Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 9, 2009, Pages 1528-1537

  Zhu, Wei ^a,b   Fan, Yongfeng ^a   Hao, Qi ^a   Shen, Fanxia ^a   Hashimoto, Tomoki ^a   Yang, Guo Yuan ^a   Gasmi, Mehdi ^c   Bartus, Raymond T ^c   Young, William L ^a,d   Chen, Yongmei ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b FUDAN UNIVERSITY   (China)

^c Ceregene Inc   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Angiogenesis; IGF 1; Neurovascular; Regeneration; Stroke

Indexed keywords

BROXURIDINE; DOUBLECORTIN; GREEN FLUORESCENT PROTEIN; PARVOVIRUS VECTOR; SODIUM CHLORIDE; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG MECHANISM; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; IMMUNOHISTOCHEMISTRY; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGENERATION; SIGNAL TRANSDUCTION; STROKE; VASCULARIZATION;

ANIMALS; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MICE; MICROCIRCULATION; NEOVASCULARIZATION, PHYSIOLOGIC; REGIONAL BLOOD FLOW; TRANSDUCTION, GENETIC;

EID: 69549091706     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.75     Document Type: Article

References (29)

1. Burger C, Nash K, Mandel RJ (2005a) Recombinant adenoassociated viral vectors in the nervous system. Hum Gene Ther 16:781-791 (Pubitemid 40982327)
2. Burger C, Nguyen FN, Deng J, Mandel RJ (2005b) Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion. Mol Ther 11:327-331
3. Chan PH, Kinouchi H, Epstein CJ, Carlson E, Chen SF, Imaizumi S, Yang GY (1993) Role of superoxide dismutase in ischemic brain injury: reduction of edema and infarction in transgenic mice following focal cerebral ischemia. Prog Brain Res 96:97-104 (Pubitemid 23185286)
4. Chen J, Zhang C, Jiang H, Li Y, Zhang L, Robin A, Katakowski M, Lu M, Chopp M (2005) Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. J Cereb Blood Flow Metab 25:281-290 (Pubitemid 40171209)
5. Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD (1986) A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke 17:738-743
6. Cheng B, Mattson MP (1992) IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage. J Neurosci 12:1558-1566
7. Conti E, Carrozza C, Capoluongo E, Volpe M, Crea F, Zuppi C, Andreotti F (2004) Insulin-like growth factor-1 as a vascular protective factor. Circulation 110:2260-2265 (Pubitemid 39372511)
8. del Zoppo GJ (2006) Stroke and neurovascular protection. N Engl J Med 354:553-555
9. Dempsey RJ, Sailor KA, Bowen KK, Tureyen K, Vemuganti R (2003) Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: effect of exogenous IGF-1 and GDNF. J Neurochem 87:586-597 (Pubitemid 37310625)
10. Denti L, Annoni V, Cattadori E, Salvagnini MA, Visioli S, Merli MF, Corradi F, Ceresini G, Valenti G, Hoffman AR, Ceda GP (2004) Insulin-like growth factor 1 as a predictor of ischemic stroke outcome in the elderly. Am J Med 117:312-317 (Pubitemid 39164563)
11. Dluzniewska J, Sarnowska A, Beresewicz M, Johnson I, Srai SK, Ramesh B, Goldspink G, Gorecki DC, Zablocka B (2005) A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia. FASEB J 19:1896-1898 (Pubitemid 41598787)
12. Dore S, Kar S, Quirion R (1997) Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity. Proc Natl Acad Sci USA 94:4772-4777 (Pubitemid 27194319)
13. Gasmi M, Brandon EP, Herzog CD, Wilson A, Bishop KM, Hofer EK, Cunningham JJ, Printz MA, Kordower JH, Bartus RT (2007) AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease. Neurobiol Dis 27:67-76 (Pubitemid 46921475)
14. Gertz K, Priller J, Kronenberg G, Fink KB, Winter B, Schrock H, Ji S, Milosevic M, Harms C, Bohm M, Dirnagl U, Laufs U, Endres M (2006) Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow. Circ Res 99:1132-1140 (Pubitemid 44729938)
15. Gross CG (2000) Neurogenesis in the adult brain: death of a dogma. Nat Rev Neurosci 1:67-73
16. Guan J, Bennet L, George S, Wu D, Waldvogel HJ, Gluckman PD, Faull RL, Crosier PS, Gunn AJ (2001) Insulin-like growth factor-1 reduces postischemic white matter injury in fetal sheep. J Cereb Blood Flow Metab 21:493-502 (Pubitemid 32422869)
17. Herzog CD, Dass B, Gasmi M, Bakay R, Stansell JE, Tuszynski M, Bankiewicz K, Chen EY, Chu Y, Bishop K, Kordower JH, Bartus RT (2008) Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Mol Ther 16:1737-1744
18. Leinninger GM, Feldman EL (2005) Insulin-like growth factors in the treatment of neurological disease. Endocr Dev 9:135-159
19. Liu XF, Fawcett JR, Thorne RG, DeFor TA, Frey II WH (2001) Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage. J Neurol Sci 187:91-97
20. Loddick SA, Liu XJ, Lu ZX, Liu C, Behan DP, Chalmers DC, Foster AC, Vale WW, Ling N, De Souza EB (1998) Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke. Proc Natl Acad Sci USA 95:1894-1898 (Pubitemid 28103490)
21. Lopez-Lopez C, LeRoith D, Torres-Aleman I (2004) Insulin-like growth factor I is required for vessel remodeling in the adult brain. Proc Natl Acad Sci USA 101:9833-9838 (Pubitemid 38869322)
22. Mackay KB, Loddick SA, Naeve GS, Vana AM, Verge GM, Foster AC (2003) Neuroprotective effects of insulinlike growth factor-binding protein ligand inhibitors in vitro and in vivo. J Cereb Blood Flow Metab 23:1160-1167
23. Matsumori Y, Hong SM, Fan Y, Kayama T, Hsu CY, Weinstein PR, Liu J (2006) Enriched environment and spatial learning enhance hippocampal neurogenesis and salvages ischemic penumbra after focal cerebral ischemia. Neurobiol Dis 22:187-198
24. Ohab JJ, Fleming S, Blesch A, Carmichael ST (2006) A neurovascular niche for neurogenesis after stroke. J Neurosci 26:13007-13016
25. Schabitz WR, Hoffmann TT, Heiland S, Kollmar R, Bardutzky J, Sommer C, Schwab S (2001) Delayed neuroprotective effect of insulin-like growth factor-i after experimental transient focal cerebral ischemia monitored with MRI. Stroke 32:1226-1233 (Pubitemid 32825815)
26. Shen F, Su H, Fan Y, Chen Y, Zhu Y, Liu W, Young WL, Yang GY (2006) Adeno-associated viral vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Stroke 37:2601-2606 (Pubitemid 44454685)
27. Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A, Greenberg DA (2003) VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest 111:1843-1851 (Pubitemid 38057729)
28. Wei L, Boyle MP, Yu SP (2001) Roles of VEGF in angiogenesis and functional recovery after a focal cerebral ischemia in mice. J Cereb Blood Flow Metab 21:S315
29. Zhu W, Fan Y, Frenzel T, Gasmi M, Bartus RT, Young WL, Yang GY, Chen Y (2008) Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice. Stroke 39:1254-1261