Hypersensitivity to cisplatin after hRev3 mRNA knockdown in head and neck squamous cell carcinoma cells

Molecular Medicine Reports

Volumn 1, Issue 5, 2008, Pages 695-698

  Adachi, Makoto ^a   Ijichi, Kei ^a,b   Hasegawa, Yasuhisa ^a   Ogawa, Tetsuya ^a   Nakamura, Hideaki ^a   Yasui, Yoshihiro ^a   Fukushima, Masakazu ^c   Ishizaki, Kanji ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Cisplatin sensitivity; DNA polymerase ; Head and neck squamous cell carcinoma; Rev3 gene; siRNA

Indexed keywords

CISPLATIN; DNA POLYMERASE; MESSENGER RNA; SMALL INTERFERING RNA;

ARTICLE; CARCINOMA CELL; CATALYSIS; CELL ISOLATION; CONTROLLED STUDY; DNA SYNTHESIS; GENE EXPRESSION; HEAD AND NECK CARCINOMA; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERSENSITIVITY; POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA;

EID: 69449083318     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr_00000015     Document Type: Article

References (11)

1. Bourhis J: New approaches to enhance chemotherapy in SCCHN. Ann Oncol 16 (Suppl 6): vi20-vi24, 2005.
2. Aoki K, Ogawa T, Ito Y and Nakashima S: Cisplatin activates survival signals in UM-SCC-23 squamous cell carcinoma and these signal pathways are amplified in cisplatin-resistant squamous cell carcinoma. Oncol Rep 11: 375-379, 2004.
3. Cullen KJ, Newkirk KA, Schumaker LM, Aldosari N, Rone JD and Haddad BR: Glutathione S-transferase pi amplification is associated with cisplatin resistance in head and neck squamous cell carcinoma cell lines and primary tumors. Cancer Res 63: 8097-8102, 2003. (Pubitemid 37549452)
4. Siddik ZH: Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22: 7265-7279, 2003.
5. Ho YP, Au-Yeung SC and To KK: Platinum-based anticancer agents: innovative design strategies and biological perspectives. Med Res Rev 23: 633-655, 2003. (Pubitemid 37038095)
6. Lawrence CW and Maher VM: Eukaryotic mutagenesis and translesion replication dependent on DNA polymerase zeta and Rev1 protein. Biochem Soc Trans 29: 187-191, 2001.
7. Gibbs PE, McGregor WG, Maher VM, Nisson P and Lawrence CW: A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta. Proc Natl Acad Sci USA 95: 6876-6880, 1998.
8. Vaisman A, Lim SE, Patrick SM, Copeland WC, Hinkle DC, Turchi JJ and Chaney SG: Effect of DNA polymerases and high mobility group protein 1 on the carrier ligand specificity for translesion synthesis past platinum-DNA adducts. Biochemistry 38: 11026-11039, 1999. (Pubitemid 129752903)
9. Wu F, Lin X, Okuda T and Howell SB: DNA polymerase zeta regulates cisplatin cytotoxicity, mutagenicity, and the rate of development of cisplatin resistance. Cancer Res 64: 8029-8035, 2004. (Pubitemid 39446939)
10. Zander L and Bemark M: Immortalized mouse cell lines that lack a functional Rev3 gene are hypersensitive to UV irradiation and cisplatin treatment. DNA Repair (Amst) 3: 743-752, 2004. (Pubitemid 38716103)
11. Esposito G, Godindagger I, Klein U, Yaspo ML, Cumano A and Rajewsky K: Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality. Curr Biol 10: 1221-1224, 2000. (Pubitemid 30816686)