RHCE alleles detected after weak and/or discrepant results in automated Rh blood grouping of blood donors in northern Germany

Transfusion

Volumn 49, Issue 9, 2009, Pages 1803-1811

  Döscher, Andrea ^a   Vogt, Claudia ^a   Bittner, Rita ^a   Gerdes, Ingrid ^a   Petershofen, Eduard K ^a   Wagner, Franz F ^a  

^a DRK Blutspendedienst NSTOB   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; AUTOMATION; BLOOD DONOR; BLOOD GROUP RH; CONTROLLED STUDY; DNA DETERMINATION; DNA FINGERPRINTING; DNA POLYMORPHISM; EXON; GENE CONVERSION; GENE DELETION; GENE SEQUENCE; GERMANY; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RHCE GENE; SINGLE STRAND CONFORMATION POLYMORPHISM;

ALLELES; BLOOD DONORS; BLOOD GROUPING AND CROSSMATCHING; GERMANY; HUMANS; MUTATION; POLYMERASE CHAIN REACTION; RH-HR BLOOD-GROUP SYSTEM;

EID: 69249174057     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2009.02221.x     Document Type: Article

References (41)

1. Wagner FF. RhesusBase [database on the internet] cited 2008 Dec 5]. Available from: http://www.uni-ulm.de/∼fwagner/RH/RB
2. Blood group antigen mutation database [monograph on the internet] cited 2008 May 1]. Available from: http://www.ncbi.nlm.nih.gov/projects/gv/rbc/xslcgi. fcgi?cmd=bgmut/systems-info&system=rh
3. Noizat-Pirenne F, Lee K, Pennec PY, Simon P, Kazup P, Bachir D, Rouzaud AM, Roussel M, Juszczak G, Ménanteau C, Rouger P, Kotb R, Cartron JP, Ansart-Pirenne H. Rare RHCE phenotypes in black individuals of Afro-Caribbean origin: identification and transfusion safety. Blood 2002 100 : 4223 31.
4. Noizat-Pirenne F, Mouro I, Le Pennec PY, Ansart-Pirenne H, Juszczak G, Patereau C, Verdier M, Babinet J, Roussel M, Rouger P, Cartron JP. Two new alleles of the RHCE gene in Black individuals: the RHce allele ceMO and the RHcE allele cEMI. Br J Haematol 2001 113 : 672 9.
5. Kashiwase K, Ishikawa Y, Hyodo H, Watanabe Y, Ogawa A, Tsuneyama H, Toyoda C, Uchikawa M, Akaza T, Omine M, Juji T. E variants found in Japanese and c antigenicity alteration without substitution in the second extracellular loop. Transfusion 2001 41 : 1408 12.
6. Noizat-Pirenne F, Tournamille C, Gallon P, Juszczak G, Rouger P, Ansart-Pirenne H. ceRA: an RH allele variant producing a new rare blood. Transfusion 2006 46 : 1232 6.
7. Flegel WA, Wagner FF, Chen Q, Schlanser G, Frame T, Westhoff CM, Moulds MK. The RHCE allele ceCF: the molecular basis of Crawford (RH43). Transfusion 2006 46 : 1334 42.
8. Strobel E, Noizat-Pirenne F, Hofmann S, Cartron JP, Bauer MF. The molecular basis of the Rhesus antigen Ew. Transfusion 2004 44 : 407 9.
9. Noizat-Pirenne F, Le Pennec PY, Mouro I, Rouzaud AM, Juszczak G, Roussel M, Lauroua P, Krause C, Rouger P, Cartron JP, Ansart-Pirenne H. Molecular background of D(C)(e) haplotypes within the white population. Transfusion 2002 42 : 627 33.
10. Noizat-Pirenne F, Mouro I, Gane P, Okubo Y, Hori Y, Rouger P, Le Pennec PY, Cartron JP. Heterogeneity of blood group RhE variants revealed by serological analysis and molecular alteration of the RHCE gene and transcript. Br J Haematol 1998 103 : 429 36.
11. Wagner F, Frohmajer A, Ladewig B, Eicher NI, Lonicer CB, Müller TH, Siegel MH, Flegel WA. Weak D alleles express distinct phenotypes. Blood 2000 95 : 2699 708.
12. Gassner C, Schmarda A, Kilga-Nogler S, Jenny-Feldkircher B, Rainer E, Müller TH, Wagner FF, Flegel WA, Schönitzer D. RHD/CE typing by polymerase chain reaction using sequence-specific primers. Transfusion 1997 37 : 1020 6.
13. Faas BH, Ligthart PC, Lomas-Francis C, Overbeeke MA, von dem Borne AE, van der Schoot CE. Involvement of Gly96 in the formation of the Rh 26 epitope. Transfusion 1997 37 : 1123 30.
14. Wagner FF, Ladewig B, Flegel WA. The RHCE allele ceRT: D epitope 6 expression does not require D-specific amino acids. Transfusion 2003 43 : 1248 54.
15. Sachs L. Angewandte statistik. 5th ed. Berlin : Springer 1985.
16. Stattrek hypergeometric calculator [part of homepage on the internet]. Available from: http://stattrek.com/Tables/Hypergeometric.aspx
17. Westhoff CM, Silberstein LE, Wylie DE, Skavdahl M, Reid ME. 16Cys encoded by the RHce gene is associated with altered expression of the e antigen and is frequent in the R0 haplotype. Br J Haematol 2001 113 : 666 71.
18. Mouro I, Colin Y, Sistonen P, Le Pennec PY, Cartron JP, Le Van Kim C. Molecular basis of the RhCW (Rh8) and RhCX (Rh9) blood group specificities. Blood 1995 86 : 1196 201.
19. Coghlan G, Moulds M, Nylen E, Zelinski T. Molecular basis of the LOCR (Rh55) antigen. Transfusion 2006 46 : 1689 92.
20. Scharberg EA, Green C, Daniels G, Richter E, Klüter H, Bugert P. Molecular basis of the JAHK (RH53) antigen. Transfusion 2005 45 : 1314 8.
21. Noizat-Pirenne F, Mouro I, Le Pennec P, Verdier M, Babinet J, Jusczak G, Rouger P, Cartron J. Molecular basis of category EIV variant phenotype abstract Transfusion 1999 39 Suppl : 103S.
22. Rouillac C, Gane P, Cartron J, Le Pennec PY, Cartron JP, Colin Y. Molecular basis of the altered antigenic expression of RhD in weak D(Du) and RhC/e in RN phenotypes. Blood 1996 87 : 4853 61.
23. 0Har RH:33 phenotype results from substitution of exon 5 of the RHCE gene by the corresponding exon of the RHD gene. Br J Haematol 1996 92 : 751 7.
24. Bugert P, Scharberg EA, Geisen C, von Zabern I, Flegel WA. RhCE protein variants in South-western Germany detected by serological routine testing. Transfusion DOI: 10.1111/j.1537-2995.2009.02220.x.
25. Issitt PD. Applied blood group serology. 3rd ed. Miami (FL) : Miami Montgomery Ltd 1985.
26. Yan L, Wu J, Fu Q. Entrez nucleotide database [database on the internet]. Accession number DQ088169.
27. von Zabern I, Geisen C, Flegel WA. Entrez Nucleotide database [database on the internet]. First observation of the weak D type 54 allele, RHD(S122L), in a weak D phenotype encoded by 365C>T associated with a cDE haplotype; probable ethnic origin: Turkish. Accession number AM396583. [cited 2006 Aug 24]. Available from: http://www.ncbi.nlm.nih.gov/entrez/
28. Döscher A. Entrez nucleotide database [database on the internet]. Accession number AJ867386. [cited 2004 Dec 3]. Available from: http://www.ncbi.nlm.nih.gov/entrez/
29. Wagner F, Gassner C, Müller TH, Schönitzer D, Schunter F, Flegel WA. Molecular basis of weak D phenotypes. Blood 1999 93 : 385 93.
30. Döscher A. Entrez nucleotide database [database on the internet]. Accession number AJ784309. [cited 2004 Jul 19]. Available from: http://www.ncbi.nlm.nih.gov/entrez/
31. Wagner FF, Flegel WA, Weak D. Entrez nucleotide database [database on the internet]. Type 27, another RHD allele associated with weak D phenotype and caused by a P221S mutation. Accession number AJ504792. [cited 2002 Aug 2]. Available from: http://www.ncbi.nlm.nih.gov/entrez/
32. Döscher A. Entrez nucleotide database [database on the internet]. Accession number AM403488. [cited 2006 Sep 26]. Available from: http://www.ncbi.nlm.nih.gov/entrez/
33. Wagner FF, Ladewig B, Angert KS, Heymann GA, Eicher NI, Flegel WA. The DAU allele cluster of the RHD gene. Blood 2002 100 : 306 11.
34. Polin H, Danzer M, Hofer K, Gassner W, Gabriel C. Effective molecular RHD typing strategy for blood donations. Transfusion 2007 47 : 1350 5.
35. Yu X, Wagner FF, Witter B, Flegel WA. Outliers in RhD membrane integration are explained by variant RH haplotypes. Transfusion 2006 46 : 1343 51.
36. Wagner F, Kasulke D, Kerowgan M, Flegel WA. Frequencies of the blood groups ABO, Rhesus, D category VI, Kell, and of clinically relevant high-frequency antigens in south-western Germany. Infusionsther Transfusionsmed 1995 22 : 285 90.
37. Westhoff CM, Silberstein LE, Wylie DE. Evidence supporting the requirement for two proline residues for expression of c. Transfusion 2000 40 : 321 4.
38. Gassner C, Doescher A, Drnovsek TD, Rozman P, Eicher NI, Legler TJ, Lukin S, Garritsen H, Kleinrath T, Egger B, Ehling R, Körmöczi GF, Kilga-Nogler S, Schoenitzer D, Petershofen EK. Presence of RHD in serologically D-, C/E+ individuals: a European multicenter study. Transfusion 2005 45 : 527 38.
39. Chen YX, Peng J, Novaretti M, Reid ME, Huang CH. Deletion of arginine codon 229 in the Rhce gene alters e and f but not c antigen expression. Transfusion 2004 44 : 391 8.
40. Flegel WA, Eicher NI, Doescher A, Hustinx H, Gowland P, Mansouri Taleghani B, Petershofen EK, Bauerfeind U, Ernst M, von Zabern I, Schrezenmeier H, Wagner FF. In-frame triplet deletions in RHD alter the D antigen phenotype. Transfusion 2006 46 : 2156 61.
41. Ong J, Walker PS, Schmulbach E, Storry JR, Vege S, Westhoff C, Lomas-Francis C, Reid ME. Alloanti-c in a c-positive, JAL-positive patient. Vox Sang 2008 Dec 4. [Epub ahead of print T, Petershofen EK, Doescher A, Bauerfeind U, Müller TH, Schunter F. RHCE-D-CE hybrid genes can cause false-negative DNA typing of the Rh e antigen. Vox Sang 2002 83 : 268 72.