Enhanced lymphocyte proliferation responses in pediatric patients early after myelosuppressive chemotherapy

Pediatric Blood and Cancer

Volumn 43, Issue 6, 2004, Pages 644-650

  Stachel, Daniel ^a,c   Fütterer, Agnes ^b   Haas, Rainer J ^b   Schmid, Irene ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Children; Enhanced immunity; Immune system; Lymphopenia induced (homeostatic) regeneration; Myelosuppressive chemotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARAGINASE; CALCIMYCIN; CALCIUM ION; CD11B ANTIGEN; CD28 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD56 ANTIGEN; CD57 ANTIGEN; CISPLATIN; CORTICOSTEROID; CYCLOSPORIN A; CYTARABINE; DACTINOMYCIN; DAUNORUBICIN; ETOPOSIDE; HLA DR ANTIGEN; IFOSFAMIDE; IMMUNOSUPPRESSIVE AGENT; METHOTREXATE; OKT 3; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOHEMAGGLUTININ; PREDNISOLONE; TENIPOSIDE; THYMIDINE; TRITIUM; VINCRISTINE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CALCIUM CELL LEVEL; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; CROSS LINKING; CYTOMEGALOVIRUS INFECTION; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; MONONUCLEAR CELL; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; WHOLE BODY RADIATION;

ANTIGENS, CD; BONE MARROW TRANSPLANTATION; CALCIMYCIN; CALCIUM; CELL PROLIFERATION; CHILD; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; IMMUNOSUPPRESSION; LYMPHOCYTES; MUROMONAB-CD3; MYELOID CELLS; PHYTOHEMAGGLUTININS; THYMIDINE; TIME FACTORS;

EID: 6944243924     PISSN: 15455009     EISSN: None     Source Type: Journal    
DOI: 10.1002/pbc.20140     Document Type: Article

References (38)

1. Foot AB, Potter MN, Donaldson C, et al. Immune reconstitution after BMT in children. Bone Marrow Transplant 1993;11:7-13.
2. Pizzo PA, Rubin M, Freifeld A, et al. The child with cancer and infection. II. Nonbacterial infections. J Pediatr 1991;119:845-857.
3. Brunvand MW, Collins C, Livingston RB, et al. Pneumocystis carinii pneumonia associated with profound lymphopenia and abnormal T-lymphocyte subset ratios during treatment for early-stage breast carcinoma. Cancer 1991;67:2407-2409.
4. Lehrnbecher T, Foster C, Vazquez N, et al. Therapy-induced alterations in host defense in children receiving therapy for cancer. J Pediatr Hematol Oncol 1997;19:399-417.
5. Mackall CL, Fleisher TA, Brown MR, et al. Lymphocyte depletion during treatment with intensive chemotherapy for cancer. Blood 1994;84:2221-2228.
6. Hakim FT, Cepeda R, Kaimei S, et al. Constraints on CD4 recovery postchemotherapy in adults: Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood 1997;90:3789-3798.
7. Mackall CL, Fleisher TA, Brown MR, et al. Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy. Blood 1997;89:3700-3707.
8. Heitger A, Winklehner P, Obexer P, et al. Defective T-helper cell function after T-cell-depleting therapy affecting naive and memory populations. Blood 2002;99:4053-4062.
9. Mackall CL, Fleisher TA, Brown MR, et al. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med 1995;332:143-149.
10. Kwak LW. Tumor vaccination strategies combined with autologous peripheral stem cell transplantation. Ann Oncol 1998;9(Suppl 1): S41-S46.
11. Borrello I, Sotomayor EM, Rattis FM, et al. Sustaining the graft-versus-tumor effect through posttransplant immunization with granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing tumor vaccines. Blood 2000;95:3011-3019.
12. Hu HM, Poehlein CH, Urba WJ, et al. Development of antitumor immune responses in reconstituted lymphopenic hosts. Cancer Res 2002;62:3914-3919.
13. Kwak LW, Campbell MJ, Zelenetz AD, et al. Combined syngeneic bone marrow transplantation and immunotherapy of a murine B-cell lymphoma: Active immunization with tumor-derived idiotypic immunoglobulin. Blood 1990;76:2411-2417.
14. Dummer W, Niethammer AG, Baccala R, et al. T cell homeostatic proliferation elicits effective antitumor autoimmunity. J Clin Invest 2002;110:185-192.
15. Pfizenmaier K, Jung H, Starzinski-Powitz A, et al. The role of T cells in anti-Herpes simplex virus immunity. I. Induction of antigen-specific cytotoxic T lymphocytes. J Immunol 1977;119:939-944.
16. Dudley ME, Wunderlich JR, Robbins PF, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 2002;298:850-854.
17. 2+ and membrane potential in lymphocytes. Nature 1982;295:68-71.
18. Vandenberghe PA, Ceuppens JL. Flow cytometric measurement of cytoplasmic free calcium in human peripheral blood T lymphocytes with fluo-3: A new fluorescent calcium indicator. J Immunol Methods 1990;127:197-205.
19. Handgretinger R, Leung W, Ihm K, et al. Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: The good news? Br J Cancer 2003;88:1874-1877.
20. Mastrangelo MJ, Berd D, Maguire H, Jr. The immunoaugmenting effects of cancer chemotherapeutic agents. Semin Oncol 1986;13:186-194.
21. Berko R, Seissman K, Colvin M, et al. Tumoricidal and immunomodulatory activities of drugs and implications for therapy of mice bearing a late stage MOPC-315 plasmacytoma. Int J Immunopharmacol 1988;10:825-834.
22. Gazit Z, Kedar E. Chemotherapy-induced modulation of natural killer and lymphokine-activated killer cell activity in euthymic and athymic mice. Cancer Immunol Immunother 1994;38:243-252.
23. Miles DW, Towlson KE, Graham R, et al. A randomised phase II study of sialyl-Tn and DETOX-B adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer. Br J Cancer 1996;74:1292-1296.
24. Bass KK, Mastrangelo MJ. Immunopotentiation with low-dose cyclophosphamide in the active specific immunotherapy of cancer. Cancer Immunol Immunother 1998;47:1-12.
25. Schluns KS, Kieper WC, Jameson SC, et al. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 2000;1:426-432.
26. Fry TJ, Mackall CL. Interleukin-7: Master regulator of peripheral T-cell homeostasis? Trends Immunol 2001;22:564-571.
27. Fry TJ, Connick E, Falloon J, et al. A potential role for interleukin-7 in T-cell homeostasis. Blood 2001;97:2983-2990.
28. Prlic M, Lefrancois L, Jameson SC. Multiple choices: Regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15. J Exp Med 2002;195:F49-F52.
29. Tan JT, Ernst B, Kieper WC, et al. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med 2002;195:1523-1532.
30. Dolstra H, Van de Wiel-van Kemenade E, De Witte T, et al. Clonal predominance of cytomegalovirus-specific CD8+ cytotoxic T lymphocytes in bone marrow recipients. Bone Marrow Transplant 1996;18:339-345.
31. Akbar AN, Terry L, Timms A, et al. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol 1988;140:2171-2178.
32. Atkinson K. T cell subpopulations defined by monoclonal antibodies after HLA-identical sibling marrow transplantation. II. Activated and functional subsets of helper-inducer and cytotoxic-suppressor subpopulations defined by two-colour fluorescence flow cytometry. Bone Marrow Transplant 1986;1:121-132.
33. Leino L, Lilius EM, Nikoskelainen J, et al. The reappearance of 10 differentiation antigens on peripheral blood lymphocytes after allogeneic bone marrow transplantation. Bone Marrow Transplant 1991;8:339-344.
34. Wursch AM, Gratama JW, Middeldorp JM, et al. The effect of cytomegalovirus infection on T lymphocytes after allogeneic bone marrow transplantation. Clin Exp Immunol 1985;62:278-287.
35. Gratama JW, Kardol M, Naipal AM, et al. The influence of cytomegalovirus carrier status on lymphocyte subsets and natural immunity. Clin Exp Immunol 1987;69:16-24.
36. Lenkei R, Andersson B. High correlations of anti-CMV titers with lymphocyte activation status and CD57 antibody-binding capacity as estimated with three-color, quantitative flow cytometry in blood donors. Clin Immunol Immunopathol 1995;77:131-138.
37. Wang EC, Moss PA, Frodsham P, et al. CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus. J Immunol 1995;155:5046-5056.
38. Mackall CL, Granger L, Sheard MA, et al. T-cell regeneration after bone marrow transplantation: Differential CD45 isoform expression on thymic-derived versus thymic-independent progeny. Blood 1993;82:2585-2594.