Biochemical and toxicological studies of aqueous extract of Syzigium aromaticum (L.) Merr. & Perry (Myrtaceae) in rodents

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 6, Issue 3, 2009, Pages 241-254

  Agbaje, E O ^a   Adeneye, A A ^b   Daramola, A O ^a  

^a UNIVERSITY OF LAGOS   (Nigeria)

^b LAGOS STATE UNIVERSITY   (Nigeria)

Author keywords

Aqueous extract; Biochemical parameters; Haematological parameters; Syzigium aromaticum; Toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN GLUCURONIDE; CHOLESTEROL; CREATININE; ELECTROLYTE; HEMOGLOBIN; LIVER ENZYME; PLANT EXTRACT; POTASSIUM; SODIUM; SYZIGIUM AROMATICUM EXTRACT; UNCLASSIFIED DRUG; UREA; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BIOASSAY; BIOCHEMISTRY; BLOOD ANALYSIS; BLOOD SAMPLING; BODY WEIGHT; BRAIN EDEMA; CLOVE; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVITY; ERYTHROCYTE COUNT; FEMALE; GASTRITIS; GASTROINTESTINAL DISEASE; HEMATOCRIT; HEMATOLOGY; HISTOPATHOLOGY; KIDNEY TUBULE NECROSIS; LD 50; LEUKOCYTE COUNT; LIVER DISEASE; LIVER FIBROSIS; LIVER FUNCTION; LUNG DISEASE; LYMPHOCYTE COUNT; MALE; MORTALITY; MYRTACEAE; NEUTROPHIL COUNT; NONHUMAN; ORGAN WEIGHT; PATCHY ATELECTASIS; PERIPORTAL INFLAMMATION; RAT; RESPIRATORY TRACT DISEASE; RODENT; SINUSOIDAL INFLAMMATORY INFILTRATION; SPICE; SYZIGIUM AROMATICUM; THROMBOCYTE COUNT; TOXICITY TESTING; WEIGHT GAIN;

ACUTE TOXICITY TESTS; ADMINISTRATION, ORAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; KIDNEY; LIVER; MICE; MYRTACEAE; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 69249220370     PISSN: 01896016     EISSN: 01896016     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Adebayo J.O., Adesokan A.A., Olatunji L.A., Buoro D.O., and Soladoye A.O. (2005). Effect of ethanolic extract of Bougainvillea spectabilis leaves on haematological and serum lipid variables in rats. Biokemistri 17 (1): 45-50
2. Adedapo A.A., Abatan M.O. and Olorunsogo O.O. (2004). Toxic effects of some plants in the genus Euphorbia on haematological and biochemical parameters of rats. Veterinarski Arhiv. 74(1): 53-62.
3. Agbaje E.O. (2008). Gastrointestinal effects of Syzigium aromaticum (L). Merr. & Perry (Myrtaceae) in Animal model. Nig. Qt. J. Hosp. Med. 18 (3): 137-141.
4. Balch P. and Balch J. (2000). Prescription for Nutritional Healing, 3rd ed. Garden City Park, N.Y. Avery. ISBN 158330771.
5. Bensky D.S., Clavey S. and Stoger E.(2004). Chinese Herbal Medicine: Materia Medica. Seattle, W.A: Eastland Press. ISBN 0939616424.
6. Biod T. and Sirota B. (1948). In: Watson, A., et al. (Eds.), Practical Clinical Biochemistry, 4th ed. Prentice-Hall of India Private Ltd., New Delhi, India, pp. 142-145.
7. Bisset N. (1994). Herbal Drugs and Phytopharmaceuticals. Stuttgart, Germany, CRC Press, 130-131.
8. Brow S.A., Biggerstaff J. and Savidge G.F. (1992).Disseminated intravascular coagulation and hepatocellular necrosis due to clove oil. Blood Coagul. Fibrinolysis 3:665-668.
9. Burt S.A. and Reinders R.D. (2003). Natural products and nutritional supplements. Appl. Microb. 36(3): 162-7.
10. Calixto J.B. (2000). Efficacy, Safety, Quality control, marketing and regulatory guidelines for herbal medicines (Phytotherapeutic agents). Braz. J. Med. & Biol Res. 33 (2): 179-189.
11. Coles E.H. (1986). "Veterinary Clinical Pathology." W.B. Saunders, Philadelphia, U.S.A. pp. 10-42.
12. Dalziel J.M. (1937). The Useful Plants of West Tropical Africa. Crown Agents for the Colonies, London.
13. Dip E.C., Pereira N.A. and Fernandes P.D. (2004). Ability of Eugenol to reduce tongue edema induced by Dieffenbachia picta schott in mice. Toxicon. 43: 729-735.
14. Dorai T. and Aggarwal B.B. (2004). Role of chemopreventive agents in cancer therapy. Cancer Lett. 215: 129-140.
15. Fichi G., Flamini G., Giovanelli F., Otranto D. and Perrucci S. (2007). Efficacy of an essential oil of Eugenia caryophyllata against Psoroptes cuniculi. Exp. Parasitol. 115 (2): 168-172.
16. Ganong W.F. (2001). Review of Medical Physiology. 20th Edition. Lange Medical Books. McGraw Hill Companies Inc., New York. Pp 500-515.
17. Guyton A.C., and Hall J.E., (2000). A Textbook on Medical Physiology. 10th Edition. W.B. Saunders Company, Philadelphia. Pp. 382-401.
18. Imoru, J.O., Eno A.E., Unoh F.B., Nkanu, E.E., Ofem. O.E. and Ibu J.O. (2006).Haematopoietic Agent(s) in the crude extract from the leaves of Viscum album (Mustletoe). Nig. J. Hlth. Biom. Sc. 4 (2): 139-145.
19. Kobzik L. and Schoen F.J. (1994). The Lung. In: Cotran R.S., Kumar V., Robbins S.L. (Eds.): Robbins Pathologic Basis of Disease. 5th ed. W.B. Saunders Co., Philadelphia, U.S.A., pp. 673-734.
20. Lane B.W., Ellenhorn M.J., Hulbert T.V., McCarron M, (1991). Clove oil ingestion in an infant, Hum. Exp. Toxicol. 10 (4): 291-294.
21. Lawless J. (1995). The Illustrated Encyclopedia of Essential oils. Rockport, MA: Element. ISBN 1852306610
22. Lee K.G. and Shibamoto T. (2001). Antioxidant property of aroma extract isolated from clove bud (Syzigium aromaticum (L). Merr. Et Perry). Food Chem. 74: 443-448.
23. Liebermann L.L. (1958). A method for the estimation of serum cholesterol. Clin. Chem. 2: 26-30.
24. Lowry O.H., Rosebrough N.J., Farr L. and Randall R.J. (1957). Protein measurement with Folin phenol reagent. J. Biol. Chem. 193: 265.
25. Marsh W.H. (1965). Automated and manual direct methods for the determination of blood urea. Clinical Chemistry 2: 624-625.
26. 50 and its error by means of logarithmic probit graph paper. Proc. Sci. Expt. Biol. Med. 24: 839-840.
27. Murray R.K., Granner P.A., Mayer P.A., and Rodwell V.W. (2000). Harper's Biochemistry. 20th edition. McGraw-Hill, pp. 594-602.
28. Oduola T., Adeniyi F.A.A., Ogunyemi E.O., Bello I.S., Idowu T.O., and Subair H.G. (2007). Toxicity studies on an unripe Carica papaya aqueous extract: biochemical and haematological effects in wistar albino rats. J. Med. Plant Res. 1 (1): 001-004
29. Okonkwo J.E., Iyadi K.C., and Effiong C.O. 2004). Effect of chronic administration of haematological parameters of rats. Nig. J. Physiol. Sc. 19 (1-2):10-13.
30. Oyewole I.O., Mogaji Z.J., Awoyinka O.A. (2007). Biochemical and Toxicological studies of aqueous extract of Tithonia diversifolia (Hemsl.) leaves in Wistar albino rats. J. Med. Plants Res. 1(2): 030-033.
31. Prashar A., Locke I.C. and Evans C.S. (2006). Cytotoxicity of clove ( Syzigium aromaticum) oil and its major components to human skin cells. Cell Prolif. 39: 241-248.
32. Physical and Theoretical Chemistry Laboratory at Oxford (PTLC). 2005. Safety data for clove oil. Physical and Theoretical Chemistry Laboratory at Oxford. Retrieved April 6, 2008.
33. Sanchez-Elsner T., Ramirez J.R., Rodriguez-Sanz F., Varela E., Bernabew C. and Botella L.M. (2004). A cross talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SPI and smads. J. Mol. Biol. 36 (1): 9-24.
34. Spencer K. and Price C.P. (1977). Chemical analysis of bilirubin in biological fluids. Annals Clinical Biochemistry 14: 105-115.
35. Sigma Diagnostic, (1985). Transaminase (ALT/GPT) and (AST/GOT) Procedure No. 505.
36. Sigma Diagnostic, (1987). ALP Optimized Alkaline Phosphatase. Procedure No. DG 1245.
37. Treitz N.W. (1970). Fundamentals of Clinical Chemistry with Clinical Correlation. W.B. Sanders, Philadelphia, pp. 280-284.
38. Trongtokit Y.Y., Rongsriyan N., Komalamisra N. and Apiwathnasom L. (2005). Comparative repellency of 38 essential oils against mosquito bites. Phytother Res. 19(4): 303-9.
39. Walum E. (1998). Acute oral toxicity. Environ. Health Perspect. 106: 497-503.
40. Yakubu M.T., Akanji M.A. and Oladiji A.T. (2007). Hematological evaluation in male albino rats following chronic administration of aqueous extract of Fadogia agretis stem. PHCOG MAG ISSN 0973-1296, pp. 34-38.
41. 50 test for toxicological evaluation of chemical substances. Arch. Toxicol. 49 (1): 99-103.