Intermittent preventive treatment of malaria in infants: How does it work and where will it work?

Tropical Medicine and International Health

Volumn 14, Issue 9, 2009, Pages 1003-1010

  Gosling, R D ^a,b   Carneiro, I ^a   Chandramohan, D ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b NORTH MIDDLESEX UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Anaemia; IPTi; Malaria; Public health impact; Review

Indexed keywords

AMODIAQUINE; CHLORPROGUANIL PLUS DAPSONE; FANSIDAR; MEFLOQUINE;

ANEMIA; DISEASE TRANSMISSION; DRUG; GEOGRAPHICAL VARIATION; HEALTH IMPACT; HETEROGENEITY; IMMUNE SYSTEM; MALARIA;

ANEMIA; CLINICAL TRIAL; COMMUNICABLE DISEASE; DISEASE TRANSMISSION; DRUG EFFECT; DRUG EFFICACY; HUMAN; IMMUNITY; INFECTION CONTROL; INFECTION PREVENTION; MALARIA; MORTALITY; PLASMODIUM FALCIPARUM; PREVENTION AND CONTROL; REVIEW; SINGLE DRUG DOSE;

ANEMIA; ANTIMALARIALS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INFANT; MALARIA; MALE; MODELS, THEORETICAL; PREVENTIVE HEALTH SERVICES;

EID: 69249166586     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2009.02303.x     Document Type: Review

References (39)

1. Cairns M, Carneiro I, Milligan P et al. (2008) Duration of protection against malaria and anaemia provided by intermittent preventive treatment in infants in Navrongo, Ghana. PLoS ONE 3, e2227.
2. Chandramohan D, Owusu-Agyei S, Carneiro I et al. (2005) Cluster randomised trial of intermittent preventive treatment for malaria in infants in area of high, seasonal transmission in Ghana. BMJ 331, 727 733.
3. Chandramohan D, Webster J, Smith L et al. (2007) Is the Expanded Programme on Immunisation the most appropriate delivery system for intermittent preventive treatment of malaria in West Africa? Tropical Medicine and International Health 12, 743 750.
4. Cisse B, Sokhna C, Boulanger D et al. (2006) Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial. Lancet 367, 659 667.
5. Clarke SE, Jukes MC, Njagi JK et al. (2008) Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial. Lancet 372, 127 138.
6. Cutts FT, Zaman SM, Enwere G et al. (2005) Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trial. Lancet 365, 1139 1146. (Pubitemid 40417563)
7. Dicko A, Sagara I, Sissoko MS et al. (2008) Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in Mali. Malaria Journal 7, 123.
8. Gesase S, Gosling RD, Hashim R et al. (2009) High resistance of Plasmodium falciparum to sulphadoxine\pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581. PLoS ONE 4, e4569.
9. Ghani AC, Sutherland CJ, Riley EM et al. (2009) Loss of population levels of immunity to malaria as a result of exposure-reducing interventions: consequences for interpretation of disease trends. PLoS ONE 4, e4383.
10. Gosling RD, Drakeley CJ, Mwita A Chandramohan D (2008a) Presumptive treatment of fever cases as malaria: help or hindrance for malaria control? Malaria Journal 7, 132.
11. Gosling RD, Ghani AC, Deen JL et al. (2008b) Can changes in malaria transmission intensity explain prolonged protection and contribute to high protective efficacy of intermittent preventive treatment for malaria in infants? Malaria Journal 7, 54.
12. Gosling RD, Gesase S, Mosha JF et al. (2009) Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, placebo-controlled trial. Lancet in press.
13. Greenwood B (2007) Intermittent preventive antimalarial treatment in infants. Clinical Infectious Diseases, 45, 26 28.
14. Greenwood B, Marsh K Snow R (1991) Why do some African children develop severe malaria? Parasitol Today 7, 277 281.
15. Grobusch MP, Lell B Schwarz NG (2007) Intermittent preventive treatment against malaria in infants in Gabon - a randomized, double-blind, placebo-controlled trial. Journal of Infectious Diseases 196, 1595 1602.
16. Guerra CA, Gikandi PW, Tatem AJ et al. (2008) The limits and intensity of Plasmodium falciparum transmission: implications for malaria control and elimination worldwide. PLoS Medicine 5, e38.
17. Institute of Medicine (2008) Assessment of the Role of Intermittent Preventive Treatment for Malaria in Infants. The National Academic Press, Washington, DC.
18. Kobbe R, Kreuzberg C, Adjei S et al. (2007) A randomized controlled trial of extended intermittent preventive antimalarial treatment in infants. Clinical Infectious Diseases 45, 16 25.
19. Lengeler C (2004) Insecticide-treated bed nets and curtains for preventing malaria. Cochrane Database Systemic Review, 2, CD000363.
20. Macete E, Aide P, Aponte JJ et al. (2006) Intermittent preventive treatment for malaria control administered at the time of routine vaccinations in Mozambican infants: a randomized, placebo-controlled trial. Journal of Infectious Diseases 194, 276 285.
21. MARA (2004) Mapping malaria risk in Africa: Malaria Distribution Model, MARA. http://www.mara.org.za/mapsinfo.htm (accessed on 11 June 2009).
22. Marks F, Meyer CG, Sievertsen J et al. (2004) Genotyping of Plasmodium falciparum pyrimethamine resistance by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry. Antimicrobial Agents and Chemotherapy 48, 466 472.
23. Massaga JJ, Kitua AY, Lemnge MM et al. (2003) Effect of intermittent treatment with amodiaquine on anaemia and malarial fevers in infants in Tanzania: a randomised placebo-controlled trial. Lancet, 361, 1853 1860.
24. May J, Adjei S, Busch W et al. (2008) Therapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants (IPTi) from Ghana and Gabon. Malar J 7, 198.
25. Mayor A, Serra-Casas E, Sanz S et al. (2008) Molecular markers of resistance to sulfadoxine-pyrimethamine during intermittent preventive treatment for malaria in Mozambican infants. Journal of Infectious Diseases 197, 1737 1742.
26. Mockenhaupt FP, Reither K, Zanger P et al. (2007) Intermittent preventive treatment in infants as a means of malaria control: a randomized, double-blind, placebo-controlled trial in northern Ghana. Antimicrobial Agents and Chemotherapy 51, 3273 3281.
27. Mwangi TW, Fegan G, Williams TN, Kinyanjui SM, Snow RW Marsh K (2008) Evidence for over-dispersion in the distribution of clinical malaria episodes in children. PLoS ONE 3, e2196.
28. Quelhas D, Puyol L, Quinto L et al. (2008) Impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on antibody responses to erythrocytic-stage Plasmodium falciparum antigens in infants in Mozambique. Clinical Vaccine Immunology 15, 1282 1291.
29. Ross A, Penny M, Maire N et al. (2008) Modelling the epidemiological impact of intermittent preventive treatment against malaria in infants. PLoS ONE 3, e2661.
30. Schellenberg D, Menendez C, Kahigwa E et al. (2001) Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzanian infants: a randomised, placebo-controlled trial. Lancet, 357, 1471 1477.
31. Schellenberg D, Menendez C, Aponte J et al. (2004) The changing epidemiology of malaria in Ifakara Town, southern Tanzania. Tropical Medicine and International Health 9, 68 76.
32. Schellenberg D, Menendez C, Aponte JJ et al. (2005) Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial. Lancet, 365, 1481 1483.
33. Schreiber N, Kobbe R, Adjei S et al. (2007) Immune responses after single-dose sulphadoxine-pyrimethamine indicate underestimation of protective efficacy of intermittent preventive treatment in infants. Tropical Medicine and International Health 12, 1157 1163.
34. Schwarz NG, Adegnika AA, Breitling LP et al. (2008) Placental malaria increases malaria risk in the first 30 months of life. Clinical Infectious Diseases 47, 1017 1025.
35. Sokhna C, Cisse B, Ba EL H et al. (2008) A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children. PLoS ONE 3, e1471.
36. Sutherland CJ, Drakeley CJ Schellenberg D (2007) How is childhood development of immunity to Plasmodium falciparum enhanced by certain antimalarial interventions? Malaria Journal 6, 161.
37. Tanzania Commission For Aids & Zanzibar Aids Commission, National Bureau Of Statistics & Measures (2008) Tanzania HIV\AIDS and Malaria Indicator Survey 2007-8: Preliminary Report. Ministry of Health, Dar Es Salaam.
38. White NJ (2005) Intermittent presumptive treatment for malaria. PLoS Medicine 2, e3.
39. WHO (2008) World Malaria Report: Tanzania Country profile. WHO, Geneva.