Method for the selective measurement of amino-terminal variants of procalcitonin

Clinical Chemistry

Volumn 55, Issue 9, 2009, Pages 1672-1679

  Struck, Joachim ^a   Strebelow, Martina ^b   Tietz, Sonja ^b   Alonso, Christine ^a   Morgenthaler, Nils G ^a   Van Der Hoeven, Johannes G ^c   Pickkers, Peter ^c   Bergmann, Andreas ^a  

^a BRAHMS AG   (Germany)

^b Unicus Karlsburg OHG   (Germany)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PROCALCITONIN; PROCALCITONIN[1-116]; PROCALCITONIN[3-116]; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CROSS REACTION; ENDOTOXEMIA; HUMAN; HUMAN EXPERIMENT; IMMUNOASSAY; KINETICS; LUMINESCENCE IMMUNOASSAY; MEASUREMENT; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CALCITONIN; CROSS REACTIONS; ENDOTOXEMIA; EPITOPES; HUMANS; IMMUNOASSAY; KINETICS; MOLECULAR SEQUENCE DATA; PROTEIN PRECURSORS; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS);

EID: 69549096361     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2008.123018     Document Type: Article

References (27)

1. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993;341:515-518 (Pubitemid 23066085)
2. Muller B, Becker KL, Schachinger H, Rickenbacher PR, Huber PR, Zimmerli W, Ritz R. Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med 2000;28:977-983 (Pubitemid 30262065)
3. Harbarth S, Holeckova K, Froidevaux C, Pittet D, Ricou B, Grau GE, et al. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 2001;164:396-402. (Pubitemid 32778205)
4. Becker KL, Snider R, Nylen ES. Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit Care Med 2008;36:941-952
5. Becker KL, Nylen ES, White JC, Muller B, Snider RH Jr. Clinical review 167: Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab 2004;89:1512-1525 (Pubitemid 38507896)
6. Nobre V, Harbarth S, Graf JD, Rohner P, Pugin J. Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. Am J Respir Crit Care Med 2008;177:498-505.
7. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, Muller B. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial. Lancet 2004;363:600-607 (Pubitemid 38264177)
8. Stolz D, Christ-Crain M, Bingisser R, Leuppi J, Miedinger D, Muller C, et al. Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapy. Chest 2007;131:9-19. (Pubitemid 46122969)
9. Christ-Crain M, Stolz D, Bingisser R, Muller C, Miedinger D, Huber PR, et al. Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med 2006;174:84-93. (Pubitemid 43955248)
10. Briel M, Schuetz P, Mueller B, Young J, Schild U, Nusbaumer C, et al. Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care. Arch Intern Med 2008;168:2000-7, discussion 2007-2008
11. Sponholz C, Sakr Y, Reinhart K, Brunkhorst F. Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature. Crit Care 2006;10:R145. (Pubitemid 47086948)
12. Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 2006;34:1996-2003. (Pubitemid 43982479)
13. Wagner KE, Martinez JM, Vath SD, Snider RH, Nylen ES, Becker KL, et al. Early immunoneutralization of calcitonin precursors attenuates the adverse physiologic response to sepsis in pigs. Crit Care Med 2002;30:2313-2321
14. Nylen ES, Whang KT, Snider RH Jr, Steinwald PM, White JC, Becker KL. Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis [see Comments]. Crit Care Med 1998;26:1001-1006
15. Becker KL, Nylen ES, Snider RH, Muller B, White JC. Immunoneutralization of procalcitonin as therapy of sepsis. J Endotoxin Res 2003;9:367-374
16. Sexton PM, Christopoulos G, Christopoulos A, Nylen ES, Snider RH, Jr., Becker KL. Procalcitonin has bioactivity at calcitonin receptor family complexes: potential mediator implications in sepsis. Crit Care Med 2008;36:1637-1640 (Pubitemid 351620662)
17. Muller B, White JC, Nylen ES, Snider RH, Becker KL, Habener JF. Ubiquitous expression of the calcitonin-I gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab 2001;86:396-404. (Pubitemid 32109825)
18. Morgenthaler NG, Struck J, Chancerelle Y, Weglohner W, Agay D, Bohuon C, et al. Production of procalcitonin (PCT) in non-thyroidal tissue after LPS injection. Horm Metab Res 2003;35:290-295 (Pubitemid 37011514)
19. Weglohner W, Struck J, Fischer-Schulz C, Morgenthaler NG, Otto A, Bohuon C, Bergmann A. Isolation and characterization of serum procalcitonin from patients with sepsis. Peptides 2001;22:2099-2103
20. Wrenger S, Kahne T, Bohuon C, Weglohner W, Ansorge S, Reinhold D. Amino-terminal truncation of procalcitonin, a marker for systemic bacterial infections, by dipeptidyl peptidase IV (DP IV). FEBS Lett 2000;466:155-159 (Pubitemid 30050703)
21. Harlow E, Lane D. Antibodies: a laboratory manual. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory; 1988.
22. Lane RD. A short-duration polyethylene glycol fusion technique for increasing production of monoclonal antibody-secreting hybridomas. J Immunol Methods 1985;81:223-228
23. Morgenthaler NG, Struck J, Fischer-Schulz C, Bergmann A. Sensitive immunoluminometric assay for the detection of procalcitonin. Clin Chem 2002;48:788-790 (Pubitemid 34439119)
24. Ramakers BP, de Goeij M, van der Hoeven JG, Peters WH, Pickkers P. Inflammation-induced hepatotoxicity in humans. Shock 2009;31:151-156
25. Steinbach G, Rau B, Debard AL, Javourez JF, Bienvenu J, Ponzio A, et al. Multicenter evaluation of a new immunoassay for procalcitonin measurement on the Kryptor system. Clin Chem Lab Med 2004;42:440-449 (Pubitemid 38585189)
26. de Wolf HK, Gunnewiek JK, Berk Y, van den Ouweland J, de Metz M. Comparison of a new procalcitonin assay from Roche with the established method on the Brahms Kryptor. Clin Chem 2009;55:1043-1044
27. Dandona P, Nix D, Wilson MF, Aljada A, Love J, Assicot M, Bohuon C. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994;79:1605-1608