A Toxoplasma type 2C serine-threonine phosphatase is involved in parasite growth in the mammalian host cell

Microbes and Infection

Volumn 11, Issue 12, 2009, Pages 935-945

  Jan, Gaelle ^a,b   Delorme, Violaine ^a,b,c   Saksouk, Nehmé ^d   Abrivard, Marie ^a,b   Gonzalez, Virginie ^a,b   Cayla, Xavier ^e   Hakimi, Mohamed Ali ^d   Tardieux, Isabelle ^a,b  

^a INSTITUT COCHIN   (France)

^b INSERM   (France)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIV GRENOBLE ALPES   (France)

^e UNIVERSITÉ DE TOURS   (France)

Author keywords

Cell cycle; Cytokinesis; Phosphatases; TgPP2C; Toxoplasma gondii

Indexed keywords

PHOSPHATASE; SERINE THREONINE PHOSPHATASE 2C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE REGULATION; CONTROLLED STUDY; CYTOKINESIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; HOST CELL; HUMAN; HUMAN CELL; MAMMAL CELL; MITOSIS; NONHUMAN; NUCLEAR DIVISION; PARASITE DEVELOPMENT; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TACHYZOITE; TOXOPLASMA GONDII; TRANSGENIC ORGANISM; WILD TYPE;

ANIMALS; CELL DIVISION; CELL LINE; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; CYTOPLASM; HUMANS; PHOSPHOPROTEIN PHOSPHATASES; RATS; TOXOPLASMA;

ANIMALIA; APICOMPLEXA; MAMMALIA; PROTOZOA; TOXOPLASMA; TOXOPLASMA GONDII;

EID: 69249223011     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2009.06.002     Document Type: Article

References (30)

1. Radke J.R., Striepen B., Guerini M.N., Jerome M.E., Roos D.S., and White M.W. Defining the cell cycle for the tachyzoite stage of Toxoplasma gondii. Mol. Biochem. Parasitol. 115 (2001) 165-175
2. Saeij J.P., Boyle J.P., and Boothroyd J.C. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends Parasitol. 21 (2005) 476-481
3. Gubbels M.J., White M., and Szatanek T. The cell cycle and Toxoplasma gondii cell division: tightly knit or loosely stitched?. Int. J. Parasitol. 38 (2008) 1343-1358
4. Hu K., Mann T., Striepen B., Beckers C.J., Roos D.S., and Murray J.M. Daughter cell assembly in the protozoan parasite Toxoplasma gondii. Mol. Biol. Cell 13 (2002) 593-606
5. Hu K., Roos D.S., Angel S.O., and Murray J.M. Variability and heritability of cell division pathways in Toxoplasma gondii. J. Cell Sci. 117 (2004) 5697-5705
6. Gubbels M.J., Vaishnava S., Boot N., Dubremetz J.F., and Striepen B. Organizational changes of the daughter basal complex during the parasite replication of Toxoplasma gondii. J. Cell Sci. 1 119 (2006) 2236-2245
7. Hu K. Organizational changes of the daughter basal complex during the parasite replication of Toxoplasma gondii. PLoS Pathog. 4 (2008) e10
8. Striepen B., Jordan C.N., Reiff S., and van Dooren G.G. Building the perfect parasite: cell division in apicomplexa. PLoS Pathog. 3 (2007) e78
9. Morrissette N.S., and Sibley L.D. Disruption of microtubules uncouples budding and nuclear division in Toxoplasma gondii. J. Cell Sci. 115 (2002) 1017-1025
10. MacKeigan J.P., Murphy L.O., and Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat. Cell Biol. 7 (2005) 591-600
11. Taylor S., Barragan A., Su C., Fux B., Fentress S.J., Tang K., Beatty W.L., Hajj H.E., Jerome M., Behnke M.S., White M., Wootton J.C., and Sibley L.D. A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science 314 (2006) 1776-1780
12. Cohen P. Classification of protein-serine/threonine phosphatases: identification and quantitation in cell extracts. Methods Enzymol. 201 (1991) 389-398
13. MacKintosh C., Coggins J., and Cohen P. Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase. Biochem J. 273 (1991) 733-738
14. Rogers J.P., Beuscher IV A.E., Flajolet M., McAvoy T., Nairn A.C., Olson A.J., and Greengard P. Discovery of protein phosphatase 2C inhibitors by virtual screening. J. Med. Chem. 49 (2006) 1658-1667
15. Yamaguchi H., Durell S.R., Feng H., Bai Y., Anderson C.W., and Appella E. Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1. Biochemistry 45 (2006) 13193-13202
16. Stern A., Privman E., Rasis M., Lavi S., and Pupko T. Evolution of the metazoan protein phosphatase 2C superfamily. J. Mol. Evol. 64 (2007) 61-70
17. Lammers T., and Lavi S. Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit. Rev. Biochem. Mol. Biol. 42 (2007) 437-461
18. De Smedt V., Poulhe R., Cayla X., Dessauge F., Karaiskou A., Jessus C., and Ozon R. Thr-161phosphorylation of monomeric Cdc2. Regulation by protein phosphatase 2C in Xenopus oocytes. J. Biol. Chem. 277 (2002) 28592-28600
19. Leroy C., Lee S.E., Vaze M.B., Ochsenbien F., Guerois R., Haber J.E., and Marsolier-Kergoat M.C. PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol. Cell 11 (2003) 827-835
20. Ofek P., Ben-Meir D., Kariv-Inbal Z., Oren M., and Lavi S. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. J. Biol. Chem. 278 (2003) 14299-14305
21. Delorme V., Cayla X., Faure G., Garcia A., and Tardieux I. Actin dynamics is controlled by a casein kinase II and phosphatase 2C interplay on Toxoplasma gondii Toxofilin. Mol. Biol. Cell 14 (2003) 1900-1912
22. Gilbert L.A., Ravindran S., Turetzky J.M., Boothroyd J.C., and Bradley P.J. Toxoplasma gondii targets a protein phosphatase 2C to the nuclei of infected host cells. Eukaryot Cell 6 (2007) 73-83
23. Roos D.S., Donald R.G., Morrissette N.S., and Moulton A.L. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii. Methods Cell Biol. 45 (1994) 27-63
24. Saksouk N., Bhatti M.M., Kieffer S., Smith A.T., Musset K., Garin J., Sullivan Jr. W.J., Cesbron-Delauw M.F., and Hakimi M.A. Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii. Mol. Cell Biol. 25 (2005) 10301-10314
25. Poupel O., Boleti H., Axisa S., Couture-Tosi E., and Tardieux I. Toxofilin, a novel actin-binding protein from Toxoplasma gondii, sequesters actin monomers and caps actin filaments. Mol. Biol. Cell 11 (2000) 355-368
26. Agostinis P., Goris J., Waelkens E., Pinna L.A., Marchiori F., and Merlevede W. Dephosphorylation of phosphoproteins and synthetic phosphopeptides. Study of the specificity of the polycation-stimulated and MgATP-dependent phosphorylase phosphatases. J. Biol. Chem. 262 (1987) 1060-1064
27. Lifschitz-Mercer B., Sheinin Y., Ben-Meir D., Bramante-Schreiber L., Leider-Trejo L., Karby S., Smorodinsky N.I., and Lavi S. Protein phosphatase 2Calpha expression in normal human tissues: an immunohistochemical study. Histochem. Cell Biol. 116 (2001) 31-39
28. Kusuda K., Kobayashi T., Ikeda S., Ohnishi M., Chida N., Yanagawa Y., Shineha R., Nishihira T., Satomi S., Hiraga A., et al. Mutational analysis of the domain structure of mouse protein phosphatase 2Cbeta. Biochem. J. 332 (1998) 243-250
29. Xia D., Sanderson S.J., Jones A.R., Prieto J.H., Yates J.-R., Bromley E., Tomley F.M., Lal K., Sinden R.E., Brunk B.P., Roos D.S., and Wastling J.M. The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation. Genome Biol. 9 (2008) R116
30. Schweighofer A., Hirt H., and Meskiene I. Plant PP2C phosphatases: emerging functions in stress signaling. Trends Plant Sci. 9 (2004) 236-243