FGF2 stimulates the proliferation of human mesenchymal stem cells through the transient activation of JNK signaling

FEBS Letters

Volumn 583, Issue 17, 2009, Pages 2922-2926

  Ahn, Hee Jin ^a   Lee, Woo Jung ^a   Kwack, KyuBum ^a   Kwon, Young Do ^a  

^a CHA University   (South Korea)

Author keywords

c Jun N terminal kinase; Differentiation potential; FGF2; Mesenchymal stem cell; Proliferation

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; FIBROBLAST GROWTH FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

ADIPOCYTE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTHRACENES; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTOR 2; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MESENCHYMAL STEM CELLS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 69249234737     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.07.056     Document Type: Article

References (24)

1. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman M.A., Simonetti D.W., Craig S., and Marshak D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
2. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276 (1997) 71-74
3. Di Nicola M., Carlo-Stella C., Magni M., Milanesi M., LOngoni P.D., Matteucci P., Grisanti S., and Gianni A.M. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99 (2002) 3838-3843
4. Le Blanc K., and Pittenger M.F. Mesenchymal stem cells: progress toward promise. Cytotherapy 7 (2005) 36-45
5. Kang Y.J., Jeon E.S., Song H.Y., Woo J.S., Jung J.S., Kim Y.K., and Kim J.H. Role of c-Jun N-terminal kinase in the PDGF-induced proliferation and migration of human adipose tissue-derived mesenchymal stem cells. J. Cell. Biochem. 95 (2005) 1135-1145
6. Jian H., Shen X., Liu I., Semenov M., He X., and Wang X.-F. Smad3-dependent nuclear translocation of β-catenin is required for TGF-β1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Genes Dev. 20 (2006) 666-674
7. Solchaga L.A., Penick K., Porter J.D., Goldberg V.M., Caplan A.I., and Welter J.F. FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J. Cell. Physiol. 203 (2005) 398-409
8. Tsutsumi S., Shimazu A., Miyazaki K., Pan H., Koike C., Yoshida E., Takagishi K., and Kato Y. Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem. Biophys. Res. Commun. 288 (2001) 413-419
9. Bianchi G., Banfi A., Mastrogiacomo M., Notaro R., Luzzatto L., Cancedda R., and Quarto R. Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2. Exp. Cell Res. 287 (2003) 98-105
10. Zaragosi L.-E., Ailhaud G., and Dani C. Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. Stem cells 24 (2006) 2412-2419
11. Dailey L., Ambrosetti D., Mansukhani A., and Basilico C. Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Fac. Rev. 16 (2005) 233-247
12. Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., and Goldfarb M. Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 (1996) 15292-15297
13. Dvorak P., Dvorakova D., and Hampl A. Fibroblast growth factor signaling in embryonic and cancer stem cells. FEBS Lett. 580 (2006) 2869-2874
14. Qi M., and Elion E.A. MAP kinase pathways. J. Cell. Sci. 118 (2005) 3569-3572
15. Ito T., Swada R., Fujiwara Y., Seyama Y., and Tsuchiya T. FGF-2 suppress cellular senescence of human mesenchymal stem cells by down-regulation of TGF-β2. Biochem. Biophys. Res. Commun. 359 (2007) 108-114
16. Bertelsen M., and Sanfridson A. Inflammatory pathway analysis using a high content screening platform. Assay Drug Dev. Tech. 3 (2005) 261-271
17. Chen Y.-R., Wang X., Templeton D., Davis R.J., and Tan T.-H. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. J. Biol. Chem. 271 (1996) 31929-31936
18. Ventura J.-J., Hubner A., Zhang C., Flavell R.A., Shokat K.M., and Davis R.J. Chemical genetic analysis of the time course of signal transduction by JNK. Mol. Cell 21 (2006) 701-710
19. Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270 (1995) 1326-1331
20. Su B., Jacinto E., Hibi M., Kallunki T., Karin M., and Ben-Neriah Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77 (1994) 727-736
21. Suga H., Eto H., Shigeura T., Inoue K., Aoi N., Kato H., Nishimura S., Manabe I., Gonda K., and Yoshimura K. FGF-2-induced HGF secretion by adipose-derived stromal cells inhibits post-injury fibrogenesis through a JNK-dependent mechanism. Stem Cells 27 (2009) 238-249
22. Kinnaird T., Stabile E., Burnett M.S., Lee C.W., Barr S., Fuchs S., and Epstein S.E. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ. Res. 94 (2004) 678-685
23. Boyer L.A., Lee T.I., Cole M.F., Johnstone S.E., Levine S.S., Zucker J.P., Guenther M.G., Kumar R.M., Murray H.L., Jenner R.G., Gifford D.K., Melton D.A., Jaenisch R., and Young R.A. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122 (2005) 947-956
24. Tominaga S., Yamaguchi T., Takahashi S.I., Hirose F., and Osumi T. Negative regulation of adipogenesis from human mesenchymal stem cells by Jun N-terminal kinase. Biochem. Biophys. Res. Commun. 326 (2005) 499-504