Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas

In Vivo

Volumn 18, Issue 5, 2004, Pages 593-602

  Bodey, Bela ^a,b,f   Bodey, Vivian ^a,b   Siegel, Stuart E ^a,b   Nasir, Aejaz ^c   Coppola, Domenico ^c   Hakam, Ardeshir ^c   Kaiser, Hans E ^d,e  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF VIENNA   (Austria)

^f NONE   (United States)

Author keywords

Antigen detection technique; Apoptosis; Astrocytoma; Caspases; Glioblastoma

Indexed keywords

ALKALINE PHOSPHATASE; CASPASE; CASPASE 3; CASPASE 6; CASPASE 8; CASPASE 9; CELL ANTIGEN;

ANALYTIC METHOD; ANAPLASTIC CARCINOMA; ANTIGEN DETECTION; APOPTOSIS; ARTICLE; ASTROCYTOMA; CANCER GRADING; CANCER IMMUNOTHERAPY; CELL NUCLEUS; CONJUGATION; CONTROLLED STUDY; CYTOPLASM; ENZYME LOCALIZATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; MALIGNANT NEOPLASTIC DISEASE; MICROENVIRONMENT; PROGNOSIS; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; TUMOR CELL; TUMOR IMMUNOLOGY;

EID: 6944226268     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (71)

1. Ashkenazi A and Dixit VM: Death receptors: signaling and modulation. Science 281: 1305-1308, 1998.
2. Xerri L, Devilard E, Ayello C, Brousset P, Reed JC, Emile JF, Hassoun J, Parmentier S and Birg F: Cysteine protease CPP32, but not Ich1-L, is expressed in germinal center B cells and their neoplastic counterparts. Hum Pathol 28: 912-921, 1997.
3. Srinivasan A, Roth KA, Sayers RO, Shindler KS, Wong AM, Fritz LC and Tomaselli KJ: In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system. Cell Death Differ 5: 1004-1016, 1998.
4. Kerr JF, Wyllie AH and Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
5. Derradji H and Baatout S: Apoptosis: a mechanism of cell suicide. In Vivo 17: 185-192, 2003.
6. Arends MJ and Wyllie AH: Apoptosis: Mechanisms and roles in pathology. Int Rev Exp Pathol 32: 223-254, 1991.
7. Patel T, Gores GJ and Kaufmann SH: The role of proteases during apoptosis. FASEB J 10: 587-597, 1996.
8. Mischak R: Assessment of caspase activity: synthetic substrates and inhibitors. Bioconcepts 9.2: 1-20, 2003.
9. Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT and Nicholson DW: A combinatorial approach defines specificities of members of the caspase family and granzyme B. J Biol Chem 272: 17907-17911, 1997.
10. Chang HY and Yang X: Proteases for cell suicide: Function and regulation of caspases. Mol Biol Rev 64: 821-846, 2000.
11. Earnshaw WC, Martins LM and Kaufmann SH: Mammalian caspases: structure, activation, substrates and functions during apoptosis. Ann Rev Biochem 68: 383-424, 1999.
12. Hengartner MO: The biochemistry of apoptosis. Nature 407 769-776, 2000.
13. Kohler C, Orrenius S and Zhivotvsky B: Evaluation of caspase activity in apoptotic cells. J Immunol Methods 265: 97-110, 2002.
14. Ravagnan L, Roumier T and Kroemer G: Mitochondria, the killer organelles and their weapons. J Cell Physiol 192: 131-137, 2002.
15. Liu X, Kim CN, Yang J, Jemmerson R and Wang X: Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86: 147-157, 1996.
16. Jia L, Patwari Y, Kelsey SM, Srinivasula SM, Agrawal SG, Alnemri ES and Newland AC: Role of Smac in human leukaemic cell apoptosis and proliferation. Oncogene 22: 1589-1599, 2003.
17. Krajewska M, Wang HG, Krajewski S, Zapata JM, Shabaik A, Gascoyne R, and Reed JC: Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. Cancer Res 57: 1605-1613, 1997.
18. Mallat Z, Ohan J, Leseche G and Tedgui A: Colocalization of CPP-32 with apoptotic cells in human atherosclerotic plaques. Circulation 96: 424-428, 1997.
19. Nakagawara A, Nakamura Y, Ikeda H, Hiwasa T, Kuida K, Su MS, Zhao H, Cnaan A and Sakiyama S: High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas. Cancer Res 57: 4578-4584, 1997.
20. Yuan J and Horvitz HR: The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Dev Biol 138: 33-41, 1990.
21. Yuan J, Shaham S, Ledoux S, Ellis HM and Horvitz HR: The C. elegans death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75: 641-652, 1993.
22. Stennicke HR and Salvesen GS: Biochemical characteristics of caspases-3, -6, -7 and -8. J Biol Chem 272: 25719-25723, 1997.
23. Faleiro L, Kobayashi R, Fearnhead H and Lazebnik Y: Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells. EMBO J 16: 2271-2281, 1997.
24. Srinivasula SM, Ahmad M, MacFarlane M, Luo Z, Huang Z, Fernandes-Alnemri T and Alnemri ES: Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits. J Biol Chem 273(17): 10107-10111, 1998.
25. Perera LP and Waldmann TA: Activation of human monocytes induces differential resistance to apoptosis with rapid down regulation of caspase-8/FLICE. Proc Natl Acad Sci USA 95: 14308-14313, 1998.
26. Wang CY, Mayo MW, Korneluk RG, Goeddel DV and Baldwin AS Jr: NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281: 1680-1683, 1998.
27. Bartz SR and Emerman M: Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8. J Virol 73: 1956-1963, 1999.
28. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES and Wang X: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489, 1997.
29. Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM and Mak TW: Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352, 1998.
30. Srinivasula SM, Ahmad M, Fernandes-Alnemri T and Alnemri ES: Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell 1: 949-957, 1998.
31. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P and Flavell RA: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337, 1998.
32. Virchow R: Cellular Pathology. New York, RM de Witt, 1860.
33. Williams BP, Abney ER and Raff MC: Macroglial cell development in embryonic rat brain: studies using monoclonal antibodies, flourescence-activated cell sorting and cell culture. Dev Biol 112: 126-134, 1985.
34. Bodey B, Bodey B Jr and Siegel SE: Immunophenotypical (IP) differential diagnosis and immunobiology of childhood primary brain tumors. A decade of experience. Int J Pediatric Hematol/Oncol 6: 65-84, 1998.
35. Jemal A, Myrray T, Samuels A, Ghafoor A, Ward E and Thun MJ: Cancer statistics, 2003. CA Cancer J Clin 53: 5-26, 2003.
36. Plate KH, Breier G, Weich HA and Risau W: Vascular endothelial growth factor and glioma angiogenesis factor in human gliomas in vivo. Nature 359: 845-848, 1992.
37. Falchetti ML, Pierconti F, Casalbore P, Maggiano N, Levi A, Larocca LM and Pallini R: Glioblastoma induces vascular endothelial cells to express telomerase in vitro. Cancer Res 63: 3750-3754, 2003.
38. Russel DS and Rubinstein LJ: Pathology of Tumors of the Nervous System. Baltimore, Williams & Wilkins, Ed. 3, pp. 83-350, 1989.
39. Flannery T, Gibson D, Mirakhur M, McQuaid S, Greenan C, Trimble A, Walker B, McCormick D and Johnston PG: The clinical significance of cathepsin S expression in human astrocytomas. Amer J Pathol 163: 175-182, 2003.
40. Zulch KJ and Wechsler W: Pathology and Classification of Gliomas. Progr Neurol Surg, vol. 2, Karger, Basel-New York, pp 1-84, 1968.
41. Zulch KJ: Histologic classification of tumours of the central nervous system. International Histological Classification of Tumours, No. 21, World Health Organization, Geneva, 1979.
42. Zulch KJ: Principles of the new World Health Organization (WHO) classification of brain tumors. Neuroradiology 19: 59-66, 1980.
43. Szymas J: Histologic classification of central nervous system tumors by the World Health Organization. Pol J Pathol 45: 81-91, 1994.
44. Szymas J: Diagnostic immunohistochemistry of tumors of the central nervous system. Folia Neuropathol 32: 209-214, 1994.
45. Duhamel RC and Whitehead JS: Prevention of nonspecific binding of avidin. Methods Enzymol 184: 201-207, 1990.
46. Diamandis EP and Christopoulos TK: The biotin-(strept)avidin system: principles and applications in biotechnology. Clin Chem 37: 625-636, 1991.
47. Hsu SM, Raine L and Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison of ABC and unlabeled antibody (PAP) procedure. J Histochem Cytochem 29: 577-581, 1981.
48. Bodey B, Bodey B Jr, Siegel SE and Kaiser HE: Fas (APO-1, CD95) receptor expression in childhood astrocytomas. Is it a marker of the major apoptotic pathway or a signaling receptor for immune escape of neoplastic cells? In Vivo 13: 357-373, 1999.
49. Bodey B, Bodey B Jr, Siegel SE and Kaiser HE: Matrix metalloproteinase expression in childhood astrocytomas. Anticancer Res 20: 3287-3292, 2000.
50. Bodey B, Bodey B Jr, Siegel SE and Kaiser HE: Significant differences in the matrix metalloproteinase expression profiles of spontaneous medulloblastomas/primitive neuroectodermal tumors as compared with their xenografted, established tumor cell line-derived counterparts. In Vivo 14: 675-682, 2000.
51. Bodey B: The significance of immunocytochemistry in the diagnosis and therapy of neoplasms. Exp Opin Biolog Ther 2: 371-393, 2002.
52. Bodey B, Siegel SE and Kaiser AE: MAGE-1, a cancer-testis antigen, expression in childhood astrocytomas as an indicator of tumor progression. In Vivo 16: 583-588, 2002.
53. Shi S-R, Key ME and Kalra KL: Antigen retrieval in formalin fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 39: 741-748, 1991.
54. Shi S-R, Cote C, Kalra KL, Taylor CR and Tandon AK: A technique for retrieving antigens in formalin-fixed, routinely acid-decalcified, celloidin-embedded human temporal bone sections for immunohistochemistry. J Histochem Cytochem 40: 787-792, 1992.
55. Key ME, Shi S-R and Kalra KL: Antigen retrieval in formalin fixed tissues using microwave energy. US Patent # 5,244,787; 14 September 1993.
56. Beckstead JH: Improved antigen retrieval in formalin-fixed, paraffin-embedded tissues. Appl Immunohistochem 2: 274-281, 1994.
57. Shi SR, Cote RJ and Taylor CR: Antigen retrieval techniques: current perspectives. J Histochem Cytochem 49: 931-937, 2001.
58. Shi SR, Cote RJ and Taylor CR: Antigen retrieval immunohistochemistry: past, present and future. J Histochem Cytochem 45: 327-343, 1997.
59. Battifora H: The multitumor (sausage) tissue block: novel method for immunohistochemical antibody testing. Lab Invest 55: 244-248, 1986.
60. Battifora H and Mehta P: The checkerboard tissue block. An improved multitissue control block. Lab Invest 63: 722-724, 1990.
61. Bodey B, Zeltzer PM, Saldivar V and Kemshead J: Immunophenotyping of childhood astrocytomas with a library of monoclonal antibodies. Int J Cancer 45: 1079-1087, 1990.
62. Vakkala M, Paakko P and Soini Y: Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion. Br J Cancer 81: 592-599, 1999.
63. Yoo NJ, Kim HS, Kim SY, Park WS, Kim SH, Lee JY and Lee SH: Stomach cancer highly expresses both initiator and effector caspases; an immunohistochemical study. APMIS 110: 825-832, 2002.
64. Bullard DE, Gillespie Y, Mahaley MS and Bigner DD: Immunobiology of human gliomas. Semin Oncol 13: 94-109, 1986.
65. Ray SK, Patel SJ, Welsh CT, Wilford GG, Hogan EL and Banik NL: Molecular evidence of apoptotic death in malignant brain tumors including glioblastoma multiforme: upregulation of calpain and caspase-3. J Neurosci Res 69: 197-206, 2002.
66. Didenko VV, Ngo HN, Minchew C and Baskin DS: Apoptosis of T lymphocytes invading glioblastomas multiforme: a possible tumor defense mechanism. J Neurosurg 96: 580-584, 2002.
67. Chen GG, Chu YS, Chak EC, Leung BC and Poon WS: Induction of apoptosis in glioma cells by molecules released from activated macrophages. J Neurooncol 57: 179-186, 2002.
68. Yuan SS, Chang HL, Chen HW, Yeh YT, Kao YH, Lin KH, Wu YC and Su JH: Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway. Life Sci 72: 2853-2861, 2003.
69. Fukazawa T, Walter B and Owen-Schaub LB: Adenoviral Bid overexpression induces caspase-dependent cleavage of truncated Bid and p53-independent apoptosis in human nonsmall cell lung cancers. J Biol Chem 278: 25428-25434, 2003.
70. Chen GG, Chak EC, Chun YS, Lam IK, Sin FL, Leung BC, Ng HK and Poon WS: Glioma apoptosis induced by macrophages involves both death receptor-dependent and independent pathways. J Lab Clin Med 141: 190-199, 2003.
71. Shinoura N and Hamada H: Gene therapy using an adenovirus vector for apoptosis-related genes is a highly effective therapeutic modality for killing glioma cells. Curr Gene Ther 3: 147-153, 2003.