2,2′-Dihydroxychalcone, a glutathione transferase inhibitor, sensitises human colon adenocarcinoma cells to chlorambucil and melphalan, but not to actinomycin D

Molecular Medicine Reports

Volumn 1, Issue 4, 2008, Pages 575-579

  Goh, Kenneth ^a   Chen, Yufan ^a   Zheng, Lin ^a   Ong, Laichun ^a   Jin, Yi ^a   Chow, Pierce ^a   Zhang, Kai ^a  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

2,2 dihydroxychalcone; Actinomycin D; Chlorambucil; Glutathione conjugate export pump; Glutathione S transferase; Human colon adenocarcinoma cells; Melphalan

Indexed keywords

2,2' DIHYDROXYCHALCONE; CHALCONE DERIVATIVE; CHLORAMBUCIL; DACTINOMYCIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MELPHALAN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CHEMOSENSITIZATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG DETOXIFICATION; DRUG EFFECT; DRUG RESISTANCE; ENZYME ACTIVITY; ENZYME INHIBITION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; IC 50; PROTEIN DETERMINATION;

EID: 69249137096     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.1.4.575     Document Type: Article

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