Prognostic significance and treatment implications of positive peritoneal cytology in endometrial adenocarcinoma: Unraveling a mystery

Gynecologic Oncology

Volumn 115, Issue 1, 2009, Pages 18-25

  Wethington, Stephanie L ^a,b   Barrena Medel, Nicanor I ^a,b   Wright, Jason D ^a,b   Herzog, Thomas J ^a,b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b Department of Medicine   (United States)

Author keywords

Endometrial carcinoma; Peritoneal cytology; Prognosis

Indexed keywords

ARTICLE; ASCITES FLUID CYTOLOGY; CANCER INVASION; CANCER RECURRENCE; CANCER STAGING; DIAGNOSTIC VALUE; ENDOMETRIUM CARCINOMA; HUMAN; PERITONEUM LAVAGE; PERITONEUM METASTASIS; PRIORITY JOURNAL; PROGNOSIS; RECURRENCE RISK; TREATMENT PLANNING;

CARCINOMA, ENDOMETRIOID; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; NEOPLASM STAGING; PERITONEAL CAVITY; PROGNOSIS; RISK FACTORS;

EID: 69249203528     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2009.06.019     Document Type: Article

References (55)

1. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., et al. Cancer statistics. CA Cancer J. Clin. 58 (2008) 71-96 2008
2. Katz V.L. Comprehensive gynecology. 5th ed (2007), Mosby Elsevier, Philadelphia
3. Uterine Neoplasms. Practice guidelines in oncology (2008), National Comprehensive Cancer, Network (NCCN)
4. Creasman W.T., Odicino F., Maisonneuve P., Beller U., Benedet J.L., Heintz A.P., et al. Carcinoma of the corpus uteri. Int. J. Gynaecol. Obstet. 83 Suppl 1 (2003) 79-118
5. Denschlag D., Tan L., Patel S., Kerim-Dikeni A., Souhami L., and Gilbert L. Stage III endometrial cancer: preoperative predictability, prognostic factors, and treatment outcome. Am. J. Obstet. Gynecol. 196 546 (2007) e1-7
6. van Wijk F.H., Huikeshoven F.J., Abdulkadir L., Ewing P.C., and Burger C.W. Stage III and IV endometrial cancer: a 20-year review of patients. Int. J. Gynecol. Cancer 16 (2006) 1648-1655
7. Creasman W.T., Disaia P.J., Blessing J., Wilkinson Jr. R.H., Johnston W., and Weed Jr. J.C. Prognostic significance of peritoneal cytology in patients with endometrial cancer and preliminary data concerning therapy with intraperitoneal radiopharmaceuticals. Am. J. Obstet. Gynecol. 141 (1981) 921-929
8. Imachi M., Tsukamoto N., Matsuyama T., and Nakano H. Peritoneal cytology in patients with endometrial carcinoma. Gynecol. Oncol. 30 (1988) 76-86
9. Kashimura M., Sugihara K., Toki N., Matsuura Y., Kawagoe T., Kamura T., et al. The significance of peritoneal cytology in uterine cervix and endometrial cancer. Gynecol. Oncol. 67 (1997) 285-290
10. Kennedy A.W., Peterson G.L., Becker S.N., Nunez C., and Webster K.D. Experience with pelvic washings in stage I and II endometrial carcinoma. Gynecol. Oncol. 28 (1987) 50-60
11. Kennedy A.W., Webster K.D., Nunez C., and Bauer L.J. Pelvic washings for cytologic analysis in endometrial adenocarcinoma. J. Reprod. Med. 38 (1993) 637-642
12. Konski A., Poulter C., Keys H., Rubin P., Beecham J., and Doane K. Absence of prognostic significance, peritoneal dissemination and treatment advantage in endometrial cancer patients with positive peritoneal cytology. Int. J. Radiat. Oncol. Biol. Phys. 14 (1988) 49-55
13. Lurain J.R., Rumsey N.K., Schink J.C., Wallemark C.B., and Chmiel J.S. Prognostic significance of positive peritoneal cytology in clinical stage I adenocarcinoma of the endometrium. Obstet. Gynecol. 74 (1989) 175-179
14. Mazurka J.L., Krepart G.V., and Lotocki R.J. Prognostic significance of positive peritoneal cytology in endometrial carcinoma. Am. J. Obstet. Gynecol. 158 (1988) 303-306
15. Sutton G.P. Peritoneal cytology in endometrial carcinoma. Cancer Treat. Res. 49 (1989) 41-52
16. Turner D.A., Gershenson D.M., Atkinson N., Sneige N., and Wharton A.T. The prognostic significance of peritoneal cytology for stage I endometrial cancer. Obstet. Gynecol. 74 (1989) 775-780
17. Yazigi R., Piver M.S., and Blumenson L. Malignant peritoneal cytology as prognostic indicator in stage I endometrial cancer. Obstet. Gynecol. 62 (1983) 359-362
18. Milosevic MF., Dembo AJ., and Thomas GM. The clinical significance of malignant peritoneal cytology in stage I endometrial carcinoma. Int. J. Gynecol. Cancer. 2 5 (1992) 225-235
19. McLellan R., Dillon MB., Currie JL., and Rosenshein NB. Peritoneal cytology in endometrial cancer: a review. Obstet Gynecol Surv 44 10 (1989) 711-719
20. Taskiran C., Yuce K., Geyik P.O., Kucukali T., and Ayhan A. Predictability of retroperitoneal lymph node metastasis by using clinicopathologic variables in surgically staged endometrial cancer. Int. J. Gynecol. Cancer. 16 (2006) 1342-1347
21. Creasman W.T., Morrow C.P., Bundy B.N., Homesley H.D., Graham J.E., and Heller P.B. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer 60 (1987) 2035-2041
22. Fujiwara H., Saga Y., Takahashi K., Ohwada M., Enomoto A., Konno R., et al. Omental metastases in clinical stage I endometrioid adenocarcinoma. Int. J. Gynecol. Cancer 18 (2008) 165-167
23. Saga Y., Imai M., Jobo T., Kuramoto H., Takahashi K., Konno R., et al. Is peritoneal cytology a prognostic factor of endometrial cancer confined to the uterus?. Gynecol. Oncol. 103 (2006) 277-280
24. Obermair A., Geramou M., Tripcony L., Nicklin J.L., Perrin L., and Crandon A.J. Peritoneal cytology: impact on disease-free survival in clinical stage I endometrioid adenocarcinoma of the uterus. Cancer Lett. 164 (2001) 105-110
25. Kadar N., Homesley H.D., and Malfetano J.H. Positive peritoneal cytology is an adverse factor in endometrial carcinoma only if there is other evidence of extrauterine disease. Gynecol. Oncol. 46 (1992) 145-149
26. Gu M., Shi W., Barakat R.R., Thaler H.T., and Saigo P.E. Peritoneal washings in endometrial carcinoma. A study of 298 patients with histopathologic correlation. Acta Cytol. 44 (2000) 783-789
27. Takeshima N., Nishida H., Tabata T., Hirai Y., and Hasumi K. Positive peritoneal cytology in endometrial cancer: enhancement of other prognostic indicators. Gynecol. Oncol. 82 (2001) 470-473
28. Fadare O., Mariappan M.R., Hileeto D., Wang S., McAlpine J.N., and Rimm D.L. Upstaging based solely on positive peritoneal washing does not affect outcome in endometrial cancer. Mod. Pathol. 18 (2005) 673-680
29. Havrilesky L.J., Cragun J.M., Calingaert B., Alvarez Secord A., Valea F.A., Clarke-Pearson D.L., et al. The prognostic significance of positive peritoneal cytology and adnexal/serosal metastasis in stage IIIA endometrial cancer. Gynecol. Oncol. 104 (2007) 401-405
30. Obermair A., Geramou M., Gucer F., Denison U., Graf A.H., Kapshammer E., et al. Impact of hysteroscopy on disease-free survival in clinically stage I endometrial cancer patients. Int. J. Gynecol. Cancer 10 (2000) 275-279
31. Obermair A., Geramou M., Gucer F., Denison U., Graf A.H., Kapshammer E., et al. Does hysteroscopy facilitate tumor cell dissemination? Incidence of peritoneal cytology from patients with early stage endometrial carcinoma following dilatation and curettage (D and C) versus hysteroscopy and D and C. Cancer 88 (2000) 139-143
32. Kasamatsu T., Onda T., Katsumata N., Sawada M., Yamada T., Tsunematsu R., et al. Prognostic significance of positive peritoneal cytology in endometrial carcinoma confined to the uterus. Br. J. Cancer 88 (2003) 245-250
33. Tebeu P.M., Popowski G.Y., Verkooijen H.M., Casals J., Ludicke F., Zeciri G., et al. Impact of peritoneal cytology on survival of endometrial cancer patients treated with surgery and radiotherapy. Br. J. Cancer 89 (2003) 2023-2026
34. Tebeu P.M., Popowski Y., Verkooijen H.M., Bouchardy C., Ludicke F., Usel M., et al. Positive peritoneal cytology in early-stage endometrial cancer does not influence prognosis. Br. J. Cancer 91 (2004) 720-724
35. Havrilesky L.J., Secord AA., O'Malley DM., Bae-Jump V., Broadwater G., Tatagari N., Gehrig P.A., et al. Multicenter analysis of recurrence and survival in stage IIIA endometrial cancer. Gynecol. Oncol. 112 (2009) S81
36. Mariani A., Webb M.J., Keeney G.L., Aletti G., and Podratz K.C. Assessment of prognostic factors in stage IIIA endometrial cancer. Gynecol. Oncol. 86 (2002) 38-44
37. Slomovitz B.M., Ramondetta L.M., Lee C.M., Oh J.C., Eifel P.J., Jhingran A., et al. Heterogeneity of stage IIIA endometrial carcinomas: implications for adjuvant therapy. Int. J. Gynecol. Cancer 15 (2005) 510-516
38. Mariani A., Webb M.J., Keeney G.L., Aletti G., and Podratz K.C. Endometrial cancer: predictors of peritoneal failure. Gynecol. Oncol. 89 (2003) 236-242
39. Santala M., Talvensaari-Mattila A., and Kauppila A. Peritoneal cytology and preoperative serum CA 125 level are important prognostic indicators of overall survival in advanced endometrial cancer. Anticancer Res. 23 (2003) 3097-3103
40. Connell P.P., Rotmensch J., Waggoner S., and Mundt A.J. The significance of adnexal involvement in endometrial carcinoma. Gynecol. Oncol. 74 (1999) 74-79
41. Ayhan A., Taskiran C., Celik C., Aksu T., and Yuce K. Surgical stage III endometrial cancer: analysis of treatment outcomes, prognostic factors and failure patterns. Eur. J. Gynaecol. Oncol. 23 (2002) 553-556
42. Gemer O., Bergman M., and Segal S. Ovarian metastasis in women with clinical stage I endometrial carcinoma. Acta Obstet. Gynecol. Scand 83 (2004) 208-210
43. Randall M.E., Spirtos N.M., and Dvoretsky P. Whole abdominal radiotherapy versus combination chemotherapy with doxorubicin and cisplatin in advanced endometrial carcinoma (phase III): Gynecologic Oncology Group Study No. 122. J. Natl. Cancer Inst. Monogr. (1995) 13-15
44. Lee C.M., Slomovitz B.M., Greer M., Sharma S., Gregurich M.A., Burke T., et al. Practice patterns of SGO members for stage IIIA endometrial cancer. Gynecol. Oncol. 98 (2005) 77-83
45. Petru E., Luck H.J., Stuart G., Gaffney D., Millan D., and Vergote I. Gynecologic Cancer Intergroup (GCIG) proposals for changes of the current FIGO staging system. Eur. J. Obstet. Gynecol. Reprod. Biol. 143 (2009) 69-74
46. Lim S., Kim H.S., Lee K.B., Yoo C.W., Park S.Y., and Seo S.S. Does the use of a uterine manipulator with an intrauterine balloon in total laparoscopic hysterectomy facilitate tumor cell spillage into the peritoneal cavity in patients with endometrial cancer?. Int. J. Gynecol. Cancer 18 (2008) 1145-1149
47. Ben-Arie A., Tamir S., Dubnik S., Gemer O., Ben Shushan A., Dgani R., et al. Does hysteroscopy affect prognosis in apparent early-stage endometrial cancer?. Int. J. Gynecol. Cancer 18 (2008) 813-819
48. Revel A., Tsafrir A., Anteby S.O., and Shushan A. Does hysteroscopy produce intraperitoneal spread of endometrial cancer cells?. Obstet. Gynecol. Surv. 59 (2004) 280-284
49. Takac I., and Zegura B. Office hysteroscopy and the risk of microscopic extrauterine spread in endometrial cancer. Gynecol. Oncol. 107 (2007) 94-98
50. Vergote I., De Brabanter J., Fyles A., Bertelsen K., Einhorn N., Sevelda P., et al. Prognostic importance of degree of differentiation and cyst rupture in stage I invasive epithelial ovarian carcinoma. Lancet 357 (2001) 176-182
51. Yanoh K., Takeshima N., Hirai Y., Minami A., Tsuzuku M., Toyoda N., et al. Morphologic analyses of positive peritoneal cytology in endometrial carcinoma. Acta Cytol. 43 (1999) 814-819
52. Szpak C.A., Creasman W.T., Vollmer R.T., and Johnston W.W. Prognostic value of cytologic examination of peritoneal washings in patients with endometrial carcinoma. Acta Cytol. 25 (1981) 640-646
53. Hogberg T.R.P., Kristensen G., et al. A randomized phase-III study on adjuvant treatment with radiation (RT) ± chemotherapy (CT) in early-stage high-risk endometrial cancer (NSGO-EC-9501/EORTC 55991). J. Clin. Oncol. 25 (2007) Abstract 5503
54. Pecorelli A. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 2009;105(2):103-4.
55. Bansal S, Buck AM, Herzog TJ, Deutsch I, Burke WM, Wright JD. Stage IIIA Endometrial Carcinoma: outcome and Predictors of Survival. Obstet Gynecol 2009;114(1):100-5.