quadriplegic patient: case report. Paraplegia 24 (1986) 123-126
41. Weissenborn K., Wilkens H., and Degen P.H. Burst suppression EEG with baclofen overdose. Clin Neurol Neurosurg 93 (1991) 77-79