Structural basis for the Helicobacter pylori-carcinogenic TNF-α-inducing protein

Biochemical and Biophysical Research Communications

Volumn 388, Issue 2, 2009, Pages 193-198

  Tsuge, Hideaki ^a   Tsurumura, Toshiharu ^a   Utsunomiya, Hiroko ^a   Kise, Daisuke ^a   Kuzuhara, Takashi ^a   Watanabe, Tatsuro ^b   Fujiki, Hirota ^a   Suganuma, Masami ^b  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b SAITAMA CANCER CENTER   (Japan)

Author keywords

Carcinogenic protein; Crystal structure; Helicobacter pylori; Tip deletion mutant; TNF inducing protein (Tip )

Indexed keywords

BACTERIAL PROTEIN; HOMODIMER; TUMOR NECROSIS FACTOR ALPHA INDUCING PROTEIN; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BIOLOGICAL ACTIVITY; CARCINOGENIC ACTIVITY; CARCINOGENICITY; CIRCULAR DICHROISM; COVALENT BOND; CRYSTAL STRUCTURE; DELETION MUTANT; DIMERIZATION; DISULFIDE BOND; HELICOBACTER PYLORI; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; HELICOBACTER PYLORI; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SEQUENCE DELETION; STOMACH NEOPLASMS; TUMOR NECROSIS FACTOR-ALPHA;

HELICOBACTER PYLORI;

EID: 69249230755     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.07.121     Document Type: Article

References (28)

1. Correa P. Helicobacter pylori infection and gastric cancer. Cancer Epidemiol. Biomarkers Prev. 2 (2003) 238s-241s
2. Peek Jr. R.M., and Blaser M.J. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat. Rev. Cancer 2 (2002) 28-37
3. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Schistosomes, liver flukes and Helicobacter pylori, IARC Monogr. Eval. Carcinog. Risks Hum. 61 (1994) 1-241.
4. Covacci A., Censini S., Bugnoli M., et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc. Natl. Acad. Sci. USA 90 (1993) 5791-5795
5. Phadnis S.H., Ilver D., Janzon L., Normark S., and Westblom T.U. Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Infect. Immun. 62 (1994) 1557-1565
6. Nilsson C., Sillen A., Eriksson L., et al. Correlation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease. Infect. Immun. 71 (2003) 6573-6581
7. Normark S., Nilsson C., Normark B.H., and Hornef M.W. Persistent infection with Helicobacter pylori and the development of gastric cancer. Adv. Cancer Res. 90 (2003) 63-89
8. Shimoyama T., Fukuda S., Tanaka M., Mikami T., Saito Y., and Munakata A. High prevalence of the CagA-positive Helicobacter pylori strains in Japanese asymptomatic patients and gastric cancer patients. Scand. J. Gastroenterol. 32 (1997) 465-468
9. Park S.M., Park J., Kim J.G., et al. Infection with Helicobacter pylori expressing the cagA gene is not associated with an increased risk of developing peptic ulcer diseases in Korean patients. Scand. J. Gastroenterol. 33 (1998) 923-927
10. Suganuma M., Okabe S., Marino M.W., Sakai A., Sueoka E., and Fujiki H. Essential role of tumor necrosis factor α (TNF-α) in tumor promotion as revealed by TNF-α-deficient mice. Cancer Res. 59 (1999) 4516-4518
11. Moore R.J., Owens D.M., Stamp G., et al. Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat. Med. 5 (1999) 828-831
12. Suganuma M., Kurusu M., Suzuki K., et al. New tumor necrosis factor-α-inducing protein released from Helicobacter pylori for gastric cancer progression. J. Cancer Res. Clin. Oncol. 131 (2005) 305-313
13. Kuzuhara T., Suganuma M., Kurusu M., and Fujiki H. Helicobacter pylori-secreting protein Tipα is a potent inducer of chemokine gene expressions in stomach cancer cells. J. Cancer Res. Clin. Oncol. 133 (2007) 287-296
14. Suganuma M., Kuzuhara T., Yamaguchi K., and Fujiki H. Carcinogenic role of tumor necrosis factor-α inducing protein of Helicobacter pylori in human stomach. J. Biochem. Mol. Biol. 39 (2006) 1-8
15. Suganuma M., Yamaguchi K., Ono Y., et al. TNF-α-inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells. Int. J. Cancer 123 (2008) 117-122
16. Kuzuhara T., Suganuma M., Oka K., and Fujiki H. DNA-binding activity of TNF-α inducing protein from Helicobacter pylori. Biochem. Biophys. Res. Commun. 362 (2007) 805-810
17. Otwinowski Z., and Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276 (1997) 307-326
18. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50 (1994) 760-763.
19. Terwilliger T.C. SOLVE and RESOLVE: automated structure solution and density modification. Methods Enzymol. 374 (2003) 22-37
20. McRee D.E. XtalView/Xfit - a versatile program for manipulating atomic coordinates and electron density. J. Struct. Biol. 125 (1999) 156-165
21. Laskowski A., Moss S., and Thornton M. PROCHECK: a program to check the stereochemical quality of protein structures. J. Appl. Cryst. 26 (1993) 283-291
22. Combet C., Jambon M., Deleage G., and Geourjon C. Geno3D: automatic comparative molecular modelling of protein. Bioinformatics 18 (2002) 213-214
23. Holm L., and Sander C. Dali: a network tool for protein structure comparison. Trends Biochem. Sci. 20 (2000) 478-480
24. Bieger B., Essen L.O., and Oesterhelt D. Crystal structure of halophilic dodecin: a novel, dodecameric flavin binding protein from Halobacterium salinarum. Structure 11 (2003) 375-385
25. Kuzuhara T., Suganuma M., Tsuge H., and Fujiki H. Presence of a motif conserved between Helicobacter pylori TNF-α-inducing protein (Tipα) and penicillin-binding proteins. Biol. Pharm. Bull. 28 (2005) 2133-2137
26. Tosi T., Cioci G., Jouravleva K., Dian C., and Terradot L. Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Hellicobacter pylori. FEBS Lett. 583 (2009) 1581-1585
27. Yoshida M., Wakatsuki Y., Kobayashi Y., et al. Cloning and characterization of a novel membrane-associated antigenic protein of Helicobacter pylori. Infect. Immun. 67 (1999) 286-293
28. T. Watanabe, H. Tsuge, M. Beppu, K. Hirano, H. Fujiki, M. Suganuma, Identification of nucleolin as a specific binding protein of Tipα, carcinogenic factor of Helicobacter pylori, in: Proceedings of 9th Korea-Japan Symposium on Cancer and Aging, 2009, p. 44.