The feasibility of a single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease

BMC Palliative Care

Volumn 8, Issue , 2009, Pages

  Farquhar, Morag C ^a   Higginson, Irene J ^b   Fagan, Petrea ^c   Booth, Sara ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL RESEARCH; CLINICAL STUDY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DYSPNEA; FAST TRACK PRAGMATIC METHODOLOGY; FEASIBILITY STUDY; FEMALE; FOLLOW UP; HEALTH CARE PERSONNEL; HUMAN; MALE; METHODOLOGY; OUTCOME ASSESSMENT; PALLIATIVE THERAPY; PATIENT CARE; PERFORMANCE MEASUREMENT SYSTEM; PHASE 2 CLINICAL TRIAL; QUESTIONNAIRE; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

EID: 69449107960     PISSN: None     EISSN: 1472684X     Source Type: Journal    
DOI: 10.1186/1472-684X-8-9     Document Type: Article

References (43)

1. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. JP Solano B Gomes IJ Higginson, J Pain Symptom Manage 2006 31 1 58 69
2. Non-pharmacological intervention for breathlessness in lung cancer. J Corner H Plant R A'Hern C Bailey, Palliat Med 1996 10 299 305
3. Multicentre randomised control trial of nursing intervention for breathlessness in patients with lung cancer. M Bredin J Corner M Krishnasamy H Plant C Bailey R A'Hern, BMJ 1999 318 901 904
4. Breathlessness clinics within specialist palliative care settings can improve the quality of life and functional capacity of patients with lung cancer. J Hately V Laurence A Scott R Baker P Thomas, Palliat Med 2003 17 410 417
5. An evaluation of a physiotherapy led non-pharmacological breathlessness programme for patients with intrathoracic malignancy. S Connors S Graham T Peel, Palliat Med 2007 21 4 285 287
6. MRC, A framework for development and evaluation of RCTs for complex interventions to improve health London: MRC 2000
7. Improving research methodology in breathlessness: a meeting convened by the MRC Clinical Trials Unit and the Cicely Saunders Foundation. S Booth, Palliat Med 2006 20 3 219 220
8. Why are trials in palliative care so difficult? GE Grande CJ Todd, Palliat Med 2000 14 69 74
9. Study protocol: delayed intervention randomised controlled trial within the Medical Research Council (MRC) Framework to assess the effectiveness of a new palliative care service. IJ Higginson B Vivat E Silber T Saleem R Burman S Hart P Edmonds, BMC Palliat Care 2006 2 5 7
10. Randomised controlled trial of a new palliative care service: compliance, recruitment and completeness of follow-up. IJ Higginson S Hart R Burman E Silber T Saleem P Edmonds, BMC Palliat Care 2008 7 1 7
11. Evaluation of a palliative care service: problems and pitfalls. IR McWhinney MJ Bass D Donner, BMJ 1994 309 1340 1342
12. The dilemma of the control condition in experience-based cognitive and behavioural treatment research. T Hart JR Fann TA Novack, Neuropsychol Rehabil 2008 18 1 1 21
13. Breathlessness in cancer and chronic obstructive pulmonary disease: using a qualitative approach to describe the experience of patients and carers. S Booth S Silvester C Todd, J Palliat Support Care 2003 1 4 337 344
14. The impact of a breathlessness intervention service (BIS) on the lives of patients with intractable dyspnoea: a qualitative Phase I study. S Booth M Farquhar M Gysels C Bausewein IJ Higginson, J Palliat Support Care 2006 4 287 293
15. Breathing exercises for asthma. E Holloway FSF Ram, Cochrane Database Syst Rev 2004 1 CD001277
16. WHO handbook for reporting results of cancer treatment. World Health Organisation, Geneva: WHO; WHO offset publication No. 48 1979
17. A new short form individual quality of life measure (SEIQoL-DW): application in a cohort of individuals with HIV/AIDS. AM Hickey G Bury CA O'Boyle F Bradley FD O'Kelly W Shannon, BMJ 1996 313 29 33
18. A measure of quality of life for clinical trials in chronic lung disease. GH Guyatt LB Berman M Townsend SO Pugsley LW Chambers, Thorax 1987 42 773 778
19. The perception of breathlessness in asthma. JGW Burdon EF Juniper FE Killian FE Hargreave EJM Campbell, Am Rev Respir Dis 1982 126 825 828
20. The Hospital Anxiety and Depression Scale. AS Zigmond RP Snaith, Acta Psychiatr Scand 1983 67 361 370
21. Relatives of the impaired elderly: correlates of feelings of burden. SH Zarit KE Reever J Bach-Peterson, Gerontologist 1980 20 6 649 655
22. Measuring caregiving appraisal. MP Lawton MH Kleban M Moss M Rovine A Glicksman, J Gerontol 1989 44 3 61 71
23. Relief of incident dyspnea in palliative cancer patients: a pilot randomized, controlled trial comparing nebulized hydromorphone, systemic hydromorphone, and nebulized saline. M Charles L Reymond F Israel, J Pain Symptom Manage 2008 36 1 29 38
24. Seeking new methodology for palliative care research: challenging assumptions about studying people who are approaching the end of life. JB Hopkinson DNM Wright JL Corner, Palliat Med 2005 19 523 537
25. Recruiting patients into a primary care based study of palliative care: why is it so difficult? G Ewing M Rogers S Barclay J McCabe A Martin C Todd, Palliat Med 2004 18 452 459
26. Key challenges and ways forward in researching the "good death": qualitative in-depth interview and focus group study. M Kendall F Harris K Boyd A Sheikh SA Murray D Brown I Mallinson N Kearney A Worth, BMJ 2007 334 521 526
27. A survey of the views of palliative care healthcare professionals towards referring cancer patients to participate in randomized controlled trials in palliative care. C White K Gilshenan J Hardy, Support Care Cancer 2008 16 12 1397 1405
28. Randomised controlled trials of palliative care a survey of the views of advanced cancer patients and their relatives. CD White JR Hardy KS Gilshenan MA Charles CR Pinkerton, European Journal of Cancer Care 2008 44 13 1820 1828
29. Living with failing lungs: the doctor-patient relationship. SM Oliver, Fam Pract 2001 18 430 439
30. The last year of life of COPD: a qualitative study of symptoms and services. H Elkington P White J Addington-Hall R Higgs C Pettinari, Respir Med 2004 98 5 439 445
31. The healthcare needs of chronic obstructive pulmonary disease patients in the last year of life. H Elkington P White J Addington-Hall R Higgs P Edmonds, Palliat Med 2005 19 485 491
32. Palliative care assessment in chronic obstructive airways disease a needs assessment. J Skilbeck S Mott H Page D Smith S Hjelmeland-Ahmedzai D Clark, Palliat Med 1998 12 245 254
33. Palliative care in the community for cancer and end-stage cardiorespiratory disease: the views of patients, lay-carers and health care professionals. C Exley D Field L Jones T Stokes, Palliat Med 2005 19 76 83
34. Palliative care provision for patients with chronic obstructive pulmonary disease. AM Yohannes, Health Qual Life Outcomes 2007 5 17
35. Improving the palliative care of patients with intractable breathlessness. S Booth, MD thesis London; University of London 2009
36. The Australia-modified Karnofsky Performance Status (AKPS) Scale: a revised scale for contemporary palliative care clinical practice. A Abernethy T Shelby-James B Fazekas D Woods D Currow, BMC Palliat Care 2005 4 7
37. The use of nitrogen mustard in the palliative treatment of cancer. D Karnofsky W Abelmann L Craver J Burchenal, Cancer 1948 1 634 656
38. Performance status assessment in home hospice patients using a modified form of the Karnofsky Performance Status scale. S Nikoletti D Porock LJ Kristjanson K Medigovich P Pedler M Smith, J Palliat Med 2000 3 301
39. Repeated measurement of quality of life in palliative care research: the experience of using the SEIQoL-DW in a pilot phase II RCT of a complex intervention for breathlessness [abstract]. M Farquhar IJ Higginson S Booth, Palliat Med 2008 22 4 596
40. EuroQol-a new facility for the measurement of health-related quality of life. The EuroQol Group, Health Policy 1990 16 3 199 208
41. Living with COPD. A qualitative exploration of the experience of patients in Leeds. SJ Guthrie KM Hill MF Muers, Respir Med 2001 95 196 204
42. Interventions to manage symptoms at the end of life. CF Von Gunten, J Palliat Med 2005 8 s1 s-88
43. Recent developments in managing breathlessness: international researchers' meeting on Breathlessness in London, November 2006. C Bausewein F Malik S Booth IJ Higginson, Progress in Palliative Care 2007 15 6 279 284