Overcorrection of hyponatremia is a medical emergency

Kidney International

Volumn 76, Issue 6, 2009, Pages 587-589

  Sterns, Richard H ^a,b   Hix, John K ^a,b  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DESMOPRESSIN; GLUCOSE; SODIUM;

DIURESIS; EMERGENCY MEDICINE; HUMAN; HYPONATREMIA; NEPHROLOGIST; NONHUMAN; NOTE; PRIORITY JOURNAL; SODIUM BLOOD LEVEL; WATER RETENTION;

CARBON DIOXIDE; DEMYELINATING DISEASES; EMERGENCIES; HUMANS; HYPONATREMIA; MYELINOLYSIS, CENTRAL PONTINE; OXYGEN; SODIUM;

EID: 69549108912     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.251     Document Type: Note

References (14)

1. Berl T. Treating hyponatremia: damned if we do and damned if we don't. Kidney Int 1990; 37: 1006-1018.
2. Kokko JP. Symptomatic hyponatremia with hypoxia is a medical emergency. Kidney Int 2006; 69: 1291-1293.
3. Ayus JC, Armstrong D, Arieff AI. Hyponatremia with hypoxia: effects on brain adaptation, perfusion, and histology in rodents. Kidney Int 2006; 69: 1319-1325.
4. Gankam Kengne F, Soupart A, Pochet R et al. Re-induction of hyponatremia following rapid overcorrection of hyponatremia reduces mortality in rats. Kidney Int 2009; 76: 614-621.
5. Perianayagam A, Sterns RH, Silver SM et al. DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia. Clin J Am Soc Nephrol 2008; 3: 331-336.
6. Sterns RH, Nigwekar SU, Hix JK. The treatment of hyponatremia. Semin Nephrol 2009; 29: 282-299.
7. Whelan B, Bennett K, O'Riordan D, Silke B. Serum sodium as a risk factor for in-hospital mortality in acute unselected general medical patients. QJM 2009; 102: 175-182.
8. Ayus JC, Arieff AI. Chronic hyponatremic encephalopathy in postmenopausal women: association of therapies with morbidity and mortality. JAMA 1999; 281: 2299-2304.
9. Muller TB, Haraldseth O, Jones RA et al. Combined perfusion and diffusion-weighted magnetic resonance imaging in a rat model of reversible middle cerebral artery occlusion. Stroke 1995; 26: 451-457; discussion 457-458.
10. Noth U, Kotajima F, Deichmann R et al. Mapping of the cerebral vascular response to hypoxia and hypercapnia using quantitative perfusion MRI at 3 T. NMR Biomed 2008; 21: 464-472. (Pubitemid 351895434)
11. Adler S, Verbalis JG, Williams D. Effect of rapid correction of hyponatremia on the blood-brain barrier of rats. Brain Res 1995; 679: 135-143.
12. Vootukuru S, Kadam S, Kouides R, Sterns R. Outcomes of severe symptomatic hyponatremia and effect of hypoxia. J Am Soc Nephrol 2007; 18: 790A, abstr.
13. Sterns RH. Severe symptomatic hyponatremia: treatment and outcome. A study of 64 cases. Ann Intern Med 1987; 107: 656-664. (Pubitemid 18041860)
14. Mohmand HK, Issa D, Ahmad Z et al. Hypertonic saline for hyponatremia: risk of inadvertent overcorrection. Clin J Am Soc Nephrol 2007; 2: 1110-1117.