A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing

Autonomic Neuroscience: Basic and Clinical

Volumn 150, Issue 1-2, 2009, Pages 127-130

  Sletten, David M ^a   Kimpinski, Kurt ^a   Weigand, Stephen D ^a   Low, Phillip A ^a  

^a MAYO CLINIC   (United States)

Author keywords

Acetylcholine; Gel; Iontophoresis; QSART; Solution; Vehicle

Indexed keywords

ACETYLCHOLINE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GEL; HUMAN; IONTOPHORESIS; MALE; MEASUREMENT; NERVE FIBER; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; QUANTITATIVE SUDOMOTOR AXON REFLEX TESTING; SWEAT;

ACETYLCHOLINE; ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; AUTONOMIC FIBERS, POSTGANGLIONIC; BIOPHYSICS; CHOLINERGIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; ELECTRIC STIMULATION; FEMALE; GELS; HUMANS; MALE; MIDDLE AGED; PAIN MEASUREMENT; REACTION TIME; REFLEX; SWEATING; YOUNG ADULT;

EID: 69349090392     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autneu.2009.05.250     Document Type: Article

References (16)

1. Abou-Elenin K., Xydakis A., Hamdy O., Economides P.A., Horton E.S., and Veves A. The effect of aspirin and various iontophoresis solution vehicles on skin microvascular reactivity. Microvasc. Res. 63 (2002) 91-95
2. Christen S., Delachaux A., Dischl B., Golay S., Liaudet L., Feihl F., and Waeber B. Dose-dependent vasodilatory effects of acetylcholine and local warming on skin microcirculation. J. Cardiovasc. Pharmacol. 44 (2004) 659-664
3. Cracowski J.L., Minson C.T., Salvat-Melis M., and Halliwill J.R. Methodological issues in the assessment of skin microvascular endothelial function in humans. Trends Pharmacol. Sci. 27 (2006) 503-508
4. Ferrell W.R., Ramsay J.E., Brooks N., Lockhart J.C., Dickson S., McNeece G.M., Greer I.A., and Sattar N. Elimination of electrically induced iontophoretic artefacts: implications for non-invasive assessment of peripheral microvascular function. J. Vasc. Res. 39 (2002) 447-455
5. Khan F., Newton D.J., Smyth E.C., and Belch J.J. Influence of vehicle resistance on transdermal iontophoretic delivery of acetylcholine and sodium nitroprusside in humans. J. Appl. Physiol. 97 (2004) 883-887
6. Kihara M., Mitsui M., Nishikawa S., Nishimoto K., and Takahashi M. Comparison of electrophysiologic and autonomic tests in sensory diabetic neuropathy. Clinic. Auton. Res. 8 (1998) 213-220
7. Losty H.C., Wheatley H., and Doull I. The evaluation of a novel conductometric device for the diagnosis of cystic fibrosis. Ann. Clin. Biochem. 43 (2006) 375-381
8. Low P.A. Testing the autonomic nervous system. Semin. Neurol. 23 (2003) 407-421
9. Low P.A., and Sletten D.M. Laboratory evaluation of autonomic function. In: Low P.A., and Benarroch E.E. (Eds). Clinical Autonomic Disorders (2008), Lippincott, Williams and Wilkins, Philadelphia 130-163
10. Low P.A., Caskey P.E., Tuck R.R., Fealey R.D., and Dyck P.J. Quantitative sudomotor axon reflex test in normal and neuropathic subjects. Ann. Neurol. 14 (1983) 573-580
11. Low P.A., Opfer-Gehrking T.L., and Kihara M. In vivo studies on receptor pharmacology of the human eccrine sweat gland. Clinic. Auton. Res. 2 (1992) 29-34
12. Low P.A., Denq J.C., Opfer-Gehrking T.L., Dyck P.J., O'Brien P.C., and Slezak J.M. Effect of age and gender on sudomotor and cardiovagal function and blood pressure response to tilt in normal subjects. Muscle Nerve 20 (1997) 1561-1568
13. Low V.A., Sandroni P., Fealey R.D., and Low P.A. Detection of small-fiber neuropathy by sudomotor testing. Muscle Nerve 34 (2006) 57-61
14. Singer W., Spies J.M., McArthur J., Low J., Griffin J.W., Nickander K.K., Gordon V., and Low P.A. Prospective evaluation of somatic and autonomic small fibers in selected autonomic neuropathies. Neurology 62 (2004) 612-618
15. Sletten D.M., Nickander K.K., and Low P.A. Stability of acetylcholine chloride solution in autonomic testing. J. Neurol. Sci. 234 (2005) 1-3
16. Wang Y., Thakur R., Fan Q., and Michniak B. Transdermal iontophoresis: combination strategies to improve transdermal iontophoretic drug delivery. Eur. J. Pharm. Biopharm. 60 (2005) 179-191