Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins

Applied and Environmental Microbiology

Volumn 75, Issue 17, 2009, Pages 5451-5460

  Begley, Máire ^a,b,c   Cotter, Paul D ^a,c   Hill, Colin ^a,b   Ross, R Paul ^b,c  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c ANIMAL AND GRASSLAND RESEARCH AND INNOVATION CENTRE   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-MICROBIAL ACTIVITY; BACILLUS LICHENIFORMIS; BACTERIAL GENOMES; BIOINFORMATIC ANALYSIS; BIOSYNTHETIC ENZYMES; CLOSE PROXIMITY; GENES ENCODING; GENOME MINING; GEOBACILLUS THERMODENITRIFICANS; IN-SILICO SCREENING; LANTIBIOTICS; LISTERIA MONOCYTOGENES; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL GENOMES; POST-TRANSLATIONAL MODIFICATIONS; PROOF OF CONCEPT; STABLE STRUCTURES; STREPTOCOCCUS PNEUMONIAE; STRUCTURAL GENE; VANCOMYCIN-RESISTANT ENTEROCOCCI;

AMINES; BACTERIOLOGY; BIOINFORMATICS; ENCODING (SYMBOLS); GENES; MINING; PEPTIDES;

STRAIN;

LANM PROTEIN; LANTIBIOTIC; LICHENICIDIN; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTICS; ANTIMICROBIAL ACTIVITY; BACTERIUM; ENZYME ACTIVITY; GENE EXPRESSION; GENOME; HOST RANGE; IDENTIFICATION METHOD; PEPTIDE; PROTEIN;

ANABAENA VARIABILIS; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS LICHENIFORMIS; BIOINFORMATICS; BIOSYNTHESIS; COMPUTER MODEL; CONTROLLED STUDY; ENZYME SYNTHESIS; GENE SEQUENCE; GENE STRUCTURE; GENETIC CODE; GENOME; GEOBACILLUS; GEOBACILLUS THERMODENITRIFICAN; HERPETOSIPHON; HERPETOSIPHON AURANTIACUS; LISTERIA MONOCYTOGENES; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; STREPTOCOCCUS PNEUMONIAE; VANCOMYCIN RESISTANT ENTEROCOCCUS;

AMINO ACID SEQUENCE; BACILLUS; BACTERIOCINS; BIOSYNTHETIC PATHWAYS; COMPUTATIONAL BIOLOGY; ENTEROCOCCUS; GENE ORDER; GENES, BACTERIAL; GENOME, BACTERIAL; LISTERIA MONOCYTOGENES; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT;

ANABAENA VARIABILIS ATCC 29413; BACILLUS LICHENIFORMIS ATCC 14580; BACTERIA (MICROORGANISMS); ENTEROCOCCUS; GEOBACILLUS THERMODENITRIFICANS; HERPETOSIPHON AURANTIACUS ATCC 23779; LISTERIA MONOCYTOGENES; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 69449094338     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.00730-09     Document Type: Article

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