Cooperative N-methyl-d-aspartate (NMDA) receptor antagonism and μ-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain

Pharmacological Research

Volumn 60, Issue 4, 2009, Pages 284-290

  Sotgiu, Maria Luisa ^a   Valente, Maurizio ^a   Storchi, Riccardo ^a,b   Caramenti, Giancarlo ^c   Biella, Gabriele E M ^a  

^a INSTITUTE OF MOLECULAR BIOIMAGING AND PHYSIOLOGY   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c CNR   (Italy)

Author keywords

Methadone; Neuropathic pain; NMDA receptors; Opioid receptors; Rat spinal WDR neurons

Indexed keywords

METHADONE; MU OPIATE RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NALOXONE; OPIATE RECEPTOR;

ADULT ANIMAL; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; EVOKED RESPONSE; HYPERACTIVITY; IONTOPHORESIS; MALE; NERVE COMPRESSION; NEUROPATHIC PAIN; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SPINAL CORD NERVE CELL;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; MALE; METHADONE; NEURALGIA; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, OPIOID, MU; SPINE;

EID: 69249218025     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.04.002     Document Type: Article

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