Effects of natamycin on sister chromatid exchanges, chromosome aberrations and micronucleus in human lymphocytes

Drug and Chemical Toxicology

Volumn 32, Issue 1, 2009, Pages 47-52

  Renczoullari, Eyyp ^a   Azirak, Sebile ^a   Canimoglu, Semir ^a   Parlak, Sebnem ^a   Buyukleyla, Mehmet ^a  

^a CUKUROVA UNIVERSITY   (Turkey)

Author keywords

Chromosome aberration; Human lymphocytes; Micronucleus; Natamycin; Sister chromatid exchange

Indexed keywords

NATAMYCIN; P 9703; UNCLASSIFIED DRUG; ANTIFUNGAL AGENT;

ARTICLE; CHROMOSOME ABERRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; MICRONUCLEUS; MITOSIS INDEX; NUCLEAR DIVISION; SISTER CHROMATID EXCHANGE; ADULT; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; MICRONUCLEUS TEST; TIME;

FUNGI;

ANTIFUNGAL AGENTS; CHROMOSOME ABERRATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; NATAMYCIN; SISTER CHROMATID EXCHANGE; TIME FACTORS; YOUNG ADULT;

EID: 69449088961     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540802431371     Document Type: Article

References (40)

1. Aguloglu S, Ortakaya C (1992). Eritromycin'in insan kromozomlari uzerine in vitro etkileri. XI. Ulusal Biyoloji Kongresi, Elaziǧ. Genel. Biyoloji 33-43.
2. Albertini RJ, Anderson D, Douglas GR, Hagmar L, Hemminki K, Merlo F et al. (2000). IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. Mutat. Res. 463, 111-172.
3. Amacher DE, Ellis JH Jr., Joyce AJ, Muehlbauer PA, Turner GN, Wahrenburg MG et al. (1993). Preclinical toxicology studies with azithromycin: genetic toxicology evaluation. Mutat. Res. 300, 79-90.
4. Aparicio JF, Fouces R, Mendes MV, Olivera N, Martin JF (2000). A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis. Chem. Biol. 7(11), 895-905.
5. Aparicio JF, Caffrey P, Gil JA, Zotchev SB (2003). Polyene antibiotic biosynthesis gene clusters. Appl. Microbiol. Biotechnol. 61, 179-188.
6. Armstrong MJ, Bean CL, Galloway SM (1992). A quantitative assessment of cytotoxicity associated with chromosomalaberration detection in Chinese hamster ovary cells. Mutat. Res. 265, 45-60.
7. Davidson PM, Doan CH (1993). Natamycin. In, Davidson DP, Branen AL eds. Antimicrobials in Foods (pp. 395-407). New York, Marcel Dekker.
8. Davidson PM (2001). Chemical preservatives and natural antimicrobial compounds. In, Doyle MP, Beuchat LR, Montville TJ eds. Food Microbiology: Fundamentals and Frontiers (pp. 593-627). Washington, DC, ASM Press.
9. Delves-Broughton J, Thomas LV, Williams G (2006). Natamycin as an antimycotic preservative on cheese and fermented sausages. Food Aust. 58, 19-21.
10. Epel D (1963). The effects of carbon monoxide inhibition of ATP level and the date of mitosis in sea urchin egg. J. Cell Biol. 17, 315-319.
11. European Medicines Agency (EMEA). (1998). Committee for veterinary medicinal products Natamycin. The European Agency for the Evaluation Of Medicinal Products Veterinary Medicines Evaluation Unit. EMEA/MRL/342/98-FINAL.
12. Evans HJ (1984). Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagen tests. In, Kilbey BJ, Legator M, Nichols W, Ramel C eds. Handbook of Mutagenicity Test Procedures, 2nd ed (pp. 405-427). Amsterdam, Elsevier Sciences.
13. Fenech M (2000). The in vitro micronucleus technique. Mutat. Res. 455, 81-95.
14. Fisher PB, Bryson V, Schaffner CP (1978). Polyene macrolide antibiotic cytotoxicity and membrane permeability alterations. I. Comparative effects of four classes of polyene macrolides on mammalian cells. J. Cell Physiol. 97, 345-351.
15. Galloway SM, Miller JE, Armstrong MJ, Bean CL, Skopek TR, Nichols WW (1998). DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens. Mutat. Res. 400, 169-186.
16. Guo SQ, Yuan ZH (1985). Mutagenicity test of eight antibiotics with the Ames' method. Chin. J. Antibiot. 10, 56-59.
17. Hillard CA, Armstrong MJ, Bradt CI, Hill RB, Greenwood SK, Galloway SM (1998). Chromosome aberrations in vitro related to cytotoxicity of non-mutagenic chemicals and metabolic poisons. Environ. Mol. Mutagen. 31, 316-326.
18. Hirano E, Takeda U (1981). Evaluation of mutagenicity of miokamycin, a new macrolide antibiotic in the Ames Salmonella test and dominant lethal test. J. Antibiot. 34, 443-446.
19. Ila HB, Topaktas, M (1999). In vivo genotoxic effects of spiramycin in rat bone marrow cells. Cytologia 64, 277-283.
20. Isidori M, Lavorgana M, Nardelli A, Pascarella L, Parrella A (2005). Toxic and genotoxic evaluation of six antibiotics on non-target organisms. Sci. Total Environ. 346, 87-98.
21. Jain AK, Andsorbhoy RK (1988). Cytogenetical studies on the effects of some chlorinated pesticides. III. Concluding remarks. Cytologia 53, 427-436.
22. Kirkland DJ, Muller L (2000). Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds. Mutat. Res. 464, 137-147.
23. Kirsch-Volders M, Sofuni T, Aardemac M, Albertini S, Eastmond D, Fenech M et al. (2003). Report from the in vitro micronucleus assay working group. Mutat. Res. 540, 153-163.
24. Liang J, Lin J, Xu Z, Su W, Cen P (2007). Space-flight mutation of Streptomyces gilvosporeus for enhancing natamycin production. Chin. J. Chern. Eng. 15, 720-724.
25. Mace JML, Daskal Y, Wray W (1978). Scanning electron microscopy of chromosome aberrations. Mutat. Res. 52, 199-206.
26. Madle S, Beek B, Nowak C (1993). Zum verstandnis von chromosomenmutationstests an somazellen. [To understand the chromosome mutations in somatic cells.] In, Fahrig R ed. Mutationsforschung und Genetische Toxicologie [Mutation and Genetic Toxicology] (pp. 224-242). Germany, Wissenschaftliche Buchgesellschaft publisher, Darmstadt, Germany.
27. Malecha MA (2004). Fungal keratitis caused by Scopulariopsis brevicaulis treated successfully with natamycin. Cornea 23, 201-203.
28. Mitchell I deG, Dixon PA, Gilbert PJ, White DJ (1980). Mutagenicity of antibiotics in microbial assays. Problems of evaluation. Mutat. Res. 79, 91-105.
29. National Toxicology Program. (1988). NTP Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and B6C3F1 Mice (inhalation studies). Natl. Toxicol. Program Tech. Rep. Ser. 467, 1-379.
30. Paz-y-Mino C, Bustamante G, Sanchez ME, Leone PE (2002). Cytogenetic monitoring in a population occupationally exposed to pesticides in Ecuador. Environ. Health Perspect. 110, 1077-1080.
31. Perry PE, Thompson EJ (1984). The methodology of sister chromatid exchanges. In, Kilbey BJ, Legator M, Nichols W, Ramel C eds. Handbook of Mutagenicity Test Procedures, 2nd ed (pp. 495-529). Amsterdam, Elsevier Sciences.
32. Prajna NV, Rao RA, Mathen MM, Prajna L, George C, Srinivasan M (2002). Simultaneous bilateral fungal keratitis caused by different fungi, Ind. J. Ophthalmol. 50(3), 213-214.
33. Rencuzoǧullari E, Ila HB, Topaktas M, Kayraldiz A, Budak S, Arslan M (2002). No significant increase in chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with spiramycin. Teratog. Carcinog. Mutagen. 22, 51-58.
34. Rencuzoǧullari E, Parlak S, Ila HB (2008). The effects of food protector biphenyl on sister chromatid exchange, chromosome aberrations, and micronucleus in human lymphocyte. Drug Chem. Toxicol. 31, 263-274.
35. Schnurer J, Magnusson J (2007). Antifungal lactic acid bacteria as biopreservatives. Trends Food Sci. Tech. 16, 70-78.
36. Sono A, Oyaide K, Suzuki A, Kobayashi Y, Matsumoto K, Yamamoto H (1989). Mutagenicity studies of miporamycin. Jpn. J. Antibiot. 42, 2506-2512.
37. Speit G, Haupter S (1985). On the mechanisms of differential giemsa staining of bromodeoxyuridine-substituted chromosomes. II. Differences between the demonstration of sister chromatid differentiation and replication patterns. Hum. Genet. 70, 126-129.
38. Thomas AH (1976). Analysis and assay of polyene antifungal antibiotics. Analyst 101, 321-339.
39. Vock EH, Lutz WK, Hormes P, Hoffmann HD, V amvakas S (1998). Discrimination between genotoxicity and cytotoxicity in the induction of DNA double-strand breaks in cells treated with etoposide, melphalan, cisplatin, potassium cyanide, Triton X-100, and -irradiation. Mutat. Res. 413, 83-94.
40. WHO. (2002). Safety evaluation of certain food additives and contaminants, natamycin (pimaricin). WHO Food Additives Series No. 48, 1-26.