Novel chemometric strategy based on the application of artificial neural networks to crossed mixture design for the improvement of recombinant protein production in continuous culture

Analytica Chimica Acta

Volumn 650, Issue 2, 2009, Pages 167-174

  Didier, Caroline ^a,c   Forno, Guillermina ^a,d   Etcheverrigaray, Marina ^a,c   Kratje, Ricardo ^a,c   Goicoechea, Héctor ^b,c  

^a Laboratorio de Cultivos Celulares   (Argentina)

^b Laboratorio de Cultivos Celulares   (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^d Zelltek SA ^*  (Argentina)

Author keywords

Artificial neural networks; Crossed mixture experimental design; Culture medium formulation

Indexed keywords

ARTIFICIAL NEURAL NETWORK; ARTIFICIAL NEURAL NETWORKS; CHEMOMETRICES; CHO CELL; CONTINUOUS CULTURE; CROSSED MIXTURE EXPERIMENTAL DESIGN; CULTURE MEDIA; CULTURE MEDIUM FORMULATION; EMPIRICAL DATA; EXPERIMENTAL DESIGN; MAMMALIAN CELLS; MIXTURE DESIGN; MULTIRESPONSE; PRODUCTION PROCESS; REAL-LIFE SYSTEMS; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN PRODUCTIONS; SPECIFIC GROWTH RATE;

ANIMAL CELL CULTURE; BACKPROPAGATION; CELL CULTURE; DESIGN OF EXPERIMENTS; GENETIC ENGINEERING; MAMMALS; MIXTURES; PRODUCTION ENGINEERING; PROTEINS; STATISTICS;

NEURAL NETWORKS;

RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; ARTIFICIAL NEURAL NETWORK; BIOTECHNOLOGICAL PRODUCTION; CHEMOMETRIC ANALYSIS; CHO CELL; CONTINUOUS CULTURE; CONTINUOUS STIRRED TANK REACTOR; CONTROLLED STUDY; CULTURE MEDIUM; GROWTH RATE; NONHUMAN; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS OPTIMIZATION;

ALGORITHMS; ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; NEURAL NETWORKS (COMPUTER); RECOMBINANT PROTEINS;

MAMMALIA;

EID: 69249135420     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2009.07.051     Document Type: Article

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