메뉴 건너뛰기




Volumn 36, Issue 10, 2004, Pages 1045-1051

The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; CASPASE RECRUITMENT DOMAIN PROTEIN 15;

EID: 6944252244     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1433     Document Type: Review
Times cited : (132)

References (100)
  • 1
    • 0642349115 scopus 로고    scopus 로고
    • Breakthrough of the year: The runners-up
    • Anonymous. Breakthrough of the year: The runners-up. Science 302, 2039-2045 (2003).
    • (2003) Science , vol.302 , pp. 2039-2045
  • 2
    • 0013375948 scopus 로고    scopus 로고
    • Neuregulin 1 and susceptibility to schizophrenia
    • Stefansson, H. et al. Neuregulin 1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71, 877-892 (2002).
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 877-892
    • Stefansson, H.1
  • 3
    • 0141819194 scopus 로고    scopus 로고
    • The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
    • Gretarsdottir, S. et al. The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat. Genet. 35, 131-138 (2003).
    • (2003) Nat. Genet. , vol.35 , pp. 131-138
    • Gretarsdottir, S.1
  • 4
    • 4243129131 scopus 로고    scopus 로고
    • Linkage of osteoporosis to chromosome 20p12 and association to BMP2
    • Styrkarsdottir, U. et al. Linkage of osteoporosis to chromosome 20p12 and association to BMP2. PLoS Biol. 1, E69 (2003).
    • (2003) PLoS Biol. , vol.1
    • Styrkarsdottir, U.1
  • 5
    • 10744220794 scopus 로고    scopus 로고
    • The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
    • Helgadottir, A. et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat. Genet. 36, 233-239 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 233-239
    • Helgadottir, A.1
  • 7
    • 0004247927 scopus 로고
    • JA Barth, Leipzig, reprinted by Arno, New York
    • Kraepelin, E. Psychiatrie (JA Barth, Leipzig, 1896; reprinted by Arno, New York, 1976).
    • (1896) Psychiatrie
    • Kraepelin, E.1
  • 9
    • 0000606592 scopus 로고
    • The genetic theory of schizophrenia: An analysis of 691 schizophrenia twin index families
    • Kallman, F.J. The genetic theory of schizophrenia: an analysis of 691 schizophrenia twin index families. Am. J. Psychiatry 103, 309-322 (1946).
    • (1946) Am. J. Psychiatry , vol.103 , pp. 309-322
    • Kallman, F.J.1
  • 10
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies
    • Sullivan, P.F., Kendler, K.S. & Neale, M.C. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch. Gen. Psychiatry 60, 1187-1192 (2003).
    • (2003) Arch. Gen. Psychiatry , vol.60 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 12
    • 0021047667 scopus 로고
    • The transmission of schizophrenia under a multifactorial threshold model
    • McGue, M., Gottesman, II & Rao, D.C. The transmission of schizophrenia under a multifactorial threshold model. Am. J. Hum. Genet. 35, 1161-1178 (1983).
    • (1983) Am. J. Hum. Genet. , vol.35 , pp. 1161-1178
    • McGue, M.1    Gottesman, I.I.2    Rao, D.C.3
  • 13
    • 2842562356 scopus 로고
    • Schizophrenia
    • (eds. King, R.A., Rotter, J.I. & Motulsky, A.G.) (Oxford University Press, Oxford)
    • st edn. (eds. King, R.A., Rotter, J.I. & Motulsky, A.G.) 816-836 (Oxford University Press, Oxford, 1992).
    • (1992) st Edn. , pp. 816-836
    • Hanson, D.L.1    Gottesman, I.I.2
  • 14
    • 0025019555 scopus 로고
    • Linkage strategies for genetically complex traits. I. Multilocus models
    • Risch, N. Linkage strategies for genetically complex traits. I. Multilocus models. Am. J. Hum. Genet. 46, 222-228 (1990).
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 222-228
    • Risch, N.1
  • 15
    • 0025008677 scopus 로고
    • Linkage strategies for genetically complex traits. II. The power of affected relative pairs
    • Risch, N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am. J. Hum. Genet. 46, 229-241 (1990).
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 229-241
    • Risch, N.1
  • 16
    • 0019302053 scopus 로고
    • Construction of a genetic linkage map in man using restriction fragment length polymorphisms
    • Botstein, D., White R.L., Skolnick M., & Davis R.W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32, 314-331 (1980).
    • (1980) Am. J. Hum. Genet. , vol.32 , pp. 314-331
    • Botstein, D.1    White, R.L.2    Skolnick, M.3    Davis, R.W.4
  • 17
    • 0021028244 scopus 로고
    • A polymorphic DNA marker genetically linked to Huntington's disease
    • Gusella, J.F. et al. A polymorphic DNA marker genetically linked to Huntington's disease. Nature 306, 234-238 (1983).
    • (1983) Nature , vol.306 , pp. 234-238
    • Gusella, J.F.1
  • 18
    • 0024453308 scopus 로고
    • Identification of the cystic fibrosis gene: Chromosome walking and jumping
    • Rommens, J.M. et al. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 245, 1059-1065 (1989).
    • (1989) Science , vol.245 , pp. 1059-1065
    • Rommens, J.M.1
  • 19
    • 0024424270 scopus 로고
    • Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
    • Riordan, J.R. et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245, 1066-1073 (1989).
    • (1989) Science , vol.245 , pp. 1066-1073
    • Riordan, J.R.1
  • 20
    • 0024423668 scopus 로고
    • Identification of the cystic fibrosis gene: Genetic analysis
    • Kerem, B. et al. Identification of the cystic fibrosis gene: genetic analysis. Science 245, 1073-1080 (1989).
    • (1989) Science , vol.245 , pp. 1073-1080
    • Kerem, B.1
  • 21
    • 0026949420 scopus 로고
    • Linkage disequilibrium mapping in isolated founder populations: Diastrophic dysplasia in Finland
    • Hastbacka, J. et at. Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland. Nat. Genet. 2, 204-211 (1992).
    • (1992) Nat. Genet. , vol.2 , pp. 204-211
    • Hastbacka, J.1
  • 22
    • 0023146964 scopus 로고
    • Genetic linkage between X-chromosome markers and bipolar affective illness
    • Baron, M. et al. Genetic linkage between X-chromosome markers and bipolar affective illness. Nature 326, 289-292 (1987).
    • (1987) Nature , vol.326 , pp. 289-292
    • Baron, M.1
  • 23
    • 0023091644 scopus 로고
    • Bipolar affective disorders linked to DNA markers on chromosome 11
    • Egeland, J.A. et al. Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325, 783-787 (1987).
    • (1987) Nature , vol.325 , pp. 783-787
    • Egeland, J.A.1
  • 24
    • 0023103748 scopus 로고
    • The genetic defect causing familial Alzheimer's disease maps on chromosome 21
    • St George-Hyslop, P.H. et al. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 235, 885-890 (1987).
    • (1987) Science , vol.235 , pp. 885-890
    • St. George-Hyslop, P.H.1
  • 25
    • 0024437794 scopus 로고
    • Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish
    • Kelsoe, J.R. et al. Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 342, 238-243 (1989).
    • (1989) Nature , vol.342 , pp. 238-243
    • Kelsoe, J.R.1
  • 26
    • 0027509066 scopus 로고
    • Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees
    • Baron, M. et al. Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Nat. Genet. 3, 49-55 (1993).
    • (1993) Nat. Genet. , vol.3 , pp. 49-55
    • Baron, M.1
  • 27
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch, N. & Merikangas, K. The future of genetic studies of complex human diseases. Science 273, 1516-1517 (1996).
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 28
    • 0029945706 scopus 로고    scopus 로고
    • Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker-sharing statistics
    • Sobel, E. & Lange, K. Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am. J. Hum. Genet. 58, 1323-1337 (1996).
    • (1996) Am. J. Hum. Genet. , vol.58 , pp. 1323-1337
    • Sobel, E.1    Lange, K.2
  • 30
    • 18244401676 scopus 로고    scopus 로고
    • Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31
    • Gudmundsson, G. et al. Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31. Am. J. Hum. Genet. 70, 586-592 (2002).
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 586-592
    • Gudmundsson, G.1
  • 31
    • 18244401151 scopus 로고    scopus 로고
    • Localization of a susceptibility gene for common forms of stroke to 5q12
    • Gretarsdottir, S. et al. Localization of a susceptibility gene for common forms of stroke to 5q12. Am. J. Hum. Genet. 70, 593-603 (2002).
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 593-603
    • Gretarsdottir, S.1
  • 32
    • 0036278330 scopus 로고    scopus 로고
    • Linkage of essential hypertension to chromosome 18q
    • Kristjansson, K. et al. Linkage of essential hypertension to chromosome 18q. Hypertension 39, 1044-1049 (2002).
    • (2002) Hypertension , vol.39 , pp. 1044-1049
    • Kristjansson, K.1
  • 33
    • 0346554974 scopus 로고    scopus 로고
    • A major susceptibility gene for asthma maps to chromosome 14q24
    • Hakonarson, H. et al. A major susceptibility gene for asthma maps to chromosome 14q24. Am. J. Hum. Genet. 71, 483-491 (2002).
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 483-491
    • Hakonarson, H.1
  • 34
    • 0037219893 scopus 로고    scopus 로고
    • A susceptibility gene for psoriatic arthritis maps to chromosome 16q: Evidence for imprinting
    • Karason, A. et al. A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting. Am. J. Hum. Genet. 72, 125-131 (2003).
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 125-131
    • Karason, A.1
  • 35
    • 0037730142 scopus 로고    scopus 로고
    • Anxiety with panic disorder linked to chromosome 9q in Iceland
    • Thorgeirsson, T.E. et al. Anxiety with panic disorder linked to chromosome 9q in Iceland. Am. J. Hum. Genet. 72, 1221-1230 (2003).
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 1221-1230
    • Thorgeirsson, T.E.1
  • 36
    • 0038353737 scopus 로고    scopus 로고
    • Genomewide scan for hand osteoarthritis: A novel mutation in matrilin-3
    • Stefansson, S.E. et al. Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3. Am. J. Hum. Genet. 72, 1448-1459 (2003).
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 1448-1459
    • Stefansson, S.E.1
  • 37
    • 0042666793 scopus 로고    scopus 로고
    • Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2
    • Reynisdottir, I. et al. Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2. Am. J. Hum. Genet. 73, 323-335 (2003).
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 323-335
    • Reynisdottir, I.1
  • 38
    • 0242439277 scopus 로고    scopus 로고
    • Localization of a gene for migraine without aura to chromosome 4q21
    • Bjornsson, A. et al. Localization of a gene for migraine without aura to chromosome 4q21. Am. J. Hum. Genet. 73, 986-993 (2003).
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 986-993
    • Bjornsson, A.1
  • 39
    • 0043048571 scopus 로고
    • Sequential tests for the detection of linkage
    • Morton, N.E. Sequential tests for the detection of linkage. Am. J. Hum. Genet. 7, 277-318 (1955).
    • (1955) Am. J. Hum. Genet. , vol.7 , pp. 277-318
    • Morton, N.E.1
  • 40
    • 0003408936 scopus 로고    scopus 로고
    • Johns Hopkins University Press, Baltimore
    • rd edn. (Johns Hopkins University Press, Baltimore, 1999).
    • (1999) rd Edn.
    • Ott, J.1
  • 41
    • 0012341558 scopus 로고
    • The mapping of human chromosomes
    • Renwick, J.H. The mapping of human chromosomes. Annu. Rev. Genet. 5, 81-120 (1971).
    • (1971) Annu. Rev. Genet. , vol.5 , pp. 81-120
    • Renwick, J.H.1
  • 42
    • 0016639309 scopus 로고
    • The prior probability of autosomal linkage
    • Elston, R.C. The prior probability of autosomal linkage. Ann. Hum. Genet. 38, 341-350 (1975).
    • (1975) Ann. Hum. Genet. , vol.38 , pp. 341-350
    • Elston, R.C.1
  • 43
    • 0027487931 scopus 로고
    • Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent
    • Feingold, E., Brown, P.O. & Siegmund, D. Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent. Am. J. Hum. Genet. 53, 234-251 (1993).
    • (1993) Am. J. Hum. Genet. , vol.53 , pp. 234-251
    • Feingold, E.1    Brown, P.O.2    Siegmund, D.3
  • 44
    • 0029061838 scopus 로고
    • Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent
    • Dupuis, J., Brown, P.O. & Siegmund, D. Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent. Genetics 140, 843-856 (1995).
    • (1995) Genetics , vol.140 , pp. 843-856
    • Dupuis, J.1    Brown, P.O.2    Siegmund, D.3
  • 45
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11, 241-247 (1995).
    • (1995) Nat. Genet. , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 47
    • 0037414862 scopus 로고    scopus 로고
    • Synthesis of serotonin by a second tryptophan hydroxylase isoform
    • Walther, D.J. et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299, 76 (2003).
    • (2003) Science , vol.299 , pp. 76
    • Walther, D.J.1
  • 48
    • 1642295096 scopus 로고    scopus 로고
    • Assessing the probability that a positive report is false: An approach for molecular epidemiology studies
    • Wacholder, S., Chanock, S., Garcia-Closas, M., El Ghormli, L. & Rothman, N. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J. Natl. Cancer Inst. 96, 434-442 (2004).
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 434-442
    • Wacholder, S.1    Chanock, S.2    Garcia-Closas, M.3    El Ghormli, L.4    Rothman, N.5
  • 49
    • 1642399172 scopus 로고    scopus 로고
    • Betting odds and genetic associations
    • Thomas, D.C. & Clayton, D.G. Betting odds and genetic associations. J. Natl. Cancer Inst. 96, 421-423 (2004).
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 421-423
    • Thomas, D.C.1    Clayton, D.G.2
  • 50
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • The International HapMap Consortium. The International HapMap Project. Nature 426, 789-796 (2003).
    • (2003) Nature , vol.426 , pp. 789-796
  • 51
    • 2342615572 scopus 로고    scopus 로고
    • Positional cloning by linkage disequilibrium
    • Maniatis, N. et al. Positional cloning by linkage disequilibrium. Am. J. Hum. Genet. 74, 846-855 (2004).
    • (2004) Am. J. Hum. Genet. , vol.74 , pp. 846-855
    • Maniatis, N.1
  • 52
    • 0037373275 scopus 로고    scopus 로고
    • Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease
    • Botstein, D. & Risch, N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat. Genet. 33 Suppl, 228-237 (2003).
    • (2003) Nat. Genet. , vol.33 , Issue.SUPPL. , pp. 228-237
    • Botstein, D.1    Risch, N.2
  • 53
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Society B 57, 289-300 (1995).
    • (1995) J. R. Stat. Society B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 54
    • 3743109290 scopus 로고    scopus 로고
    • A new approach to the problem of multiple comparisons in the genetic dissection of complex traits
    • Weller, J.I., Song, J.Z., Heyen, D.W., Lewin, H.A. & Ron, M. A new approach to the problem of multiple comparisons in the genetic dissection of complex traits. Genetics 150, 1699-1706 (1998).
    • (1998) Genetics , vol.150 , pp. 1699-1706
    • Weller, J.I.1    Song, J.Z.2    Heyen, D.W.3    Lewin, H.A.4    Ron, M.5
  • 55
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey, J.D. & Tibshirani, R. Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. USA 100, 9440-9445 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 56
    • 0037786658 scopus 로고    scopus 로고
    • False discovery rate in linkage and association genome screens for complex disorders
    • Sabatti, C., Service, S. & Freimer, N. False discovery rate in linkage and association genome screens for complex disorders. Genetics 164, 829-833 (2003).
    • (2003) Genetics , vol.164 , pp. 829-833
    • Sabatti, C.1    Service, S.2    Freimer, N.3
  • 57
    • 0014655989 scopus 로고
    • Groups at risk in low birth weight infants and perinatal mortality
    • 193:1+
    • Rantakallio, P. Groups at risk in low birth weight infants and perinatal mortality. Acta. Paediatr. Scand. 193, 193:1+ (1969).
    • (1969) Acta. Paediatr. Scand. , vol.193
    • Rantakallio, P.1
  • 58
    • 0031403760 scopus 로고    scopus 로고
    • Ecological and individual predictors of birthweight in a northern Finland birth cohort 1986
    • Jarvelin, M.R. et al. Ecological and individual predictors of birthweight in a northern Finland birth cohort 1986. Paediatr. Perinat. Epidemiol. 11, 298-312 (1997).
    • (1997) Paediatr. Perinat. Epidemiol. , vol.11 , pp. 298-312
    • Jarvelin, M.R.1
  • 59
    • 0038670579 scopus 로고    scopus 로고
    • The human phenome project
    • Freimer, N. & Sabatti, C. The human phenome project. Nat. Genet. 34, 15-21 (2003).
    • (2003) Nat. Genet. , vol.34 , pp. 15-21
    • Freimer, N.1    Sabatti, C.2
  • 60
    • 0036607381 scopus 로고    scopus 로고
    • Association analysis of candidate genes for neuropsychiatric disease: The perpetual campaign
    • Glatt, C.E. & Freimer, N.B. Association analysis of candidate genes for neuropsychiatric disease: the perpetual campaign. Trends Genet. 18, 307-312 (2002).
    • (2002) Trends Genet. , vol.18 , pp. 307-312
    • Glatt, C.E.1    Freimer, N.B.2
  • 61
    • 0037135137 scopus 로고    scopus 로고
    • Serotonin transporter genetic variation and the response of the human amygdala
    • Hariri, A.R., et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 297, 400-403 (2002).
    • (2002) Science , vol.297 , pp. 400-403
    • Hariri, A.R.1
  • 62
    • 0037624040 scopus 로고    scopus 로고
    • Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
    • Caspi, A. et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386-389 (2003).
    • (2003) Science , vol.301 , pp. 386-389
    • Caspi, A.1
  • 64
    • 0347988064 scopus 로고    scopus 로고
    • A call for accurate phenotype definition in the study of complex disorders
    • Funalot, B., Varenne, O. & Mas, J.L. A call for accurate phenotype definition in the study of complex disorders. Nat. Genet. 36, 3 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 3
    • Funalot, B.1    Varenne, O.2    Mas, J.L.3
  • 65
    • 0347988064 scopus 로고    scopus 로고
    • Reply to "A call for accurate phenotype definition in the study of complex disorders."
    • Gulcher, J.R., Gretarsdottie, S., King, A. &. Stefansson, K. Reply to "A call for accurate phenotype definition in the study of complex disorders." Nat. Genet. 36, 3-4 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 3-4
    • Gulcher, J.R.1    Gretarsdottie, S.2    King, A.3    Stefansson, K.4
  • 66
    • 0033496277 scopus 로고    scopus 로고
    • Power of variance component linkage analysis to detect quantitative trait loci
    • Williams, J.T. & Blangero, J. Power of variance component linkage analysis to detect quantitative trait loci. Ann. Hum. Genet. 6, 545-563 (1999).
    • (1999) Ann. Hum. Genet. , vol.6 , pp. 545-563
    • Williams, J.T.1    Blangero, J.2
  • 67
    • 0035825219 scopus 로고    scopus 로고
    • Endophenotypes as quantitative risk factors for psychiatric disease: Rationale and study design
    • Almasy, L. & Blangero, J. Endophenotypes as quantitative risk factors for psychiatric disease: rationale and study design. Am. J. Med. Genet. 105, 42-44 (2001).
    • (2001) Am. J. Med. Genet. , vol.105 , pp. 42-44
    • Almasy, L.1    Blangero, J.2
  • 68
    • 18544381909 scopus 로고    scopus 로고
    • A high-resolution recombination map of the human genome
    • Kong, A. et al. A high-resolution recombination map of the human genome. Nat. Genet. 31, 241-247 (2002).
    • (2002) Nat. Genet. , vol.31 , pp. 241-247
    • Kong, A.1
  • 69
    • 0034098774 scopus 로고    scopus 로고
    • Allegro, a new computer program for multipoint linkage analysis
    • Gudbjartsson, D.F., Jonasson, K., Frigge, M.L. & Kong, A. Allegro, a new computer program for multipoint linkage analysis. Nat. Genet. 25, 12-13 (2000).
    • (2000) Nat. Genet. , vol.25 , pp. 12-13
    • Gudbjartsson, D.F.1    Jonasson, K.2    Frigge, M.L.3    Kong, A.4
  • 70
    • 0033364825 scopus 로고    scopus 로고
    • A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci
    • Hovatta, I. et al. A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am. J. Hum. Genet. 65, 1114-1124 (1999).
    • (1999) Am. J. Hum. Genet. , vol.65 , pp. 1114-1124
    • Hovatta, I.1
  • 71
    • 0033759713 scopus 로고    scopus 로고
    • A second-generation genomewide screen for asthma-susceptibility alleles in a founder population
    • Ober, C., Tsalenko, A., Parry, R. & Cox, N.J. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am. J. Hum. Genet. 67, 1154-1162 (2000).
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 1154-1162
    • Ober, C.1    Tsalenko, A.2    Parry, R.3    Cox, N.J.4
  • 72
    • 0035069310 scopus 로고    scopus 로고
    • Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method
    • Garner, C. et al. Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method. Am. J. Hum. Genet. 68, 1061-1064 (2001).
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 1061-1064
    • Garner, C.1
  • 73
    • 18544375780 scopus 로고    scopus 로고
    • Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24
    • Schoenberg, S.J. et al. Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24. Hum. Mol. Genet. 11, 2257-2267 (2002).
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2257-2267
    • Schoenberg, S.J.1
  • 74
    • 9144235671 scopus 로고    scopus 로고
    • Predisposition locus for major depression at chromosome 12q22-12q23.2
    • Abkevich, V. et al. Predisposition locus for major depression at chromosome 12q22-12q23.2. Am. J. Hum. Genet. 73, 1271-1281 (2003).
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 1271-1281
    • Abkevich, V.1
  • 75
    • 12144287883 scopus 로고    scopus 로고
    • Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1
    • Abecasis, G.R. et al. Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1. Am. J. Hum. Genet. 74, 403-417 (2004).
    • (2004) Am. J. Hum. Genet. , vol.74 , pp. 403-417
    • Abecasis, G.R.1
  • 76
    • 0038143616 scopus 로고    scopus 로고
    • Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica
    • Carvajal-Carmona, L.G. et al. Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica. Hum. Genet. 112, 534-541 (2003).
    • (2003) Hum. Genet. , vol.112 , pp. 534-541
    • Carvajal-Carmona, L.G.1
  • 78
    • 0037417254 scopus 로고    scopus 로고
    • Alzheimer's disease and Parkinson's disease
    • Nussbaum, R.L. & Ellis, C.E. Alzheimer's disease and Parkinson's disease N. Engl. J. Med. 348, 1356-1364 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1356-1364
    • Nussbaum, R.L.1    Ellis, C.E.2
  • 79
    • 0345530985 scopus 로고    scopus 로고
    • Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects
    • Hennah, W. et al. Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. Hum. Mol. Genet. 12, 3151-3159 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 3151-3159
    • Hennah, W.1
  • 80
    • 0029046177 scopus 로고
    • Complete multipoint sib-pair analysis of qualitative and quantitative traits
    • Kruglyak, L. & Lander, E.S. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am. J. Hum. Genet. 57, 439-454 (1995).
    • (1995) Am. J. Hum. Genet. , vol.57 , pp. 439-454
    • Kruglyak, L.1    Lander, E.S.2
  • 81
    • 0029886532 scopus 로고    scopus 로고
    • Parametric and non-parametric linkage analysis: A unified multipoint approach
    • Kruglyak, L., Daly, M.J., Reeve-Daly, M.P. & Lander, E.S. Parametric and non-parametric linkage analysis: a unified multipoint approach. Am. J. Hum. Genet. 58, 1347-1363 (1996).
    • (1996) Am. J. Hum. Genet. , vol.58 , pp. 1347-1363
    • Kruglyak, L.1    Daly, M.J.2    Reeve-Daly, M.P.3    Lander, E.S.4
  • 82
    • 13344259990 scopus 로고    scopus 로고
    • Mapping of a susceptibility locus for Crohn's disease on chromosome 16
    • Hugot, J.P. et al. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 379, 821-823 (1996).
    • (1996) Nature , vol.379 , pp. 821-823
    • Hugot, J.P.1
  • 83
    • 16044373177 scopus 로고    scopus 로고
    • Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12
    • Satsangi, J. et al. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat. Genet. 14, 199-202 (1996).
    • (1996) Nat. Genet. , vol.14 , pp. 199-202
    • Satsangi, J.1
  • 84
    • 13144261748 scopus 로고    scopus 로고
    • Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1
    • Cho, J.H. et al. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc. Natl. Acad. Sci. USA 95, 7502-7507 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7502-7507
    • Cho, J.H.1
  • 85
    • 0035004413 scopus 로고    scopus 로고
    • International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16
    • Cavanaugh, J. et al. International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16. Am. J. Hum. Genet. 68, 1165-1171 (2001).
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 1165-1171
    • Cavanaugh, J.1
  • 86
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot, J.P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603 (2001).
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1
  • 87
    • 0037389679 scopus 로고    scopus 로고
    • Screening the genome for rheumatoid arthritis susceptibility genes: A replication study and combined analysis of 512 multicase families
    • Jawaheer, D. et al. Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families. Arthritis Rheum. 48, 906-916 (2003).
    • (2003) Arthritis Rheum. , vol.48 , pp. 906-916
    • Jawaheer, D.1
  • 88
    • 0036188754 scopus 로고    scopus 로고
    • Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sib pairs in the United Kingdom
    • MacKay, K. et al. Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sib pairs in the United Kingdom. Arthritis Rheum. 46, 632-639 (2002).
    • (2002) Arthritis Rheum. , vol.46 , pp. 632-639
    • MacKay, K.1
  • 89
    • 0347364727 scopus 로고    scopus 로고
    • GenomEUtwin: A strategy to identify genetic influences on health and disease
    • Peltonen, L. GenomEUtwin: a strategy to identify genetic influences on health and disease. Twin Res. 6, 354-60 (2003).
    • (2003) Twin Res. , vol.6 , pp. 354-360
    • Peltonen, L.1
  • 90
    • 18544365654 scopus 로고    scopus 로고
    • Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate
    • Ophoff, R.A. et al. Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate. Am. J. Hum. Genet. 71, 565-574 (2002).
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 565-574
    • Ophoff, R.A.1
  • 91
    • 0036314246 scopus 로고    scopus 로고
    • A genome-wide search for linkage-disequilibrium with type 1 diabetes in a recent genetically isolated population from the Netherlands
    • Vaessen, N. et al. A genome-wide search for linkage-disequilibrium with type 1 diabetes in a recent genetically isolated population from the Netherlands. Diabetes 51, 856-859 (2002).
    • (2002) Diabetes , vol.51 , pp. 856-859
    • Vaessen, N.1
  • 93
    • 11144357144 scopus 로고    scopus 로고
    • Characterization of a common susceptibility locus for asthma-related traits
    • Laitinen, T. et al. Characterization of a common susceptibility locus for asthma-related traits. Science 304, 300-304 (2004).
    • (2004) Science , vol.304 , pp. 300-304
    • Laitinen, T.1
  • 95
    • 0031820439 scopus 로고    scopus 로고
    • APOE genotype predicts when-not whether-one is predisposed to develop Alzheimer disease
    • Meyer, M.R., et al. APOE genotype predicts when-not whether-one is predisposed to develop Alzheimer disease. Nat. Genet. 19, 321-322 (1998).
    • (1998) Nat. Genet. , vol.19 , pp. 321-322
    • Meyer, M.R.1
  • 96
    • 0037426289 scopus 로고    scopus 로고
    • The role of APOE-epsilon4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging
    • Bretsky, P. et al. The role of APOE-epsilon4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging. Neurology 60, 1077-1081 (2003).
    • (2003) Neurology , vol.60 , pp. 1077-1081
    • Bretsky, P.1
  • 97
    • 0034680078 scopus 로고    scopus 로고
    • Patterns of brain activation in people at risk for Alzheimer's disease
    • Bookheimer, S.Y. et al. Patterns of brain activation in people at risk for Alzheimer's disease. N. Engl. J. Med. 343, 450-456 (2000).
    • (2000) N. Engl. J. Med. , vol.343 , pp. 450-456
    • Bookheimer, S.Y.1
  • 98
    • 12944259210 scopus 로고    scopus 로고
    • Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease
    • Small, G.W. et al. Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proc. Natl. Acad. Sci. USA 97, 6037-6042 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6037-6042
    • Small, G.W.1
  • 99
    • 0030612497 scopus 로고    scopus 로고
    • Apolipoprotein e epsilon4 associated with chronic traumatic brain injury in boxing
    • Jordan, B.D. et al. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. JAMA 278, 136-140 (1997).
    • (1997) JAMA , vol.278 , pp. 136-140
    • Jordan, B.D.1
  • 100
    • 0033554880 scopus 로고    scopus 로고
    • Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury
    • Friedman, G. et al. Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury. Neurology 52, 244-248 (1999).
    • (1999) Neurology , vol.52 , pp. 244-248
    • Friedman, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.