Randomized, placebo-controlled, crossover study of methylphenidate for attention-deficit/hyperactivity disorder symptoms in preschoolers with developmental disorders

Journal of Child and Adolescent Psychopharmacology

Volumn 19, Issue 4, 2009, Pages 329-339

  Ghuman, Jaswinder K ^a   Aman, Michael G ^b   Lecavalier, Luc ^b   Riddle, Mark A ^c   Gelenberg, Alan ^a,e   Wright, Ron ^a   Rice, Sydney ^d   Ghuman, Harinder S ^a   Fort, Carolyn ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^e Healthcare Technology Systems Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMOXETINE; ATROPINE; CENTRAL STIMULANT AGENT; FLUTICASONE PROPIONATE; MELATONIN; METHYLPHENIDATE; PLACEBO; PREDNISONE; PSYCHOTROPIC AGENT; QUETIAPINE; SALBUTAMOL;

ADD ON THERAPY; ADULT; ANOREXIA; ANXIETY; ARTICLE; ASTHMA; ATTENTION DEFICIT DISORDER; AUTISM; BEHAVIOR THERAPY; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; COMPULSION; CONTROL GROUP; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CRYING; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; DYSPHORIA; FATIGUE; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; INTELLECTUAL IMPAIRMENT; IRRITABILITY; MALE; MENTAL INSTABILITY; MORNING DOSAGE; NOSE CONGESTION; OCCUPATIONAL THERAPY; OPTIMAL DRUG DOSE; OUTCOME ASSESSMENT; PHYSIOTHERAPY; PRESCHOOL CHILD; PSYCHOSOCIAL WITHDRAWAL; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS; SHORT COURSE THERAPY; SIDE EFFECT; SINGLE BLIND PROCEDURE; SLEEP DISORDER; SPEECH THERAPY; STEREOTYPY; TIC; TREATMENT DURATION; TREATMENT RESPONSE;

AGE FACTORS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; METHYLPHENIDATE; SINGLE-BLIND METHOD;

EID: 69549087898     PISSN: 10445463     EISSN: None     Source Type: Journal    
DOI: 10.1089/cap.2008.0137     Document Type: Article

References (44)

1. AACAP: Practice parameters for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 46:894-921, 2007.
2. Aman MG, Van Bourgondien ME, Wolford PL, Sarphare G: Psychotropic and anticonvulsant drugs in subjects with autism: Prevalence and patterns of use. J Am Acad Child Adolesc Psychiatry 34:1672-1681, 1995.
3. Aman MG, Tasse MJ, Rojahn J, Hammer D: The Nisonger CBRF: A child behavior rating form for children with developmental disabilities. Res Dev Disabil 17:41-57, 1996. (Pubitemid 26030823)
4. Aman MG, Buican B, Arnold LE: Methylphenidate treatment in children with borderline IQ and mental retardation: Analysis of three aggregated studies. J Child Adolesc Psychopharmacol 13:29-40, 2003. (Pubitemid 36570186)
5. Aman MG, Lam KS, Van Bourgondien ME: Medication patterns in patients with autism: Temporal, regional, and demographic influences. J Child Adolesc Psychopharmacol 15:116-126, 2005.
6. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (DSM-II). Washington (DC): American Psychiatric Association, 1968.
7. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Text Revision (DSM-IV-TR). Washington (DC): American Psychiatric Association, 2000.
8. Barkley RA, Edwards G: Diagnostic interview, behavior rating scales, and the medical examination. In: Attention-deficit hyperactivity disorder: A handbook for diagnosis and treatment. pp 263-293, NewYork: Guilford Press, 1998.
9. Bayley N: Bayley Scales of Infant Development. San Antonio (Texas): Psychological Corporation, 1993.
10. Birmaher B, Quintana H, Greenhill LL: Case study: Methylphenidate treatment of hyperactive autistic children. J American Acad Child Adolesc Psychiatry 27:248, 1988. (Pubitemid 18089217)
11. Campbell M, Fish B, David R, Shapiro T, Collins P, Koh C: Response to triiodothyronine and dextroamphetamine: A study of preschool schizophrenic children. J Autism Devel Disord 2:343-358, 1972.
12. Campbell M, Small AM, Collins PJ, Friedman E, David R, Genieser N: Levodopa and levoamphetamine: A crossover study in young schizophrenic children. Curr Ther Res Clin Exp 19:70-86, 1976.
13. Conners CK: Conners' Rating Scales-Revised (CRS-R): Technical Manual. North Tonawanda (New York): Multi-Health Systems, 2001.
14. Di Martino A, Melis G, Cianchetti C, Zuddas A: Methylphenidate for pervasive developmental disorders: Safety and efficacy of acute single dose test and ongoing therapy: An open-pilot study. J Child Adolesc Psychopharmacol 14:207-218, 2004. (Pubitemid 38988787)
15. Elia J, Borcherding BG, Rapoport JL, Keysor CS: Methylphenidate and dextroamphetamine treatments of hyperactivity: Are there true nonresponders? Psychiatry Res 36:141-155, 1991.
16. Elliott CD: Differential Ability Scales. The Psychological Corporation, Harcourt Brace Jovanovich, 1990.
17. Ghuman JK, Ginsburg GS, Subramaniam G, Ghuman HS, Kau ASM, Riddle MA: Psychostimulants in preschool children with attention-deficit/hyperactivity disorder: Clinical evidence from a developmental disorders institution. J Am Acad Child Adolesc Psychiatry 40:516, 2001. (Pubitemid 32374268)
18. Ghuman JK, Cataldo MD, Beck MH, Slifer KJ: Behavioral training for pill-swallowing difficulties in young children with autistic disorder. J Child Adolesc Psychopharmacol 14:601-611, 2004.
19. Ghuman JK, Riddle MA, Vitiello B, Greenhill LL, Chuang SZ, Wigal SB, Kollins SH, Abikoff HB, McCracken JT, Kastelic E: Comorbidity moderates response to methylphenidate in the preschoolers with Attention-deficit/hyperactivity disorder Treatment Study (PATS). J Child Adolesc Psychopharmacol 17:563-580, 2007. (Pubitemid 350058980)
20. Ghuman JK, Arnold LE, Anthony BJ: Diagnosis, psychopharmacological and other treatments in preschool children with ADHD: Current evidence and practice. J Child Adolesc Psychopharmacol 18:413-447, 2008.
21. Greenhill L, Kollins S, Abikoff H, McCracken J, Riddle M, Swanson J, McGough J, Wigal S, Wigal T, Vitiello B, Skrobala A, Posner K, Ghuman J, Cunningham C, Davies M, Chuang S, Cooper T: Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD. J Am Acad Child Adolesc Psychiatry 45:1284-1293, 2006. (Pubitemid 44665445)
22. Guy W: ECDEU Assessment Manual for Psychopharmacology (Revised). Washington (DC): Department of Health Education and Welfare, 1976.
23. Handen BL, Feldman HM, Lurier A, Murray PJ: Efficacy of methylphenidate among preschool children with developmental disabilities and ADHD. J Am Acad Child Adolesc Psychiatry 38:805-812, 1999. (Pubitemid 29309839)
24. Hilton A, Armstrong R: Stat note 6: Post hoc anova tests. Microbiologist 7:34-36, 2006.
25. Hollingshead AB: Four factor index of social status. Unpublished manuscript, New Haven (Connecticut), Yale University, 1975.
26. Hoshino Y, Kumashiro H, Kaneko M, Takahashi Y: The effects of methylphenidate on early infantile autism and its relation to serum serotonin levels. Psychiatry Clin Neurosci 31:605-614, 1977.
27. Lecavalier L: Behavioral and emotional problems in young people with pervasive developmental disorders: Relative prevalence, effects of subject characteristics, and empirical classification. J Autism Dev Disord 36:1101-1114, 2006.
28. Lord C, Rutter M, DiLavore P, Risi S: Autism Diagnostic Observation Schedule: ADOS: Manual. Los Angeles (California): Western Psychological Services, 2002.
29. Lowe TL, Cohen DJ, Detlor J, Kremenitzer MW, Shaywitz BA: Stimulant medications precipitate Tourette's syndrome. JAMA 247:1729-1731, 1982. (Pubitemid 12192968)
30. Mayes SD, Crites DL, Bixler EO, Humphrey FJ, 2nd, Mattison RE: Methylphenidate and ADHD: influence of age, IQ and neurodevelopmental status. Dev Med Child Neurol 36:1099-1107, 1994.
31. MTA: Moderators and mediators of treatment response for children with attention-deficit/hyperactivity disorder: The Multimodal Treatment Study of children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 56:1088-1096, 1999.
32. Oswald DP, Sonenklar NA: Medication use among children with autism spectrum disorders. J Child Adolesc Psychopharmacol 17:348-355, 2007. (Pubitemid 47067958)
33. Roffman JL, Raskin LA: Stereotyped behavior: Effects of d-amphetamine and methylphenidate in the young rat. Pharmacol Biochem Behav 58:1095-1102, 1997. (Pubitemid 28108221)
34. Rojahn J, Matlock ST, Tasse MJ: The stereotyped behavior scale: Psychometric properties and norms. Res Dev Disabil 21:437-454, 2000. (Pubitemid 30948756)
35. Rosenthal R, Rosnow RL, Rubin DB: Contrasts and effect sizes in behavioral research: A correlational approach. Cambridge University Press, 2000.
36. Rosner B: Nonparametric Methods. Fundamentals of Biostatistics. pp 359-384, 2006.
37. RUPP Autism Network: Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch Gen Psychiatry 62:1266-1274, 2005.
38. Rutter M, LeCouteur A, Lord C: Autism Diagnostic Interview-Revised (ADI-R). Los Angeles (California): Western Psychological Services, 2003.
39. Scahill L, McDougle CJ, Williams SK, Dimitropoulos A, Aman MG, McCracken JT, Tierney E, Arnold LE, Pegeen Cronin PD, Grados M: Children's Yale-Brown Obsessive Compulsive Scale Modified for Pervasive Developmental Disorders. J Am Acad Child Adolesc Psychiatry 45:1114, 2006. (Pubitemid 44343067)
40. Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H, Aluwahlia S: A children's global assessment scale (CGAS). Arch Gen Psychiatry 40:1228-1231, 1983.
41. Sparrow SS, Balla DA, Cicchetti DV, Doll EA: Vineland Adaptive Behavior Scales: Interview Edition, Survey Form Manual. American Guidance Service, 1984.
42. Spencer T, Biederman J, Wilens T, Harding M, O'Donnell D, Griffin S: Pharmacotherapy of attention-deficit hyperactivity disorder across the life cycle. J Am Acad Child Adolesc Psychiatry 35:409, 1996. (Pubitemid 126418605)
43. Storch EA, Murphy TK, Geffken GR, Sajid M, Allen P, Roberti JW, Goodman WK: Reliability and validity of the Yale Global Tic Severity Scale. Psycholog Assess 17:486, 2005. (Pubitemid 43098496)
44. Zimmerman IL, Steiner VG, Pond RE: Preschool Language Scale, (PLS-4) English Edition. San Antonio (Texas): The Psychological Corporation, 1992.