Evaluation of leptin, interleukin-1β, tumor necrosis factor-α and vascular endothelial growth factor in serum and follicular fluids of women undergoing controlled ovarian hyperstimulation as prognostic markers of ICSI outcome

In Vivo

Volumn 18, Issue 5, 2004, Pages 667-674

  Nikolettos, Nikos ^a,b   Asimakopoulos, Byron ^a   Nicolettos, Nikos ^b   Efthimiadou, Anna ^a   Mourvati, Efthemia ^a   Demirel, Cem ^c  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b Center for Repro Med of Thrace   (Greece)

^c ACIBADEM HOSPITAL   (Turkey)

Author keywords

ICSI; Interleukin; Leptin; Ovarian hyperstimulation; Tumor necrosis factor; Vascular endothelial growth factor

Indexed keywords

BIOCHEMICAL MARKER; CHORIONIC GONADOTROPIN; CYTOKINE; GONADORELIN AGONIST; HUMAN MENOPAUSAL GONADOTROPIN; INTERLEUKIN 1BETA; LEPTIN; RECOMBINANT FOLLITROPIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME IMMUNOASSAY; FEMALE; FERTILIZATION; HUMAN; HUMAN CELL; INFERTILITY THERAPY; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MALE; OOCYTE; OVARY FOLLICLE FLUID; OVARY HYPERSTIMULATION; PREGNANCY; PROGNOSIS; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

EID: 6944232197     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Barak V, Mordel N, Holzer H, Zajicek G, Treves AJ and Laufer N: The correlation of interleukin 1 and tumour necrosis factor to oestradiol, progesterone and testosterone levels in periovulatory follicular fluid of in vitro fertilization patients. Hum Reprod 7: 462-4, 1992.
2. Chen HF, Ho HN, Chen SU, Chao KH, Lin HR, Huang SC, Lee TY and Yang YS: Interleukin-1 beta (IL-1 beta) is increased in the follicular fluids of patients with premature luteinization. Am J Reprod Immunol 34: 356-362, 1995.
3. Geva E, Lessing JB, Lerner-Geva L, Azem F, Yovel I and Amit A: Elevated levels of interleukin-6 in the follicular fluid at the time of oocyte retrieval for in vitro fertilization may predict the development of early-form ovarian hyperstimulation syndrome. Fertil Steril 68: 133-137, 1997.
4. Lee A, Christenson LK, Stouffer RL, Burry KA and Patton PE: Vascular endothelial growth factor levels in serum and follicular fluid of patients undergoing in vitro fertilization. Fertil Steril 68 305-311, 1997.
5. Agrawal R, Sladkevicius P, Engmann L, Conway GS, Payne NN, Bekis J, Tan SL, Campbell S and Jacobs HS: Serum vascular endothelial growth factor concentrations and ovarian stromal blood flow are increased in women with polycystic ovaries. Hum Reprod 13: 651-655, 1998.
6. Anasti JN, Kalantaridou SN, Kimzey LM, George M and Nelson LM: Human follicle fluid vascular endothelial growth factor concentrations are correlated with luteinization in spontaneously developing follicles. Hum Reprod 13: 1144-7, 1998.
7. Artini PG, Fasciani A, Monti M, Luisi S, D'Ambrogio G and Genazzani AR: Changes in vascular endothelial growth factor levels and the risk of ovarian hyperstimulation syndrome in women enrolled in an in vitro fertilization program. Fertil Steril 70: 560-564, 1998.
8. Friedman CI, Seifer DB, Kennard EA, Arbogast L, Alak B and Danforth DR: Elevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential. Fertil Steril 70: 836-9, 1998.
9. Moncayo HE, Penz-Koza A, Marth C, Gastl G, Herold M and Moncayo, R: Vascular endothelial growth factor in serum and in the follicular fluid of patients undergoing hormonal stimulation for in-vitro fertilization. Hum Reprod 13: 3310-4, 1998.
10. Barroso G, Barrionuevo M, Rao P, Graham L, Danforth D, Huey S, Abuhamad A and Oehninger S: Vascular endothelial growth factor, nitric oxide, and leptin follicular fluid levels correlate negatively with embryo quality in IVF patients. Fertil Steril 72: 1024-1026, 1999.
11. Pellicer A, Albert C, Mercader A, Bonilla-Musoles F, Remohí J and Simòn C: The pathogenesis of ovarian hyperstimulation syndrome: in vivo studies investigating the role of interleukin-1β, interleukin-6, and vascular endothelial growth factor. Fertil Steril 71: 482-489, 1999a.
12. Pellicer A, Garrido N, Albert C, Navarro J, Remohí J and Simòn C: Cytokines in older patients undergoing in vitro fertilization: the relationship to the response to controlled ovarian hyperstimulation. J Assist Reprod Genet 16: 247-252, 1999b.
13. Lee KS, Joo BS, Na YJ, Yoon MS, Choi OH and Kim WW: Relationships between concentrations of tumor necrosis factor-α and nitric oxide in follicular fluid and oocyte quality. J Assist Reprod Genet 17: 222-228, 2000.
14. Mantzoros ChS, Cramer DW, Liberman RF and Barbieri RL: Predictive value of serum and follicular fluid leptin concentrations during assisted reproductive cycles in normal women and in women with the polycystic ovarian syndrome. Hum Reprod 15: 539-544, 2000.
15. Aboul Enien WM, Lewis-Jones ID and Vince GS: Follicular fluid cytokines and IVF outcome. Middle East Fertil Soc J 6: 206-211, 2001.
16. Brannian JD, Schmidt SM, Kreger DO and Hansen KA: Baseline non fasting serum leptin concentration to body mass index ratio is prespective of IVF outcomes. Hum Reprod 16: 1819-1826, 2001.
17. Tsai E-M, Yang C-H, Chen S-C, Liu Y-H, Chen H-S, Hsu S-C and Lee J-N: Leptin affects pregnancy outcome of in vitro fertilisation and steroidogenesis of human granulosa cells. J Assist Reprod Genet 19 169-176, 2002.
18. Amato G, Conte M, Mazziotti G, Lalli E, Vitolo G, Tucker AT, Bellastella A, Carella C and Izzo A: Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles. Obstet Gynecol 101: 1177-1182, 2003.
19. Asimakopoulos B, Schöpper B, Simopoulou M, Diedrich K, Al-Hasani S and Nikolettos N: Serum and follicular fluid cytokine and hormonal levels after ovarian stimulation. PhysPharm 2003, Odense, Denmark, Book of abstracts, p.45, 2003.
20. Nikolettos N, Asimakopoulos B, Schöpper B, Tentes I, Diedrich K and Al-Hasani S: Serum and follicular fluid hormonal and cytokine levels as markers of IVF outcome. Hum Reprod 18 (s1): 118, 2003.
21. Al-Hasani S, Küpker W, Baschat AA, Sturm R, Bauer O, Diedrich C and Diedrich K: Mini-swim up: a new technique of sperm preparation for intra-cytoplasmic sperm injection. J Assist Reprod Genet 12: 428-433, 1995.
22. Al-Hasani S, Ludwig M, Karabulut O, Al-Dimassi F, Bauer O, Sturm R, Kahle D and Diedrich K: Results of intracytoplasmic sperm injection (ICSI) using microprocessor controlled TransferMan Eppendorf Manipulator system. J Middle East Fertil Soc 4: 41-44, 1999.
23. Agarwal SK, Vogel K, Weitsman SR and Magoffin DA: Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulose and theca cells of the human ovary. J Clin Endocrinol Metab 84: 1072-1076, 1999.
24. Fernandez-Real JM, Gutierrez C, Vendrell J, Casamitjana R and Ricart W: Plasma soluble tumor necrosis factor-alpha receptors circulate in proportion to leptin levels during the menstrual cycle in lean but not in obese women. Eur J Endocrinol 143: 235-41, 2000.
25. Spicer LJ and Francisco CC: The adipose obese gene product, Leptin: evidence of a direct inhibitory role in ovarian function. Endocrinol 138: 3374-3379, 1997.
26. Spicer LJ and Francisco CC: Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis. Biol Reprod 58: 207-212, 1998.
27. Zachow RJ and Magoffin DA: Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17β production by the rat ovarian granulosa cells. Endocrinol 138: 847-850, 1997.
28. Karlsson C, Lindell K, Svensson E, Bergh C, Lind P, Billig H, Carlsson LMS and Carlsson B: Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab 82: 4144-4148, 1997.
29. Brannian JD, Zhao Y and McElroy M: Leptin inhibits gonadotrophin-stimulated granulosa cell progesterone production by antagonizing insulin action. Hum Reprod 14: 1445-1448, 1999.
30. Kitawaki J, Kusuki I, Koshiba H, Tsukamoto K and Honjo H: Leptin directly stimulates aromatise activity in human luteinized granulosa cells. Mol Hum Reprod 5: 708-713, 1999.