Protective activity of the stem bark aqueous extract of Musanga cecropioides in carbon tetrachloride- and acetaminophen-induced acute hepatotoxicity in rats

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 6, Issue 2, 2009, Pages 131-138

  Adeneye, Adejuwon Adewale ^a  

^a LAGOS STATE UNIVERSITY   (Nigeria)

Author keywords

Acetaminophen; Carbon tetrachloride; Hepatoprotective activities; Musanga cecropioides; Wistar rats

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALOID; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; FLAVONOID; MUSANGA CECROPIOIDE EXTRACT; ORNITHINE CARBAMOYLTRANSFERASE; PARACETAMOL; PLANT EXTRACT; UNCLASSIFIED DRUG;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BARK; CONTROLLED STUDY; DRUG ISOLATION; HISTOPATHOLOGY; LIVER INJURY; LIVER PROTECTION; MALE; MEDICINAL PLANT; MUSANGA CECROPIOIDE; NONHUMAN; PLANT STEM; RAT; SOLVENT EXTRACTION; SOXHLET EXTRACTION; WISTAR RAT;

ACETAMINOPHEN; ALKALOIDS; ANIMALS; ANTIOXIDANTS; CARBON TETRACHLORIDE; CARBON TETRACHLORIDE POISONING; CARBOXYL AND CARBAMOYL TRANSFERASES; CECROPIACEAE; DRUG-INDUCED LIVER INJURY; FLAVONOIDS; LIVER; MALE; NIGERIA; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; PLANT STEMS; RATS; RATS, WISTAR; TRANSAMINASES;

EID: 69249120507     PISSN: 01896016     EISSN: 01896016     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Adeneye, A.A., Ajagbonna, O.P., Adeleke, T.I. and Bello, S.O. (2006a). Preliminary oral toxicity and phytochemical studies of the stem bark aqueous extract of Musanga cecropioides in rats. J. Ethnopharmacol., 105(3): 374-379.
2. Adeneye, A.A., Ajagbonna, O.P., Mojiminiyi, F.B.O., Odigie, I.P., Etarrh, R.R., Ojobor, P.D., Adeneye, A.K. (2006b). The hypotensive mechanisms for the aqueous extract of Musanga cecropioides stem bark in rats. J. Ethnopharmacol. 106(2): 203 - 207.
3. Adeneye, A.A., Ajagbonna, O.P., Ayodele O.W. (2007). The hypoglycemic and antidiabetic activities of the stem bark aqueous and alcohol extracts of Musanga cecropioides in normal and alloxan-induced diabetic rats. Fitoterapia 78(7-8): 502-505.
4. Adesunkanmi, A.R.K., Akinkuolie, A.A. and Badru, O.S. (2002). A five year analysis of death in accident and emergency room of a semi-urban Hospital. West Afr. J. Medicine 21(2): 99-104.
5. Blazka, M.E., Wilmer, J.L., Holladay, S.D., Wilson, R.E. and Luster, M.I. (1995). Role of proinflammatory cytokines in acetaminophen hepatotoxicty. Toxicol. Applied Pharmacol. 133: 43-52.
6. Blazka, M.E., Wilmer, J.L., Holladay, S.D., Wilson, R.E. and Luster, M.I. (1996). Histopathology of acetaminophen-induced liver changes: role of interleukin 1α and tumor necrosis factor α. Toxicol. Pathol. 24: 181-189.
7. Canadian Council of Animal Care (1984). Guide to the handling and use of experimental animals, vol. 2, Ottawa: Ontario., Canada.
8. Carini, R., Comoglio, A., Albano, E. and Poli, G. (1992). Lipid peroxidation and irreversible damage in the rat hepatocytes model: Protection by the silybin-phospholipid complex IdB 1016. Biochem. Pharmacol. 38: 2859-2865.
9. Comporti, M., Maellaro, E., De Bello, B. and Casini, A.F. (1991). Glutathione depletion: its effects on other antioxidants systems and hepatocellular damage. Xenobiotica 21: 1067-1076.
10. Erdelmeier, C.A.J. and Koch, E. (2006). Pharmacological Effects of a decolorised St. John's Wort Extract Designed for Topical Application. Planta Medica 72: 1064-1068.
11. Fraga, C., Martino, V., Ferraro, G., Coussio, J. and Boveris, A. (1987). Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminiscence. Biochem Pharmacol. 36: 717-720
12. Gill, L.S. (2006). Ethnomedical Uses of Plants in Nigeria. University of Benin Press, Benin City, Nigeria.
13. Ishida, Y., Kondo, T., Ohshima, T., Fujiwara, H., Iwakura, Y. and Mukaida, N. (2002). A pivotal involvement of IFN-γ in the pathogenesis of acetaminophen-induced acute liver injury. FASEB Journal 16: 1227-1236.
14. Kee, J.L. (2002). Laboratory tests: Alanine aminotransferase (ALT) (serum). In: Laboratory and diagnostic tests with nursing implications. Prince-Hall Publications, New Jersey, USA. pp. 16.
15. Laughton, M.J., Halliwell, B., Evans, P.J. and Hoult, J.R.S. (1989). Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myeicetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. Biochem. Pharmacol. 38: 2859-2865.
16. Lanhers, M.C., Joyeux, M., Soulimani, R., Fleurentin, J., Sayag, M., Mortier, F., Younos, C. and Pelt, J. (1991). Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile, Pneumus boldus. Planta Medica 57: 110-115
17. Letteron, P., Labbe, G., Degott, C., Berson, A., Fromenty, B., Delarforge, M., Larrey, D. and Pessayre, D. (1990). Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that Silymarin acts both as an inhibitor of metabolic activation and as a chain-breaker anti-oxidants. Bioch. Pharmacol. 39 (12): 2027-2934.
18. Luster, M.I., Simeonova, P.P., Galluci, R.M., Bruccoleri, A., Blazka, M.E. and Yucesoy, B. (2001). Role of inflammation in chemical-induced hepatotoxicity. Toxicol. Lett. 120: 317-321
19. Mitchell, J.R., Jollow, D., Potter, W.Z., Gillette, J.R. and Brodie, B.B. (1973). Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. Journal of Pharmacology and Exptl. Therapeutics 187: 211-217
20. Murayama, H., Ikemoto, M., Fukuda, Y., Tsunekana, S. and Nagata, A. (2007). Advantage of serum type-1 arginase and ornithine carbamoyltransferase in the evaluation of acute and chronic liver damage induced by thioacetanide in rats. Clinica Chimica Acta 375(1-2): 63-68.
21. Muriel, P., Garciapina, T., Perez-Alvarez, V. and Mourelle, M. (1992). Silymarin protects against paracetamol-induced liver peroxidation and liver damage. J. Applied Toxicol. 12: 439-442
22. Odetola, A.A. and Akojenu, S.M. (2000). Anti-diarrheal and gastrointestinal potentials of the aqueous extract of Phyllanthus amarus (Euphorbiaceae). Afr. J. Med. medical Sci. 29: 119-122.
23. Packer, J., Slater, T. and Wilson, R. (1978). Reactions of the carbon tetrachloride-related peroxy free radical with amino acids: Pulse radiolysis evidence. Life Sci. 23: 2617-2620.
24. Paya, M., Ferrandiz, M.L., Sanz, M.J. and Alcaraz, M.J. (1993). Effects of phenolic compounds on bromobenzene-mediated hepatotoxicity in mice. Xenobiotica 23: 327-233.
25. Recknagel, R.O. and Glende, E.A. Jnr. (1973). Carbon tetrachloride hepatotoxicity: an example of lethal cleavage. CRC Crit. Rev. Toxicol. 2: 263-297.
26. Sanz, M.J., Ferrandiz, M.L., Cejudo, M., Terencio, M.C., Gil, B., Bustos, G., Ubeda, A., Gunasegaran, R. and Alcaraz, M.J. (1994). Influence of a series of natural flavonoids on free radical generating systems and oxidative stress. Xenobiotica 24: 689-699.
27. Shah, H., Martman, S.P. and Weinhouse, S. (1979). Formation of carbonyl chloride in carbon tetrachloride metabolism by rat liver in vitro. Cancer Res. 39: 3942-3947.
28. Smith, G.S., Nadig, D.E., Kokoska, E.R., Solomon, H., Tiniakos, D.G. and Miller, T.A. (1998). Role of neutrophils in hepatotoxicity induced by oral acetaminophen administration in rats. J. Surgical Res. 80: 252-258.
29. Tegeris, A.S., Smalley Jnr., H.E., Earl, F.L. and Curtis, J.M. (1969). Ornithine carbamoyl transferase as a liver function test comparative studies in the dog, swine and man. Toxicol. Applied Pharmacol. 14(1): 54-66.
30. Tsai, C.C., Kao, C.T., Hsu, C.T., Lin, C.C. and Lin, J.G. (1997). Evaluation of four prescriptions of traditional Chinese medicine: Syh-Mo-Yiin, Guizhi-Fulin-Wan, Shieh Qing Wan and Syh-Nih-San on experimental acute liver damage in rats. J. Ethnopharmacol. 55: 213-222
31. United States NIH publication no. 85-23, revised in 1985.